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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Designing a mandibular advancement device with topology optimization for a partially edentulous patient | Statement of problem. Patients with partial tooth loss treated with implant-supported fixed partial dentures (FPDs) have difficulty using conventional mandibular advancement devices (MADs) because of the risk of side effects. Also, which design factors affect biomechanical stability when designing MADs with better stability is unclear. Purpose. The purpose of this finite element (FE) analysis study was to analyze the effect of the MAD design on biomechanical behavior and to propose a new design process for improving the stability of MADs. Material and methods. Each 3D model consisted of the maxillofacial bones, teeth, and implant-supported FPDs located in the left tooth loss area from the first premolar to the second molar and a MAD. Three types of custom-made MADs were considered: a complete-coverage MAD covering natural tooth-like conventional MADs, a shortened MAD excluding the coverage on the implant-supported FPD, and a newly designed MAD without anterior coverage. For the new MAD design, topology optimization was conducted to reduce the stress exerted on the teeth and to improve retention of the MAD. The new MAD design was finished by excluding the coverage of the maxillary and mandibular central incisors based on the results of the topology optimization. A mandibular posterior restorative force for a protrusion amount of 40% was used as the loading condition. The principal stress and pressure of the cancellous bone and periodontal ligaments (PDLs) were identified. Results. Considering the load concentration induced by the complete-coverage MAD, bone resorption risk and root resorption risk were observed at both ends of the mandibular teeth. The shortened MAD resulted in the highest stress concentration and pressure with the worst stability. However, in the case of the complete-coverage MAD, the pressure in the PDLs was reduced to the normal range, and the risk of root resorption was reduced. Conclusions. For patients with implant-supported FPDs, MAD designs with different extents of coverage had an influence on biomechanical behavior in terms of stress distribution in cancellous bone and PDLs. A MAD design without anterior coverage provided improved stability compared with complete-coverage or shortened designs. The presented method for MAD design, which combined FE analysis and topology optimization, could be effectively applied in the design of such improved MADs. | Park, Si-Myung; Park, Soyeon; Shin, Sangkyun; Lee, Hyeonjong; Ahn, Su-Jin; Kim, Laehyun; Lee, Soo-Hong; Noh, Gunwoo | Korea Inst Sci & Technol, Ctr Bion, Seoul, South Korea; Yonsei Univ, Sch Mech Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Mech Engn, 1370 Sankyuk Dong, Daegu 41566, South Korea; Pusan Natl Univ, Dept Prosthodont, Yangsan, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Sch Dent, Dept Biomat & Prosthodont, Seoul, South Korea | Lee, Jee-Yon/GER-4141-2022; Lee, Hyeonjong/HDM-6492-2022 | 57192916912; 59609350600; 37054653900; 57190951278; 55145967600; 59157677000; 56113249500; 55010264000 | gunwoo@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 123 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 3.426 | 26.6 | 1.37 | 2025-06-25 | 14 | 13 | OBSTRUCTIVE SLEEP-APNEA; FINITE-ELEMENT-ANALYSIS; ORAL APPLIANCE DESIGN; STRESS-DISTRIBUTION; PARTIAL DENTURE; MANAGEMENT; FRAMEWORK; PRESSURE; EFFICACY | Dental Implants; Dental Prosthesis, Implant-Supported; Denture, Partial, Fixed; Finite Element Analysis; Humans; Occlusal Splints; finite element analysis; fixed partial denture; human; implant-supported denture; occlusal splint; tooth implant | English | 2020 | 2020-06 | 10.1016/j.prosdent.2019.05.023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of scan body exposure and operator on the accuracy of image matching of implant impressions with scan bodies | Statement of problem. Accurate image matching of the scan with the design of the scan body is essential to replicate the actual implant position in the software program. In situations where the scan part of the scan body is partially embedded in the gingival tissue, the influence of the scan image deficiency on the accuracy of image matching has not been clarified. Purpose. The purpose of this in vitro study was to examine the effects of scan body exposure and different operators on the accuracy of image matching of the scan body. Material and methods. Six groups with different scan body exposures (fully exposed, 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, and 2.5 mm less exposed) were digitized, and the scan images were transferred to a CAD software program, where the design of the scan body was matched to the scan image of each group. Based on the position of the scan body design, a virtual implant was created. The image matching process was performed 7 times for each group by 2 operators (N=84). The linear and angular deviations of the virtual implants were analyzed 3-dimensionally. Two-way ANOVA, equivalence, and concordance correlation coefficient statistics were used to verify the effects of scan body exposure and operator on the image matching. Results. As the exposure of the scan body was reduced, the deviations in implant positioning