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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Genetic landscape and PD-L1 expression in Epstein-Barr virus-associated gastric cancer according to the histological pattern | Epstein-Barr virus ( EBV)-associated gastric cancer (EBVaGC) is a distinct molecular subtype of gastric cancer. This study aims to investigate genomic and clinicopathological characteristics of EBVaGC according to the histological pattern. We retrospectively collected 18 specimens of surgically resected EBVaGCs. Whole-exome sequencing was performed for all cases. Moreover, PD-L1 expression and tumor-infiltrating lymphocyte (TIL) percentage were investigated. Among 18 EBVaGCs, 10 cases were of intestinal histology, 3 were of poorly cohesive histology, and the remaining 5 were of gastric carcinoma with lymphoid stroma histology. Whole-exome sequencing revealed that EBVaGCs with intestinal histology harbored pathogenic mutations known to frequently occur in tubular or papillary adenocarcinoma, including TP53, KRAS, FBXW7, MUC6, ERBB2, CTNNB1, and ERBB2 amplifications. One patient with poorly cohesive carcinoma histology harbored a CDH1 mutation. Patients with EBVaGCs with intestinal or poorly cohesive carcinoma histology frequently harbored driver mutations other than PIK3CA, whereas those with EBVaGCs with gastric carcinoma with lymphoid stroma histology lacked other driver mutations. Moreover, the histological pattern of EBVaGCs was significantly associated with the levels of TILs (P = 0.005) and combined positive score (P = 0.027). In conclusion, patients with EBVaGCs with different histological patterns exhibited distinct genetic alteration, PD-L1 expression, and degree of TILs. | Park, Ji Hyun; Cho, Hee Jin; Seo, Jeonghwa; Park, Ki Bum; Kwon, Yong Hwan; Bae, Han Ik; Seo, An Na; Kim, Moonsik | Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41405, South Korea | Park, Ji/ABG-5893-2020; Kim, Hye/W-1059-2019 | 59284110500; 55937716400; 58686601900; 57220965452; 55775556800; 7103224222; 55804153700; 57195918515 | san_0729@naver.com;teiroa83@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0 | 2025-06-25 | 0 | 0 | CARCINOMA; ADENOCARCINOMA; CHEMOTHERAPY; JUNCTION; GENOME | B7-H1 Antigen; Carcinoma; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Retrospective Studies; Stomach Neoplasms; programmed death 1 ligand 1; carcinoma; complication; Epstein Barr virus; Epstein Barr virus infection; genetics; human; metabolism; pathology; retrospective study; stomach tumor | English | 2023 | 2023-11-09 | 10.1038/s41598-023-45930-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genetic structure analysis and identifying key founder inbred lines in diverse elite sub-tropical maize inbred lines | Understanding the genetic relationships between the key founder inbred lines and derived inbred lines could provide insight into the breeding history and the structure of genetic diversity of the available elite inbred lines with desirable target traits. The maize improvement program at the International Institute of Tropical Agriculture (IITA) analyzed the pedigree information of 623 sub-tropical maize inbred lines generated at the IITA maize breeding program to identify the key founder inbred lines. We also used 5032 SNP markers to assess the genetic similarities of the founder inbred lines with their progenies subsequently developed for specific target traits. The results of pedigree analysis and SNP markers-based similarity scores identified 20 key founder inbred lines with significant contributions to the development of drought tolerant, early maturing, productive, Striga resistant, provitamin A enriched, and quality protein maize inbred lines. In our breeding program, line TZMi501 belonging to a flint heterotic group (HGA), and TZMi407-S and TZMi214, representing the dent heterotic group (HGB), were identified as the most useful founder inbred lines. The 623 inbred lines were consistently separated into four clusters based on Ward's hierarchical clustering, structure, and principal component analyses, with the 20 founder inbred lines spread into all clusters. The founder inbred lines were more genetically related to the productive inbred lines but showed genetic divergence from the provitamin A enriched inbred lines. These results provide a better understanding of the breeding history of the sub-tropical maize inbred lines to facilitate parental selection aligned to existing heterotic groups for use in breeding programs targeting the improvement of essential traits in maize. | Gedil, Melaku; Maazou, Abdoul-Raouf Sayadi; Zebire, Degife A.; Garcia-Oliveira, Ana Luisa; Unachukwu, Nnanna; Petroli, Cesar; Hearne, Sarah; Everett, Leslie