were significantly increased (P<.001). The concordance correlation coefficient indicated strong agreement between the 2 operators. Conclusions. Reduced exposure of the scan body significantly influenced the accuracy of implant positioning in the software program. Operator differences may not affect the accuracy of scan body image matching. | Choi, Yong-Do; Lee, Kyeong Eun; Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Sch Dent, Dept Prosthodont, Daegu, South Korea | Mai, Hang-Nga/Q-9865-2018 | 57217787575; 56041259000; 56964780900; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 124 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 3.426 | 26.6 | 2.45 | 2025-06-25 | 29 | 29 | Computer-Aided Design; Dental Implants; Dental Impression Technique; computer aided design; dental impression; tooth implant | English | 2020 | 2020-09 | 10.1016/j.prosdent.2020.04.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effects of supporting conditions and anchor microscrew on the stabilization of the implant guide template during the drilling process: An in vitro study | Statement of problem. Implant placement errors have been reported in guided surgeries because of movement of the guide template during implant placement. With a completely limiting guide design with high restrictions, guide template stabilization is essential to minimize mobility during the drilling process. Purpose. The purpose of this in vitro study was to evaluate the effects of supporting conditions and the use of an anchor microscrew on the seating and functional stabilization of a computer-aided design and computer-aided manufacturing (CAD-CAM) implant surgical guide with a completely limiting design. Material and methods. Twelve implant surgical guide templates were fabricated under different supporting conditions: tooth-mucosa, tooth-tooth, tooth-screw, and screw-screw (n=3 per group). In the tooth-screw and screw-screw groups, anchor microscrews and anchor caps were used to fix the guide templates. The seating stability of the templates was evaluated by using a micromovement assessment. The functional stability of the templates was analyzed during the drilling process by using a motion tracking method. One-way analysis of variance and the Tukey HSD post hoc test were conducted to compare the differences among the groups (alpha=.05). Results. The tooth-tooth, tooth-screw, and screw-screw groups exhibited similar seating stability, which was significantly more stable than that of the tooth-mucosa group (P<.001). In terms of functional stability, the tooth-mucosa group reported the highest positional deviation and motion magnitude, whereas low values were found in the tooth-screw and screw-screw groups (P<.001). Conclusions. The use of anchor microscrews can increase the seating and functional stability of CAD-CAM guide templates during the drilling process for implant placement. | Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Sch Dent, Dept Prosthodont, 2175 Dalgubeoldae Ro, Daegu 41940, South Korea | Mai, Hang-Nga/Q-9865-2018 | 56964780900; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 124 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 3.426 | 26.6 | 0.82 | 2025-06-25 | 10 | 12 | SURGICAL GUIDES; ACCURACY; SURGERY; PLACEMENT; PRECISION | Bone Screws; Computer-Aided Design; Dental Implants; bone screw; computer aided design; tooth implant | English | 2020 | 2020-12 | 10.1016/j.prosdent.2020.06.033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prediction of learning curves of 2 dental CAD software programs, part 2: Differences in learning effects by type of dental personnel | Statement of problem. Dental computer-aided design (CAD) software programs are essential elements of the digital workflow. Therefore, it is necessary to study the learning effect of dental CAD software programs for efficient use. Purpose. The purpose of this in vitro study was to predict the learning curve of dental CAD software programs according to dental personnel by using the Wright model and to investigate the tendency of dental personnel to reduce working time according to repeated learning. Material and methods. A total of 36 participants were recruited, including an equal number of dentists, dental technicians, and dental students (12 each). A custom abutment design was evaluated by using exocad CAD and Deltanine CAD software programs. The design was carried out in the following order: 4 steps repeated 3 times each. This study applied the formula of the Wright model to predict 500 repetitive times. In the statistical analysis, 3-repetition and 500-repetition times were analyzed with the Kruskal-Wallis H test and Friedman test (alpha=.05), and a post hoc comparison was performed by using the Mann-Whitney U-test and Bonferroni correction method (alpha=.017). Results: Three repetitions resulted in shorter working time in the dental technician group. The 3-repetition time decreased statistically for all dental personnel (P<.001). The time for 500 repetitions showed a statistically significant difference according to the type of dental personnel (P=.036), but no significant difference was found after the fourth iteration (fifth iteration: P=.076). Furthermore, the estimated time of 500 iterations decreased statistically significantly from the first to the 500th iteration (P<.001). Conclusions: All dental personnel showed learning effects