A.; Kim, Soon-Kwon; Menkir, Abebe | Int Inst Trop Agr, PMB 5320, Ibadan 200001, Nigeria; Kindo Seeds, Niamey, Niger; Arba Minch Univ, Coll Agr Sci, Dept Plant Sci, Arba Minch, Ethiopia; Int Maize & Wheat Improvement Ctr, Excellence Breeding, Ibadan, Nigeria; Int Maize & Wheat Improvement Ctr, Carretera Mexico Veracruz Km 45 El Batan, Texcoco 56237, Mexico; Int Maize & Wheat Improvement Ctr, Nairobi, Kenya; CCS Haryana Agr Univ, Coll Basic Sci & Humanities, Dept Mol Biol Biotechnol & Bioinformat, Hisar, Haryana, India; Univ Minnesota, Dept Agron & Plant Genet, 411 Borlaug Hall,1991 Upper Buford Circle, St Paul, MN 55108 USA; Kyungpook Natl Univ, Daegu, South Korea; Int Corn Fdn, Seoul, South Korea | SAYADI MAAZOU, ABDOUL RAOUF/IAM-4058-2023; Zebire, Degife/AAG-5223-2021; Garcia-Oliveira, Ana/AAN-8324-2020; Gedil, Melaku/H-9445-2019 | 8917898700; 57299991800; 57192266444; 25947356600; 57194606545; 33767992800; 35725453400; 8688517600; 57007269300; 6701494488 | m.gedil@cgiar.org; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0 | 2025-06-25 | 1 | 0 | DENT CORN; GERMPLASM; PEDIGREE; REGISTRATION; SOFTWARE; TRAITS; RFLP | English | 2023 | 2023-07-20 | 10.1038/s41598-023-38980-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Genotype-phenotype correlation of X-linked Alport syndrome observed in both genders: a multicenter study in South Korea | The genotype-phenotype correlation of the X-linked Alport syndrome (XLAS) has been well elucidated in males, whereas it remains unclear in females. In this multicenter retrospective study, we analyzed the genotype-phenotype correlation in 216 Korean patients (male:female = 130:86) with XLAS between 2000 and 2021. The patients were divided into three groups according to their genotypes: the non-truncating group, the abnormal splicing group, and the truncating group. In male patients, approximately 60% developed kidney failure at the median age of 25.0 years, and kidney survival showed significant differences between the non-truncating and truncating groups (P < 0.001, hazard ratio (HR) 2.8) and splicing and truncating groups (P = 0.002, HR 3.1). Sensorineural hearing loss was detected in 65.1% of male patients, while hearing survival periods showed a highly significant difference between the non-truncating and truncating groups (P < 0.001, HR 5.1). In female patients, approximately 20% developed kidney failure at the median age of 50.2 years. The kidney survival was significantly different between the non-truncating and truncating groups (P = 0.006, HR 5.7). Our findings support the presence of genotype-phenotype correlation not only in male patients but also in female patients with XLAS. | Kim, Ji Hyun; Lim, Seon Hee; Song, Ji Yeon; Cho, Myung Hyun; Hyun, HyeSun; Yang, Eun Mi; Lee, Jung Won; Cho, Min Hyun; Park, Min Ji; Lee, Joo Hoon; Jung, Jiwon; Yoo, Kee Hwan; Jang, Kyung Mi; Pai, Ki Soo; Suh, Jin-Soon; Namgoong, Mee Kyung; Chung, Woo Yeong; Kim, Su Jin; Cho, Eun Young; Kim, Kyung Min; Kim, Nam Hee; Kim, Minsun; Paik, Jin Ho; Kang, Hee Gyung; Ahn, Yo Han; Cheong, Hae Il | Seoul Natl Univ, Bundang Hosp, Dept Pediat, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea; Pusan Natl Univ, Dept Pediat, Yangsan Childrens Hosp, Yangsan, South Korea; Sch Med, Yangsan, South Korea; Hallym Univ, Dept Pediat, Sacred Heart Hosp, Anyang, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Chonnam Natl Univ, Dept Pediat, Gwangju, South Korea; Sch Med, Gwangju, South Korea; Ewha Womans Univ, Sch Med, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pediat, Coll Med,Childrens Hosp, Seoul, South Korea; Woori Childrens Hosp, Dept Nephrol, Seoul, South Korea; Yeungnam Univ, Dept Pediat, Coll Med, Gyongsan, South Korea; Ajou Univ, Dept Pediat, Sch Med, Suwon, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Pediat, Bucheon St, Seoul, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Pediat, Wonju Coll Med, Wonju, South Korea; WooYeong Chung Pediat Clin, Busan, South Korea; Inha Univ, Inha Univ Hosp, Dept Pediat, Coll Med, Incheon, South Korea; Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea; Inje Univ, Dept Pediat, Ilsan Paik Hosp, Goyang, South Korea; Jeonbuk Natl Univ, Dept Pediat, Med Sch, Jeonju, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Seongnam, South Korea; Seoul Natl Univ, Dept Pediat, Childrens Hosp, Seoul, South Korea; Seoul Natl Univ, Kidney Res Inst, Med Res Ctr, Seoul, South Korea; Seoul Red Cross Hosp, Dept Pediat, Seoul, South Korea | ; Kim, Nam-Hee/GVU-3400-2022; Jung, JiWon/AAF-6236-2020; Cheong, Hae/J-5652-2012; Suh, Jin-Soon/GNH-6543-2022; cho, myung hyun/AEB-7941-2022 | 58607599100; 57200387334; 57204058871; 57203276948; 57204538255; 