of dental CAD software programs. Although the dental technician group initially showed less working time, after initial learning, the same learning effect appeared, regardless of the type of dental personnel. | Son, KeunBaDa; Lee, Kyu-Bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019 | 57202916520; 15925571200 | kblee@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 123 | 5 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 3.426 | 26.6 | 1.64 | 2025-06-25 | 17 | 14 | UNIVARIATE; SERIES; COST | Computer-Aided Design; Dental Prosthesis Design; Dental Technicians; Humans; Learning Curve; Software; Workflow; computer aided design; dental technician; human; learning curve; prosthesis design; software; workflow | English | 2020 | 2020-05 | 10.1016/j.prosdent.2019.05.026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Reliability of digital measurement methods on the marginal fit of fixed prostheses: A systematic review and meta-analysis of in vitro studies | Statement of problem. Digital methods have been increasingly used to evaluate the fit of prostheses, but the accuracy of digital methodology has not been fully clarified. Purpose. The purpose of this systematic review and meta-analysis was to assess the reliability of digital measurement methods for evaluating the marginal fit of fixed dental prostheses (FDPs) and to identify the potential factors that can influence the accuracy of the measurement methods. Material and methods. The differences between digital and conventional measurement methods were analyzed by searching PubMed, Scopus, Web of Science, and Google Scholar databases for studies reporting the marginal fit of FDPs. The agreement of data collection among the reviewers was confirmed by the Cohen kappa coefficient, and the MINORS scale was used to rate the quality of the included studies. The heterogeneity among the studies was evaluated, and meta-analyses with global and subgroup analyses were performed. Results. Ten in vitro studies were selected according to the eligibility criteria with substantial interreader concordance (kappa=0.88). The standard mean difference of the meta-analysis for marginal discrepancy was 0.12 mu m (95% confidence interval: -0.12 to 0.35), indicating that no statistically significant differences were found in the marginal discrepancies observed with digital and conventional methods (P=.343). The subgroup analysis for alloy-based prostheses was not significantly different, nor between the material and measurement methods (P=.060). Conclusions. Digital methods appear to be reliable as an alternative to conventional methods for evaluating the marginal fit of FDPs. To confirm the results of this study and to identify the influencing factors on the accuracy of digital measurement methods, further controlled laboratory and clinical studies are needed. | Mai, Hai Yen; Lee, Won Kee; Kwon, Tae-Geon; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Dept Oral & Maxillofacial Surg, Sch Dent, Daegu, South Korea | 57217872800; 22953484700; 35205433300; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHETIC DENTISTRY | J PROSTHET DENT | 0022-3913 | 1097-6841 | 124 | 3 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 3.426 | 26.6 | 0.54 | 2025-06-25 | 14 | 13 | DENTAL PROSTHESES; SINGLE CROWNS; RESTORATIONS; ADAPTATION; VALIDATION; PRECISION; CAST; 2D; 3D | Computer-Aided Design; Dental Implants; Dental Marginal Adaptation; Dental Prosthesis Design; Reproducibility of Results; computer aided design; dental marginal adaptation; meta analysis; prosthesis design; reproducibility; tooth implant | English | 2020 | 2020-09 | 10.1016/j.prosdent.2020.04.011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Ultrasonic fatigue test at cryogenic temperatures on SUS304L by cold rolling ratio for LNG carriers | This study examined the effects of cold rolling ratio and cryogenic temperatures on the mechanical properties of a 1.5 mm SUS304L sheet, the original material used in membrane-type liquefied natural gas (LNG) storage tanks. The original sheet was cold rolled to reduce its thickness in order to examine the effect of cold rolling ratio. And to identify the effect of cryogenic temperatures, very high cycle fatigue (VHCF) characteristics were obtained at -162 degrees C, using the ultrasonic fatigue tester. The fatigue limit of a 1.5 mm specimen, measured at -162 degrees C in the ultrasonic fatigue test (UFT) was 252 MPa, while that of 1.3 mm and 1.1 mm cold rolled specimens was 503 MPa and 597 MPa, up by about 99.6% and 137% respectively. The fatigue limit of 1.3 mm and 1.1 mm cold rolled specimens measured at -196 degrees C was 550 MPa and 690 MPa, up by about 88.4% and 136.3% respectively. As such, the fatigue strength of the cold rolled specimen in the UFT tend to increase in a nearly linear manner, compared to that of the original material, as the cold rolling ratio and the effect of cryogenic temperatures. | Shim, Hyun-Bo; Nahm, Seung-Hoon; Cho, In-Sik; Suh, Chang-Min | Yeungnam Univ, Sch Mech Engn, Gyongsan, South Korea; Korea Res Inst Stand & Sci, Daejeon, South Korea; Mbrosia Co Ltd, Asan, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea | hbshim@ynu.ac.kr;shnahm@kriss.re.kr;mbrosia1018@naver.com;cmsuh@knu.ac.kr; | ENGINEERING FAILURE ANALYSIS | ENG FAIL ANAL | 1350-6307 | 1873-1961 | 112 | SCIE | ENGINEERING, MECHANICAL;MATERIALS SCIENCE, CHARACTERIZATION & TESTING | 2020 | 3.114 | 26.6 | 5 | Cryogenic temperatures; Ultrasonic fatigue test; LNG carriers; Cold rolling ratio; SUS304L | GROWTH-BEHAVIOR; STEEL; RESISTANCE; CRACKS | English | 2020 | 2020-05 | 10.1016/j.engfailanal.2020.104515 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Development and External Validation of Multiparametric MRI-Derived Nomogram to Predict Risk of Pathologic Upgrade in Patients on Active Surveillance for Prostate Cancer | OBJECTIVE. The aim of this study was to create, develop, and externally validate a nomogram that predicts pathologic upgrade in patients on active surveillance (AS) for prostate cancer using commonly available clinical and multiparametric MRI (mpMRI) factors. MATERIALS AND METHODS. A consecutive sample of 300 patients undergoing AS for prostate cancer at the Keirnyung University Dongsan Hospital between 2010 and 2016 was used to develop the nomogram. The validation cohort consisted of 150 patients undergoing active surveillance at Kyungpook National University Hospital between 2013 and 2017. The study outcome was the occurrence of pathologic upgrade in AS patients. The relationship between the clinical and mpMRI factors considered and pathologic upgrade was tested using univariate and multivariate logistic regression analyses. The predictive accuracy of the nomogram was determined using the ROC AUC. RESULTS. The overall rate of pathologic upgrade was 25.0% in the developmental cohort and 22.0% in the validation cohort. Significant variables in the models were age, prostate-specific antigen level, biopsy grade group 2, baseline Prostate Imaging Reporting and Data System (PI-RADS) scores of 4 and 5, positive cores on initial biopsy greater than 1, and biopsy cores with 50% or more tumor involvement. The progression seen on mpMRI of PI-RADS score was significantly associated with pathologic upgrade. The nomogram used to predict the risk of pathologic upgrade had a predictive accuracy of 0.78 in the external validation cohort. CONCLUSION. This study developed and externally validated a nomogram that predicts the risk of pathologic upgrade on the basis of commonly used factors. This nomogram may be used to assist management decision making for patients on AS for prostate cancer. | Kim, See Hyung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Sang-Hyun/J-5402-2012 | 57216511386 | kimseehyung72@outlook.kr; | AMERICAN JOURNAL OF ROENTGENOLOGY | AM J ROENTGENOL | 0361-803X | 1546-3141 | 214 | 4 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 3.959 | 26.7 | 0.17 | 2025-06-25 | 5 | 4 | active surveillance; multiparametric MRI; nomogram; pathologic upgrade; prostate cancer | IMAGING-TARGETED BIOPSY; MANAGEMENT; STATEMENT; SELECTION; MEN; AUA | Active surveillance; Multiparametric MRI; Nomogram; Pathologic upgrade; Prostate cancer | Aged; Aged, 80 and over; Humans; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging; Neoplasm Grading; Nomograms; Predictive Value of Tests; Prostatic Neoplasms; Risk Assessment; Watchful Waiting; prostate specific antigen; adult; age; aged; Article; cancer epidemiology; cancer risk; cohort analysis; diagnostic accuracy; diagnostic test accuracy study; human; major clinical study; male; multiparametric magnetic resonance imaging; nomogram; prediction; predictive value; priority journal; prostate cancer; risk assessment; tumor biopsy; validation study; cancer grading; middle aged; pathology; prostate tumor; very elderly; watchful waiting | English | 2020 | 2020-04 | 10.2214/ajr.19.22196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience | Indolamine-2,3-dioxygenase (IDO) is an intracellular enzyme that catalyzes amino acid tryptophan to L-kynurenine. IDO is overexpressed in various cancers and several IDO inhibitors have been assessed in multiple clinical trials. If an IDO inhibitor is to be commercialized, IDO immunohistochemistry will be an important method. In this study, 80% (28/35) of mature T- and natural killer (NK)-cell neoplasms showed positivity for IDO protein (score 1: five, score 2: one, score 3: seven, score 4: fifteen). In addition, 29.9% (23/77) of mature B-cell lymphomas showed positivity for IDO protein (score 1: three, score 2: tewelve, score 3: four, score 4: four). In mature B-cell lymphomas, 95.7% (22/23) of IDO positive cases were diffuse B-cell lymphomas. Our study includes various types of lymphoma that were previously unreported and shows various patterns of IDO stain according to the type. When the results are accumulated, IDO immunohistochemistry will be a useful tool to diagnose lymphomas and to predict their prognosis. | Kim, Mee-seon; Park, Tae In; Son, Shin-Ah; Lee, Hyoun Wook | Kyungpook Natl Univ Hosp, Dept Pathol, Dongdeok Ro 130, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Pathol, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Pathol, Sch Med, Chang Won 51353, South Korea | Lee, Hyoungjin/GRR-7154-2022 | 56123006700; 7401801814; 57197328338; 14826936300 | kimm2342@gmail.com;tipark@knu.ac.kr;sina2-2@daum.net;sudowo@naver.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 10 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 3.706 | 26.7 | 0.69 | 2025-06-25 | 8 | 7 | Indolamine-2; 3-dioxygenase (IDO); lymphoma; immunohistochemistry (IHC) | T-CELL; TRYPTOPHAN CATABOLISM; INHIBITION; CANCER; SERUM; PROLIFERATION; MECHANISMS; EXPRESSION | Immunohistochemistry (IHC); Indolamine-2,3-dioxygenase (IDO); Lymphoma | indoleamine 2,3 dioxygenase; adolescent; adult; aged; anaplastic large cell lymphoma; angioimmunoblastic t cell lymphoma; Article; B cell lymphoma; cancer prognosis; child; classical Hodgkin lymphoma; diffuse large B cell lymphoma; enteropathy associated T cell lymphoma; female; Hodgkin disease; human; human cell; human tissue; immunohistochemistry; lymphocyte; lymphocytic infiltration; lymphoma; lymphomatoid papulosis; major clinical study; male; middle aged; natural killer cell; NK T cell lymphoma; nodular lymphocyte predominant Hodgkin lymphoma; peripheral T cell lymphoma; retrospective study; school child; subcutaneous t cell lymphoma; T lymphocyte; very elderly; young adult | English | 2020 | 2020-05 | 10.3390/diagnostics10050275 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Recent Progress in Birdcage RF Coil Technology for MRI System | The radio frequency (RF) coil is one of the key components of the magnetic resonance imaging (MRI) system. It has a significant impact on the performance of the nuclear magnetic resonance (NMR) detection. Among numerous practical designs of RF coils for NMR imaging, the birdcage RF coil is the most popular choice from low field to ultra-high field MRI systems. In the transmission mode, it can establish a strong and homogeneous transverse magnetic field B1 for any element at its Larmor frequency. Similarly, in the reception mode, it exhibits extremely high sensitivity for the detection of even faint NMR signals from the volume of interest. Despite the sophisticated 3D structure of the birdcage coil, the developments in the design, analysis, and implementation technologies during the past decade have rendered the development of the birdcage coils quite reasonable. This article provides a detailed review of the recent progress in the birdcage RF coil technology for the MRI system. | Ahmad, Sheikh Faisal; Kim, Young Cheol; Choi, Ick Chang; Kim, Hyun Deok | Kyungpook Natl Univ, Inst Adv Convergence Technol, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Kim, Yong Joon/IQS-7291-2023 | 37074158500; 57218240460; 37074258500; 55663858300 | faisalthestar@knu.ac.kr;yckim@knu.ac.kr;choic@knu.ac.kr;hdkim@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 10 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 3.706 | 26.7 | 0.49 | 2025-06-25 | 29 | 28 | birdcage coil; RF coil; volume coil; numerical method; analytical solution; electromagnetic simulation; MRI; NMR imaging; design issues; dual resonance | MAGNETIC-RESONANCE; VOLUME COIL; ELECTROMAGNETIC-FIELDS; COMPUTATIONAL ANALYSIS; RADIOFREQUENCY COIL; MUTUAL INDUCTANCE; CAGE COIL; 4.7 T; DESIGN; FREQUENCY | Analytical solution; Birdcage coil; Design issues; Dual resonance; Electromagnetic simulation; MRI; NMR imaging; Numerical method; RF coil; Volume coil | analytic method; conductance; electric capacitance; electromagnetism; equipment design; geometry; human; magnetic field; mathematical analysis; nonhuman; nuclear magnetic resonance imaging; priority journal; radiofrequency; resonance frequency analysis; Review; theoretical model | English | 2020 | 2020-12 | 10.3390/diagnostics10121017 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Vaginal Microbiome-Based Bacterial Signatures for Predicting the Severity of Cervical Intraepithelial Neoplasia | Although emerging evidence revealed that the gut microbiome served as a tool and as biomarkers for predicting and detecting specific cancer or illness, it is yet unknown if vaginal microbiome-derived bacterial markers can be used as a predictive model to predict the severity of CIN. In this study, we sequenced V3 region of 16S rRNA gene on vaginal swab samples from 66 participants (24 CIN 1-, 42 CIN 2+ patients) and investigated the taxonomic composition. The vaginal microbial diversity was not significantly different between the CIN 1- and CIN 2+ groups. However, we observed Lactobacillus amylovorus dominant type (16.7%), which does not belong to conventional community state type (CST). Moreover, a minimal set of 33 bacterial species was identified to maximally differentiate CIN 2+ from CIN 1- in a random forest model, which can distinguish CIN 2+ from CIN 1- (area under the curve (AUC) = 0.952). Among the 33 bacterial species, Lactobacillus iners was selected as the most impactful predictor in our model. This finding suggests that the random forest model is able to predict the severity of CIN and vaginal microbiome may play a role as biomarker. | Lee, Yoon Hee; Kang, Gi-Ung; Jeon, Se Young; Tagele, Setu Bazie; Pham, Huy Quang; Kim, Min-Sueng; Ahmad, Sajjad; Jung, Da-Ryung; Park, Yeong-Jun; Han, Hyung Soo; Shin, Jae-Ho; Chong, Gun Oh | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Clin Omics Res Ctr, Sch Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41405, South Korea | ; Tagele, Setu Bazie/IYJ-1959-2023; Pham, Quang/AAB-3064-2022 | 37088851700; 57211635810; 57216296837; 57202007103; 57200503445; 57224861638; 57225072939; 57221116102; 56275800900; 7401969388; 57224125922; 23099068000 | mylyh3@naver.com;gukang@knu.ac.kr;amugae1210@knu.ac.kr;setubazie@gmail.com;huypham@knu.ac.kr;chahun4270@knu.ac.kr;sajjadahmedbot1310@gmail.com;yjpark1091@knu.ac.kr;hshan@knu.ac.kr;jhshin@knu.ac.kr;gochong@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 10 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 3.706 | 26.7 | 1.09 | 2025-06-25 | 20 | 21 | cervical intraepithelial neoplasia; machine learning; vaginal microbiome | STREPTOCOCCUS-ANGINOSUS; CANCER; LACTOBACILLUS; DISEASE; WOMEN; SEX; DNA | Cervical intraepithelial neoplasia; Machine learning; Vaginal microbiome | RNA 16S; adult; area under the curve; Article; bioinformatics; controlled study; disease severity; DNA extraction; female; genotyping; human; human tissue; Lactobacillus amylovorus; Lactobacillus iners; major clinical study; microbial diversity; microbiome; middle aged; phylogenetic tree; predictive model; priority journal; random forest; semiconductor sequencing; uterine cervix carcinoma in situ; vagina smear | English | 2020 | 2020-12 | 10.3390/diagnostics10121013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | In the Era of COVID-19: The Role of Spine Surgeons at the Epicenter of the Outbreak | Cho, Dae-Chul | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, 130 Dongdeok Ro, Daegu 41944, South Korea | 55859543400 | dccho@knu.ac.kr; | NEUROSPINE | NEUROSPINE | 2586-6583 | 2586-6591 | 17 | 2 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2020 | 3.492 | 26.8 | 0.31 | 2025-06-25 | 2 | 3 | coronavirus disease 2019; Editorial; elective surgery; epidemic; hand washing; human; intensive care unit; medical staff; occupational hazard; orthopedic surgeon; pneumonia; quarantine; screening; social distance; spine surgery; therapy delay; workplace | English | 2020 | 2020-06 | 10.14245/ns.2040244.122 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Small area estimation of receiver operating characteristic curves for ordinal data under stochastic ordering | There has been a recent increase in the diagnosis of diseases through radiographic images such as x-rays, magnetic resonance imaging, and computed tomography. The outcome of a radiological diagnostic test is often in the form of discrete ordinal data, and we usually summarize the performance of the diagnostic test using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). The ROC curve will be concave and called proper when the outcomes of the diagnostic test in the actually positive subjects are higher than in the actually negative subjects. The diagnostic test for disease detection is clinically useful when a ROC curve is proper. In this study, we develop a hierarchical Bayesian model to estimate the proper ROC curve and AUC using stochastic ordering in several domains when the outcome of the diagnostic test is discrete ordinal data and compare it with the model without stochastic ordering. The model without stochastic ordering can estimate the improper ROC curve with a nonconcave shape or a hook when the true ROC curve of the population is a proper ROC curve. Therefore, the model with stochastic ordering is preferable over the model without stochastic ordering to estimate the proper ROC curve with clinical usefulness for ordinal data. | Jang, Eun Jin; Nandram, Balgobin; Ko, Yousun; Kim, Dal Ho | Andong Natl Univ, Dept Informat Stat, Andong, South Korea; Worcester Polytech Inst, Dept Math Sci, Worcester, MA USA; Seoul Natl Univ, Program Biomed Radiat Sci, Dept Transdisciplinary Studies, Grad Sch Convergence Sci & Technol, Seoul, South Korea; Asan Med Ctr, Asan Inst Life Sci, Biomed Res Ctr, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, 80 Daehak Ro, Daegu 41566, South Korea | 37861741600; 57203092655; 56030047400; 57198636658 | dalkim@knu.ac.kr; | STATISTICS IN MEDICINE | STAT MED | 0277-6715 | 1097-0258 | 39 | 10 | SCIE | MATHEMATICAL & COMPUTATIONAL BIOLOGY;MEDICAL INFORMATICS;MEDICINE, RESEARCH & EXPERIMENTAL;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH;STATISTICS & PROBABILITY | 2020 | 2.373 | 26.8 | 0.62 | 2025-06-25 | 4 | 6 | area under the curve; Bayesian hierarchical model; diagnostic test; grid method; proper ROC curve; stochastic order | MAXIMUM-LIKELIHOOD-ESTIMATION; ROC CURVES; BAYESIAN-ANALYSIS; PARAMETERS; DISTRIBUTIONS; INFERENCE; MODELS | area under the curve; Bayesian hierarchical model; diagnostic test; grid method; proper ROC curve; stochastic order | acute appendicitis; area under the curve; Article; computer assisted tomography; controlled study; diagnostic accuracy; dosimetry; false positive result; human; mathematical analysis; mathematical model; nuclear magnetic resonance imaging; probability; receiver operating characteristic; stochastic model; X ray | English | 2020 | 2020-05-15 | 10.1002/sim.8493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Characterization of Mesenchymal Stem Cells Derived from Patients with Cerebellar Ataxia: Downregulation of the Anti-Inflammatory Secretome Profile | Mesenchymal stem cell (MSC) therapy is a promising alternative approach for the treatment of neurodegenerative diseases, according to its neuroprotective and immunomodulatory potential. Despite numerous clinical trials involving autologous MSCs, their outcomes have often been unsuccessful. Several reports have indicated that MSCs from patients have low capacities in terms of the secretion of neurotrophic or anti-inflammatory factors, which might be associated with cell senescence or disease severity. Therefore, a new strategy to improve their capacities is required for optimal efficacy of autologous MSC therapy. In this study, we compared the secretory potential of MSCs among cerebellar ataxia patients (CA-MSCs) and healthy individuals (H-MSCs). Our results, including