56665095200; 26028875500; 7401727726; 57425372600; 37112404100; 56518750800; 7202592702; 57203762745; 17137435400; 35222513700; 8605958900; 8605959600; 57203773231; 56426759100; 57218587004; 57220797162; 57839441000; 7102939635; 7404071546; 57219957477; 57265727700 | yhahn@snu.ac.kr;cheonghi@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.94 | 2025-06-25 | 4 | 8 | NATURAL-HISTORY; 195 FAMILIES; VARIANTS | Collagen Type IV; Female; Genetic Association Studies; Humans; Male; Mutation; Nephritis, Hereditary; Phenotype; Renal Insufficiency; Retrospective Studies; collagen type 4; clinical trial; female; genetic association study; genetics; human; kidney failure; male; multicenter study; mutation; nephritis; phenotype; retrospective study | English | 2023 | 2023-04-26 | 10.1038/s41598-023-34053-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients | Vitamin D-3 (25[OH]D-3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes and vitamin D insufficiency after KT. This study investigated the effect of pretransplant FGF23 levels on post-KT 25(OH)D-3 status and graft outcomes. Serum FGF23 levels from 400 participants of the KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation were measured. Annual serum 25(OH)D-3 levels, all-cause mortality, cardiovascular event, and graft survival were assessed according to baseline FGF23 levels. Serum 25(OH)D-3 levels were initially increased 1 year after KT (12.6 +/- 7.4 vs. 22.6 +/- 6.4 ng/mL). However, the prevalence of post-KT vitamin D deficiency increased again after post-KT 3 years (79.1% at baseline, 30.8% and 37.8% at 3 and 6 years, respectively). Serum FGF23 level was decreased 3 years post-KT. When participants were categorized into tertiles according to baseline FGF23 level (low, middle, high), 25(OH)D-3 level in the low FGF23 group was persistently low at a median follow-up of 8.3 years. Furthermore, high baseline FGF23 level was a risk factor for poor graft survival (HR 5.882, 95% C.I.; 1.443-23.976, P=0.013). Elevated FGF23 levels are associated with persistently low post-transplant vitamin D levels and poor graft survival. | Ryu, Jung-Hwa; Jeon, Hee Jung; Han, Ro; Jung, Hee-Yeon; Kim, Myung-Gyu; Huh, Kyu Ha; Park, Jae Berm; Kang, Kyung Pyo; Han, Seungyeup; Yang, Jaeseok | Ewha Womans Univ, Dept Internal Med, Seoul Hosp, Seoul, South Korea; Hallym Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Seoul Samsung Med Ctr, Dept Surg, Seoul, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea | Kang, Kyung Pyo/ABG-3614-2020; Yang, Jae/LUW-8250-2024; Jung, Hee-Yeon/AFB-8578-2022; Han, Seung Seok/HGD-2825-2022 | 14621981000; 57206189475; 58068544800; 57196396467; 36183208900; 35183155900; 13605451500; 7402223564; 24281360600; 57212326527 | jcyjs@yuhs.ac; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.24 | 2025-06-25 | 0 | 2 | GROWTH-FACTOR 23; LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR EVENTS; POSTTRANSPLANT HYPOPHOSPHATEMIA; MINERAL METABOLISM; MORTALITY; DISEASE; FGF-23; PHOSPHORUS; FACTOR-23 | Cohort Studies; Fibroblast Growth Factors; Graft Survival; Humans; Kidney Transplantation; Vitamin D; Vitamin D Deficiency; Vitamins; fibroblast growth factor; vitamin; vitamin D; cohort analysis; graft survival; human; kidney transplantation; vitamin D deficiency | English | 2023 | 2023-11-10 | 10.1038/s41598-023-46889-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact of iron status on kidney outcomes in kidney transplant recipients | Iron plays an important role in hemodynamics and the immunity, independent of anemia. Since dynamic changes occur in iron storage after kidney transplantation (KT), we investigated the association between iron status and kidney outcomes in KT patients. We analyzed data from the KoreaN cohort study for Outcome in patients With KT (KNOW-KT). The iron status was classified into three groups based on ferritin or transferrin saturation (TSAT) levels one year after KT, with reference ranges of 20-35% and 100-300 ng/mL for TSAT and ferritin, respectively. The primary outcome was the composite outcome, which consisted of death, graft failure, and an estimated glomerular filtration rate decline >= 50%. In total, 895 patients were included in the final analysis. During a median follow-up of 5.8 years, the primary outcome occurred in 94 patients (19.8/1000 person-years). TSAT levels decreased one year after KT and thereafter gradually increased, whereas ferritin levels were maintained at decreased levels. The adjusted hazard ratios (95% confidence intervals) for the composite outcome were 1.67 (1.00-2.77) and 1.20 (0.60-2.40) in the TSAT > 35% and ferritin > 300 ng/mL groups, respectively. High iron status with high TSAT levels increases the risk of graft failure or kidney functional deterioration after KT. | Kim, Hyo Jeong; Han, Ro; Kang, Kyung Pyo; Ryu, Jung-Hwa; Kim, Myung-Gyu; Huh, Kyu Ha; Park, Jae Berm; Kim, Chan-Duck; Han, Seungyeup; Kim, Hyung Woo; Kim, Beom Seok; Yang, Jaeseok | Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Coll Med, Incheon, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Dept Internal Med, Med Sch, Jeonju, South Korea; Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju, South Korea; Ewha Womans Univ, Dept Internal Med, Seoul Hosp, Seoul, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Seoul Samsung Med Ctr, Dept Surg, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Div Nephrol, 50 Yonsei Ro, Seoul 03722, South Korea | Han, Seung Seok/HGD-2825-2022; Kim, Soo-Yeon/ADR-9663-2022; Kim, Sun Jung/AAM-7334-2020; Kang, Kyung Pyo/ABG-3614-2020; Kim, Hyung Woo/ABW-5643-2022; Yang, Jae/LUW-8250-2024 | 57476930200; 58068544800; 7402223564; 14621981000; 36183208900; 35183155900; 13605451500; 8558530700; 24281360600; 57226441883; 56127911000; 57212326527 | jcyjs@yuhs.ac; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 3 | 3 | RENAL-ALLOGRAFT SURVIVAL; TRANSFERRIN SATURATION; SERUM CREATININE; ANEMIA; OVERLOAD; MORTALITY; ASSOCIATION; HOMEOSTASIS; PROGRESSION; REJECTION | Cohort Studies; Ferritins; Humans; Iron; Kidney; Kidney Transplantation; Transferrin; ferritin; iron; transferrin; adverse event; chemistry; cohort analysis; human; kidney; kidney transplantation | English | 2023 | 2023-01-17 | 10.1038/s41598-023-28125-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact on quality of life with affirmative feedback on weight loss after gastrectomy | This study investigated the feasibility of improving post-gastrectomy satisfaction/quality of life (QoL) of gastric cancer survivors by readjusting their expectations through patient interviews. Weight loss after gastric cancer surgery is common, and a change in the departmental policy helped in providing cancer survivors with an alternative interpretation of lost weight. Under the new policy, a group of patients who were preoperatively overweight or obese were provided with affirmative feedback, despite their postoperative weight loss. The European Organization for Research and Treatment of Cancer QoL Questionnaire-C30 and -STO22 were used to assess the QoL. The postoperative 1-year QoL was compared before (control) and after policy changes (affirmative-feedback group) in preoperatively overweight (or obese) patients who lost weight. Despite the weight loss, the affirmative-feedback group exhibited a higher percentage of "less worried" responses (90.4%) on low body weight concerns as compared to the control group (76.5%; P = 0.037). Significant QoL advantages were also observed in the affirmative-feedback group on multiple scales (global health status/QoL, nausea/vomiting, diarrhea, dysphagia, dry mouth, and body image). Patient interviews with affirmative feedback on weight loss improved weight satisfaction and QoL in gastric cancer survivors who lost weight. | Lee, Seung Soo; Chung, Ho Young; Kwon, Oh Kyoung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, 130 Dongdeok Ro, Daegu 700721, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea | 54400392100; 56008255800; 26536109900 | hychung@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.12 | 2025-06-25 | 1 | 1 | EARLY GASTRIC-CANCER; DISTAL GASTRECTOMY; POSTGASTRECTOMY SYNDROMES; NUTRITIONAL-STATUS; ADENOCARCINOMA; SURGERY | Feedback; Gastrectomy; Humans; Obesity; Overweight; Quality of Life; Stomach Neoplasms; Weight Loss; body weight loss; feedback system; gastrectomy; human; obesity; quality of life; stomach tumor | English | 2023 | 2023-09-18 | 10.1038/s41598-023-42695-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Implication of high variance in germplasm characteristics | The beauty of conserving germplasm is the securement of genetic resources with numerous important traits, which could be utilized whenever they need to be incorporated into current cultivars. However, it would not be as useful as expected if the proper information was not given to breeders and researchers. In this study, we demonstrated that there is a large variation, both among and within germplasm, using a low-cost image-based phenotyping method; this could be valuable for improving gene banks' screening systems and for crop breeding. Using the image analyses of 507 accessions of buckwheat, we identified a wide range of variations per trait between germplasm accessions and within an accession. Since this implies a similarity with other important agronomic traits, we suggest that the variance of the presented traits should be checked