secretome analysis findings, revealed that CA-MSCs have lower capacities in terms of proliferation, oxidative stress response, motility, and immunomodulatory functions when compared with H-MSCs. The functional differences were validated in a scratch wound healing assay and neuron-glia co-cultures. In addition, the neuroprotective and immunoregulatory protein follistatin-like 1 (FSTL1) was identified as one of the downregulated proteins in the CA-MSC secretome, with suppressive effects on proinflammatory microglial activation. Our study findings suggest that targeting aspects of the downregulated anti-inflammatory secretome, such as FSTL1, might improve the efficacy of autologous MSC therapy for CA. | Kim, Jong-Heon; Han, Jin; Seo, Donggun; Yoon, Jong Hyuk; Yoon, Dongyeong; Hong, Jungwan; Kim, Sang Ryong; Kim, Min Sung; Lee, Tae Yong; Kim, Kyung Suk; Ko, Pan-Woo; Lee, Ho-Won; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol & Biomed Sci, Daegu 41944, South Korea; Korea Brain Res Inst, Neurodegenerat Dis Res Grp, Daegu 41062, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu 41566, South Korea; Corestem Inc, Bioengn Inst, Seoul 13486, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurol, Daegu 41404, South Korea | han, jin/HGF-2884-2022 | 57203324811; 57218360938; 57207584467; 57212513350; 57214744587; 57196247899; 56486163800; 57218438989; 57205775062; 59082232900; 55543341200; 35337240700; 7005114595 | jongheonkim@knu.ac.kr;jungwan33@naver.com;seodonggun3163@naver.com;jhyoon@kbri.re.kr;ydy10@naver.com;jinhan6628@gmail.com;srk75@knu.ac.kr;mskim@corestem.com;tylee@corestem.com;kskim@corestem.com;panwoo.ko@gmail.com;neuromd@knu.ac.kr;ksuk@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 9 | 1 | SCIE | CELL BIOLOGY | 2020 | 6.6 | 26.9 | 0.33 | 2025-06-25 | 11 | 12 | antiinflammation; cerebellar ataxia; mesenchymal stem cells | FOLLISTATIN-LIKE PROTEIN-1; UMBILICAL-CORD BLOOD; BONE-MARROW; STROMAL CELLS; SPINOCEREBELLAR ATAXIA; ADIPOSE-TISSUE; NEUROINFLAMMATION; TRANSPLANTATION; LIPOCALIN-2; ACTIVATION | Antiinflammation; Cerebellar ataxia; Mesenchymal stem cells | Animals; Cell Proliferation; Cells, Cultured; Cerebellar Ataxia; Down-Regulation; Follistatin-Related Proteins; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Oxidative Stress; antiinflammatory agent; follistatin; growth arrest specific protein 6; somatomedin binding protein 3; transforming growth factor beta receptor; follistatin related protein; Fstl1 protein, mouse; Article; cell aging; cell migration; cell migration assay; cell motility; cell proliferation; cell proliferation assay; cell structure; cerebellar ataxia; clinical outcome; controlled study; disease severity; down regulation; enzyme linked immunosorbent assay; gene ontology; glial cell culture; human; human cell; immunomodulation; mass spectrometry; mesenchymal stem cell; microglia; mRNA expression level; MTT assay; neuroprotection; neurotoxicity; oxidative stress; phase contrast microscopy; reverse transcription polymerase chain reaction; secretomics; validation process; wound healing assay; animal; C57BL mouse; cell culture; cerebellar ataxia; down regulation; mesenchymal stem cell; metabolism; mouse; pathology | English | 2020 | 2020-01 | 10.3390/cells9010212 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Macrophage-Derived Extracellular Vesicle Promotes Hair Growth | Hair loss is a common medical problem affecting both males and females. Dermal papilla (DP) cells are the ultimate reservoir of cells with the potential of hair regeneration in hair loss patients. Here, we analyzed the role of macrophage-derived Wnts (3a and 7b) and macrophage extracellular vesicles (MAC-EVs) in promoting hair growth. We studied the proliferation, migration, and expression of growth factors of human-DP cells in the presence or absence of MAC-EVs. Additionally, we tested the effect of MAC-EV treatment on hair growth in a mouse model and human hair follicles. Data from western blot and flow cytometry showed that MAC-EVs were enriched with Wnt3a and Wnt7b, and more than 95% were associated with their membrane. The results suggest that Wnt proteins in MAC-EVs activate the Wnt/beta-catenin signaling pathways, which leads to activation of transcription factors (Axin2 and Lef1). The MAC-EVs significantly enhanced the proliferation, migration, and levels of hair-inductive markers of DP cells. Additionally, MAC-EVs phosphorylated AKT and increased the levels of the survival protein Bcl-2. The DP cells treated with MAC-EVs showed increased expression of vascular endothelial growth factor (VEGF) and keratinocyte growth factor (KGF). Treatment of Balb/c mice with MAC-EVs promoted hair follicle (HF) growth in vivo and also increased hair shaft size in a short period in human HFs. Our findings suggest that MAC-EV treatment could be clinically used as a promising novel anagen inducer in the treatment of hair loss. | Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Seo, Chang Hoon; Kwack, Mi Hee; Oh, Ji Min; Lee, Ho Won; Gopal, Arunnehru; Sung, Young Kwan; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Dept Biomed Sci, Sch Med, Daegu 41944, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Dept Immunol, Sch Med, Daegu 41944, South Korea | Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021; Lee, Jaetae/ABF-3980-2020; lee, sangwoo/KUD-1906-2024 | 57195318729; 54393130400; 57191539606; 