and provided for better germplasm enhancement. | Yu, Ju-Kyung; Chang, Sungyul; Han, Gyung Deok; Kim, Seong-Hoon; Ahn, Jinhyun; Park, Jieun; Kim, Yoonha; Kim, Jaeyoung; Chung, Yong Suk | Syngenta Crop Protect LLC, Seeds Res, Durham, NC 27709 USA; RDA, Natl Inst Crop Sci, Crop Protect & Physiol Div, Wonju 55365, South Korea; Cheongju Natl Univ Educ, Dept Pract Course Educ, Cheongju 28708, South Korea; RDA, Natl Inst Agr Sci NAS, Natl Agrobiodivers Ctr, Jeonju, South Korea; Jeju Natl Univ, Dept Management Informat Syst, Jeju 63243, South Korea; Jeju Natl Univ, Dept Plant Resources & Environm, Jeju 63243, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Natl Inst Agr Sci, Gene Engn Div, Jeonju 54874, South Korea | JIEUN, PARK/KBP-9718-2024; Chung, Yong/V-6909-2019; Yu, Ju-Kyung/HCH-4393-2022; Kim, Seong-Hoon/AHE-2059-2022 | 7405526081; 59055507400; 57191094095; 57208236056; 56621886700; 57225103839; 57224866763; 58060905400; 36983850100 | yschung@jejunu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.24 | 2025-06-25 | 2 | 2 | Genetic Variation; Phenotype; Plant Breeding; agronomic trait; article; breeding; buckwheat; crop; germplasm; human; human experiment; image analysis; nonhuman; phenotype; genetic variation; plant breeding | English | 2023 | 2023-01-10 | 10.1038/s41598-023-27793-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Improving the photoelectrochemical water splitting performance of CuO photocathodes using a protective CuBi2O4 layer | A heterojunction photocathode of CuO and CuBi2O4 grown on an FTO substrate (FTO/CuO/CuBi2O4) was synthesized using hydrothermal method followed by spin coating and annealing to overcome the bottlenecks encountered by CuO in photoelectrochemical (PEC) water splitting application. The synthesis methods, morphological, structural properties, and composition of each sample under each synthesis condition are discussed in detail. The photocathode with 15 coating layers annealed at 450 degrees C exhibited the best PEC performance. Moreover, its current density reached 1.23 mA/cm(2) under an applied voltage of - 0.6 V versus Ag/AgCl in a neutral electrolyte. Additionally, it exhibited higher stability than the bare CuO thin film. The bonding of CuBi2O4 on CuO resulted in close contact between the two semiconductors, helping the semiconductors support each other to increase the PEC efficiency of the photocathode. CuO acted as the electron-generating layer, and the CuBi2O4 layer helped minimize photocorrosion as well as transport the carriers to the electrode/electrolyte interface to accomplish the hydrogen evolution reaction. | Lam, Nguyen Hoang; Truong, Nguyen Tam Nguyen; Le, Nam; Ahn, Kwang-Soon; Jo, Younjung; Kim, Chang-Duk; Jung, Jae Hak | Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | Nguyen, Anh Tuan/GXF-6089-2022; Lam, Nguyen/KRO-9111-2024 | 58313026700; 25958384000; 57212150973; 7202870619; 13502586500; 57200982445; 13308234300 | tamnguyentn@ynu.ac.kr;duks@knu.ac.kr;jhjung@ynu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 2.6 | 2025-06-25 | 26 | 22 | P-TYPE CUBI2O4; HYDROTHERMAL METHOD; HYDROGEN EVOLUTION; HETEROJUNCTION; STABILITY; FABRICATION; REDUCTION; CRYSTAL | English | 2023 | 2023-04-08 | 10.1038/s41598-023-32804-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | In vivo imaging of renal microvasculature in a murine ischemia-reperfusion injury model using optical coherence tomography angiography | Optical coherence tomography angiography (OCTA) provides three-dimensional structural and semiquantitative imaging of microvasculature in vivo. We developed an OCTA imaging protocol for a murine kidney ischemia-reperfusion injury (IRI) model to investigate the correlation between renal microvascular changes and ischemic damage. Mice were divided into mild and moderate IRI groups according to the duration of ischemia (10 and 35 mins, respectively). Each animal was imaged at baseline; during ischemia; and at 1, 15, 30, 45, and 60 mins after ischemia. Amplitude decorrelation OCTA images were constructed with 1.5-, 3.0-, and 5.8-ms interscan times, to calculate the semiquantitative flow index in the superficial (50-70 mu m) and the deep (220-340 mu m) capillaries of the renal cortex. The mild IRI group showed no significant flow index change in both the superfial and the deep layers. The moderate IRI group showed a significantly decreased flow index from 15 and 45 mins in the superficial and deep layers, respectively. Seven weeks after IRI induction, the moderate IRI group showed lower kidney function and higher collagen deposition than the mild IRI group. OCTA imaging of the murine IRI model revealed changes in superficial blood flow after ischemic injury. A more pronounced decrease in superficial blood flow than in deep blood flow was associated with sustained dysfunction after IRI. Further investigation on post-IRI renal microvascular response using OCTA may improve our understanding of the relationship between the degree of ischemic insult and kidney function. | Lee, ByungKun; Kang, Woojae; Oh, Se-Hyun; Cho, Seungwan; Shin, Inho; Oh, Eun-Joo; Kim, You-Jin; Ahn, Ji-Sun; Yook, Ju-Min; Jung, Soo-Jung; Lim, Jeong-Hoon; Kim, Yong-Lim; Cho, Jang-Hee; Oh, Wang-Yuhl | Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon, South Korea; Korea Adv Inst Sci & Technol, KI Hlth Sci & Technol, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Div Nephrol, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea | ; Cho, Jang-hee/ABD-3534-2020; Oh, Wang-Yuhl/C-2055-2011; Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020 | 56313470700; 57201462435; 56053033900; 58190000500; 57217084022; 35783223700; 57190286137; 57191631694; 35110084800; 57193347340; 55360244300; 55633533600; 7403536291; 24438242500 | jh-cho@knu.ac.kr;woh1@kaist.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 3 | 3 | ACUTE KIDNEY INJURY; ENDOTHELIAL GROWTH-FACTOR; IMPAIRED ANGIOGENESIS; COMPUTED-TOMOGRAPHY; BLOOD-FLOW; MICROANGIOGRAPHY; RAREFACTION; DYSFUNCTION; PERFUSION; AKI | Angiography; Animals; Ischemia; Kidney; Mice; Microvessels; Reperfusion Injury; Tomography, Optical Coherence; angiography; animal; complication; diagnostic imaging; ischemia; kidney; microvasculature; mouse; optical coherence tomography; reperfusion injury; vascularization | English | 2023 | 2023-04-19 | 10.1038/s41598-023-33295-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Long COVID prevalence and impact on quality of life 2 years after acute COVID-19 | There has been an increasing interest in the long-term impact of long COVID. However, only a few studies have investigated the clinical manifestations of long COVID after 24 months of acute infection. In this study, prospective online surveys were conducted in adults previously diagnosed with coronavirus disease 2019 (COVID-19) in South Korea between February 13 and March 13, 2020, at 6, 12, and 24 months after COVID-19. We investigated self-reported symptoms and the EuroQol-5-dimension index. Among 900 individuals enrolled initially, 150 completed all 3 surveys. After excluding the cases of COVID-19 reinfection, 132 individuals were included in the final analysis. Among the 132 participants, 94 (71.2%) experienced symptoms of long COVID. The most frequently reported symptoms were fatigue (34.8%), amnesia (30.3%), concentration difficulties (24.2%), insomnia (20.5%), and depression (19.7%). Notably, no significant differences were noted in the incidence of long COVID at 24 months in terms of the number of vaccinations received. Although the neuropsychiatric quality of life improved over time, it continued to affect 32.7% of participants. Symptoms of long COVID, particularly neuropsychiatric symptoms, tend to persist over time, and COVID-19 vaccination or the number of vaccinations received may not significantly affect the incidence of long COVID. | Kim, Yoonjung; Bae, Sohyun; Chang, Hyun-Ha; Kim, Shin-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, 130, Dongdeok Ro, Daegu 41944, South Korea | Kim, Sooyeon/AAA-8521-2022; Kim, Ji Hoon/AAB-4602-2022 | 57203160508; 57219699506; 7407521688; 57189703358 | ksw2kms@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 10.15 | 2025-06-25 | 90 | 88 | Adult; COVID-19; COVID-19 reinfection; COVID-19 Vaccines; Humans; Post-Acute COVID-19 Syndrome; Prevalence; Prospective Studies; Quality of Life; SARS-CoV-2 vaccine; adult; coronavirus disease 2019; human; long COVID; prevalence; prospective study; quality of life | English | 2023 | 2023-07-11 | 10.1038/s41598-023-36995-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Correction | Long COVID prevalence and impact on quality of life 2 years after acute COVID-19 (vol 13, 11207, 2023) | Kim, Yoonjung; Bae, Sohyun; Chang, Hyun-Ha; Kim, Shin-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130, Dongdeok ro, Daegu 41944, South Korea | ; Kim, Ji Hoon/AAB-4602-2022; Kim, Sooyeon/AAA-8521-2022 | 57203160508; 57219699506; 7407521688; 57189703358 | ksw2kms@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 14.09 | 2025-06-25 | 2 | 4 | erratum | English | 2023 | 2023-07-24 | 10.1038/s41598-023-39132-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Long-term findings of rectal endoscopy and rectal bleeding after moderately hypofractionated, intensity-modulated radiotherapy for prostate cancer | To present rectal endoscopic findings and toxicity after definitive moderately hypofractionated, intensity-modulated