6507685557; 57190370462; 35337240700; 57203278478; 55663365300; 36164032500; 57196249819; 7601451907; 7202791511 | ramyag@knu.ac.kr;prakashg@knu.ac.kr;schch84@dgmif.re.kr;go3004@knu.ac.kr;ojm0366@naver.com;howonlee1234@gmail.com;arunnehru.gopal@gmail.com;ysung@knu.ac.kr;syjeong@knu.ac.kr;swleenm@knu.ac.kr;jaetae@knu.ac.kr;abc2000@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 9 | 4 | SCIE | CELL BIOLOGY | 2020 | 6.6 | 26.9 | 1.89 | 2025-06-25 | 61 | 57 | macrophage; extracellular vesicles; Wnt; beta-catenin signaling; hair follicle; dermal papilla | DERMAL PAPILLA CELLS; ACTIVATES VEGF RECEPTORS; STEM-CELLS; FOLLICLE MORPHOGENESIS; WNT PROTEINS; EXOSOMES; PROLIFERATION; DIFFERENTIATION; REGENERATION; PLUCKING | dermal papilla; extracellular vesicles; hair follicle; macrophage; Wnt; β-catenin signaling | Animals; Biomarkers; Cattle; Cell Movement; Cell Proliferation; Cell Survival; Endocytosis; Extracellular Vesicles; Hair; Intercellular Signaling Peptides and Proteins; Intracellular Membranes; Macrophages; Mice; Mice, Inbred BALB C; RAW 264.7 Cells; Up-Regulation; Wnt Proteins; Wnt Signaling Pathway; biological marker; signal peptide; Wnt protein; animal; Bagg albino mouse; bovine; cell motion; cell proliferation; cell survival; cytology; endocytosis; exosome; growth, development and aging; hair; intracellular membrane; macrophage; metabolism; mouse; RAW 264.7 cell line; ultrastructure; upregulation; Wnt signaling | English | 2020 | 2020-04 | 10.3390/cells9040856 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection | The incidence of ulcerative colitis (UC) is increasing worldwide, and it has become a growing problem in Asia. Previous research on UC has focused on serum, plasma, urine, gut tissues, and fecal metabolic profiling, but a comprehensive investigation into the correlation between the severity of colitis and changes in liver metabolism is still lacking. Since the liver and gut exchange nutrients and metabolites through a complex network, intestinal diseases can affect both the liver and other organs. In the present study, concentration-dependent dextran sodium sulfate (DSS)-induced ulcerative colitis was employed to examine changes in liver metabolism using a proton nuclear magnetic resonance spectroscopy (H-1-NMR)-and ultra-performance liquid chromatography time of flight mass spectroscopy (UPLC-TOF MS)-based metabolomics study. Using the multivariate statistical analysis method orthogonal projections to latent structures discriminant analysis (OPLS-DA), changes in metabolites depending on the DSS dose could be clearly distinguished. Specifically, hepatic metabolites involved in one-carbon metabolism, carnitine-related metabolism, and nucleotide synthesis were found to be affected by intestinal inflammation, implying the existence of a metabolic connection between the gut and liver. We are currently investigating the significance of this metabolic condition in UC. | Kim, Sou Hyun; Lee, Wonho; Kwon, Doyoung; Lee, Seunghyun; Son, Seung Won; Seo, Min-Soo; Kim, Kil Soo; Lee, Yun-Hee; Kim, Suhkmann; Jung, Young-Suk | Pusan Natl Univ, Coll Pharm, Mol Toxicol Lab, Busan 46241, South Korea; Pusan Natl Univ, Dept Chem, Ctr Proteome Biophys, Busan 46241, South Korea; Pusan Natl Univ, Dept Chem, Chem Inst Funct Mat, Busan 46241, South Korea; Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea; Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 08826, South Korea | Lee, Yun-Hee/HZI-7224-2023; Lee, Wonho/AAO-6256-2020; Kim, Sun-Jae/A-1790-2009; Kim, Seung/N-5248-2019 | 57061564500; 57205678296; 57217608273; 57197782444; 57215934212; 35254332100; 35272034300; 55176839300; 7601590816; 56428348300 | hyunie0731@naver.com;wonholee@pusan.ac.kr;Doyoung.Kwon@ucsf.edu;shyun9122@naver.com;wellsu123@naver.com;msseo@dgmif.re.kr;kskim728@knu.ac.kr;yunhee.lee@snu.ac.kr;suhkmann@pusan.ac.kr;youngjung@pusan.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 9 | 2 | SCIE | CELL BIOLOGY | 2020 | 6.6 | 26.9 | 0.78 | 2025-06-25 | 26 | 25 | metabolomics; colitis; gut and liver connection | ACETYL-L-CARNITINE; DISEASE; BETAINE; MICROBIOTA; INJURY; MICE; INFLAMMATION; ENDOTOXEMIA; BIOMARKER; CHOLINE | Colitis; Gut and liver connection; Metabolomics | Acute Disease; Animals; Body Weight; Carnitine; Colitis; Colon; Discriminant Analysis; Disease Models, Animal; Gastrointestinal Tract; Least-Squares Analysis; Liver; Male; Metabolome; Metabolomics; Mice, Inbred BALB C; Multivariate Analysis; Proton Magnetic Resonance Spectroscopy; Rats; Sulfates; carbon; carnitine; dextran sulfate; nucleotide; acylcarnitine; carnitine; sodium sulfate; sulfate; animal experiment; animal model; animal tissue; Article; carbon metabolism; controlled study; dextran sulfate sodium-induced ulcerative colitis; gut and liver connection; infant; intestine; liver; liver metabolism; male; mass spectrometry; metabolite; metabolomics; mouse; nonhuman; nucleotide metabolism; one carbon metabolism; proton nuclear magnetic resonance; ultra performance liquid chromatography; acute disease; animal; Bagg albino mouse; body weight; colitis; colon; discriminant analysis; disease model; gastrointestinal tract; least square analysis; liver; metabolism; metabolome; multivariate analysis; pathology; rat | English | 2020 | 2020-02 | 10.3390/cells9020341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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