radiotherapy (IMRT) for prostate cancer. We retrospectively reviewed patients who underwent IMRT for prostate cancer and underwent post-radiotherapy endoscopies between 2008 and 2018. Endoscopic findings were reviewed and graded using Vienna Rectoscopy Score (VRS). We have analyzed the association between endoscopic findings and rectal bleeding, and investigated risk factors for rectal bleeding. Total 162 patients met the inclusion criteria of this study. There was a trend of VRS worsening during the initial 3 years after radiotherapy followed by recovery. Rectal bleeding was highest at 1 year after radiotherapy and improved thereafter. The 5-year cumulative incidence of grade >= 2 rectal bleeding was 14.8%. In the multivariable Cox regression analysis, cardiovascular disease (hazard ratio [HR] 2.732, P = 0.037), rectal wall V65 (HR 1.158, P = 0.027), and VRS >= 3 in first post-radiotherapy endoscopy (HR 2.573, P = 0.031) were significant risk factors for rectal bleeding. After IMRT for prostate cancer, VRS and rectal bleeding worsened over 1-3 years after radiotherapy and recovered. Cardiovascular disease, rectal wall V65, and VRS >= 3 in first post-radiotherapy endoscopy were significant risk factors for rectal bleeding. | Bae, Bong Kyung; Kim, Ji Eun; Pyo, Hongryull; Hong, Sung Noh; Park, Won | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiat Oncol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu, South Korea | Kim, Ji/J-5440-2012; Hong, Sung Noh/MTB-0511-2025 | 57191481610; 57191682217; 55655325100; 57220761219; 55663053400 | wonro.park@samsung.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 2 | 3 | EXTERNAL-BEAM RADIOTHERAPY; CONVENTIONAL RADIOTHERAPY; RECTAL/URINARY TOXICITY; CONFORMAL RADIOTHERAPY | Cardiovascular Diseases; Gastrointestinal Hemorrhage; Humans; Male; Proctoscopy; Prostatic Neoplasms; Radiation Injuries; Radiotherapy, Intensity-Modulated; Rectum; Retrospective Studies; cardiovascular disease; complication; gastrointestinal hemorrhage; human; intensity modulated radiation therapy; male; prostate tumor; radiation injury; rectoscopy; rectum; retrospective study | English | 2023 | 2023-12-13 | 10.1038/s41598-023-43202-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Machine learning based prediction for oncologic outcomes of renal cell carcinoma after surgery using Korean Renal Cell Carcinoma (KORCC) database | We developed a novel prediction model for recurrence and survival in patients with localized renal cell carcinoma (RCC) after surgery and a novel statistical method of machine learning (ML) to improve accuracy in predicting outcomes using a large Asian nationwide dataset, updated KOrean Renal Cell Carcinoma (KORCC) database that covered data for a total of 10,068 patients who had received surgery for RCC. After data pre-processing, feature selection was performed with an elastic net. Nine variables for recurrence and 13 variables for survival were extracted from 206 variables. Synthetic minority oversampling technique (SMOTE) was used for the training data set to solve the imbalance problem. We applied the most of existing ML algorithms introduced so far to evaluate the performance. We also performed subgroup analysis according to the histologic type. Diagnostic performances of all prediction models achieved high accuracy (range, 0.77-0.94) and F1-score (range, 0.77-0.97) in all tested metrics. In an external validation set, high accuracy and F1-score were well maintained in both recurrence and survival. In subgroup analysis of both clear and non-clear cell type RCC group, we also found a good prediction performance. | Kim, Jung Kwon; Lee, Sangchul; Hong, Sung Kyu; Kwak, Cheol; Jeong, Chang Wook; Kang, Seok Ho; Hong, Sung-Hoo; Kim, Yong-June; Chung, Jinsoo; Hwang, Eu Chang; Kwon, Tae Gyun; Byun, Seok-Soo; Jung, Yu Jin; Lim, Junghyun; Kim, Jiyeon; Oh, Hyeju | Seoul Natl Univ, Bundang Hosp, Dept Urol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Urol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Urol, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Urol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Urol, Seoul, South Korea; Chungbuk Natl Univ Hosp, Dept Urol, Cheongju, South Korea; Natl Canc Ctr, Dept Urol, Goyang, South Korea; Chonnam Natl Univ, Med Sch, Dept Urol, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Urol, Daegu, South Korea; Seoul Natl Univ, Coll Med, Dept Med Device Dev, Seoul, South Korea; IMC Lnc, Daegu, South Korea | ; Byun, Seok-Soo/J-5507-2012; Hwang, Eu/K-3680-2019; Kim, Yong-June/E-5622-2012; Lim, Junghyun/AAX-3678-2021; Kwak, Cheol/J-2731-2012; Hong, Sung/J-5722-2012 | 36447570600; 57202327303; 24468238500; 7005639032; 8879131000; 7405684686; 37030299600; 26422204800; 16678454900; 8441681300; 15073765400; 7004818488; 58066064500; 58175581000; 58176280100; 58176280200 | ssbyun@snubh.org; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.83 | 2025-06-25 | 6 | 7 | POSTOPERATIVE PROGNOSTIC NOMOGRAM; MODEL; CLASSIFICATION; VALIDATION; SELECTION | Algorithms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Machine Learning; Republic of Korea; Retrospective Studies; algorithm; epidemiology; human; kidney tumor; machine learning; pathology; renal cell carcinoma; retrospective study; South Korea | English | 2023 | 2023-04-08 | 10.1038/s41598-023-30826-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Macrophage induces anti-cancer drug resistance in canine mammary gland tumor spheroid | Tumor-associated macrophages (TAMs) play an important role in the tumor microenvironment by producing cytokines and growth factors. Furthermore, TAMs play multifunctional roles in tumor progression, immune regulation, metastasis, angiogenesis, and chemoresistance. Hypoxia in the tumor microenvironment induces tumor-supporting transformation of TAMs, which enhances tumor malignancy through developing anti-cancer resistance, for example. In this study, a hybrid spheroid model of canine mammary gland tumor (MGT) cell lines (CIPp and CIPm) and canine macrophages (DH82) was established. The effects of hypoxia induced by the spheroid culture system on the anti-cancer drug resistance of canine MGT cells were investigated. A hybrid spheroid was created using an ultralow-adhesion plate. The interactions between canine MGT cells and DH82 were investigated using a co-culture method. When co-cultured with DH82, cell viability and expression levels of tumor growth factors and multi-drug resistance genes were increased in canine MGT cells under doxorubicin. Additionally, doxorubicin-induced apoptosis and G2/M cell cycle arrest were attenuated in canine MGT cells co-cultured with DH82. In conclusion, the hybrid spheroid model established in this study reflects the hypoxic TME, allowing DH82 to induce anti-cancer drug resistance in canine MGT cells. | Lim, Ga-Hyun; An, Ju-Hyun; Park, Su-Min; Youn, Ga-Hee; Oh, Ye-In; Seo, Kyoung-Won; Youn, Hwa-Young | Seoul Natl Univ, Dept Vet Clin Sci, Coll Vet Med, Lab Vet Internal Med, Seoul 08826, South Korea; Kangwon Natl Univ, Inst Vet Sci, Dept Vet Emergency & Crit Care Med, Coll Vet Med, Chuncheon Si, South Korea; Kyungpook Natl Univ, Dept Vet Internal Med, Coll Vet Med, Daegu, South Korea | Seo, Kwang/AAB-4821-2020 | 58132315300; 57206839650; 57211909684; 58414189500; 36466903200; 8833507700; 7102027331 | hyyoun@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.71 | 2025-06-25 | 6 | 6 | BREAST-CANCER; CYCLIN D1; HYPOXIA; CELL; APOPTOSIS; PROLIFERATION; EXPRESSION; DOGS; POLARIZATION; PLASTICITY | Animals; Antineoplastic Agents; Dogs; Doxorubicin; Drug Resistance, Neoplasm; Hypoxia; Macrophages; Tumor Microenvironment; antineoplastic agent; doxorubicin; animal; dog; drug resistance; hypoxia; macrophage; metabolism; tumor microenvironment | English | 2023 | 2023-06-27 | 10.1038/s41598-023-37311-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | More than unfamiliar environmental connection to super typhoon climatology | This study employs a refined geometric variability model to look at the environmental relationship to super typhoon climatology, which is one of the major concerns about climate change and disasters. It is noted that adding only several recent years leads to a remarkable weakening of the environmental explanatory power on super typhoon climatology. Looking into the annual covariance elements, we find that the recent observations showing a group of outlying events with a particular drift are more than unfamiliar compared to the former stable relationship from 1985 through 2012. Greater uncertainty thereby amplifies concerns about the looming climate crisis. | Kang, Namyoung; Jang, Chan Joo; Elsner, James B. | Kyungpook Natl Univ, Dept Geog, Daegu 41566, South Korea; Univ Sci & Technol, Dept Oceanog, Daejeon 34113, South Korea; Korea Inst Ocean Sci & Technol, Ocean Circulat Res Div, Busan 49111, South Korea; Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA | 54580993100; 7103149678; 7102949838 | nkang4@knu.ac.kr;jelsner@fsu.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0 | 2025-06-25 | 1 | 0 | SEA-SURFACE TEMPERATURE; TROPICAL CYCLONES; TIPPING POINTS; FREQUENCY; INTENSITY; ENERGY; ENSO | article; climate change; covariance; disaster; hurricane; uncertainty | English | 2023 | 2023-04-19 | 10.1038/s41598-023-33104-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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