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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Satellite-Estimated Microwave Emissivity and Emission Temperature Over the Arctic Sea Ice: ANN-Based Algorithm | Satellite microwave surface-sensitive sounding channels have long faced limitations in polar data assimilation (DA) due to difficulties in specifying radiative boundary conditions over sea ice, particularly during winter. Previous studies have proposed using outputs from sea-ice growth model to estimate microwave emissivities and emission temperatures for DA. However, this approach poses practical challenges, as it operates independently of numerical weather prediction systems. To overcome these challenges, this study introduces an artificial neural network (ANN) technique that transforms the modeling approach into an algorithm capable of directly retrieving radiative boundary conditions from satellite observations. The ANN leverages empirical knowledge that sea-ice emissivity is closely related to ice type and that microwave penetration depth varies with frequency, capturing temperature profiles within sea ice. It targets winter Arctic Ocean, using brightness temperatures (TBs) from ATMS channels 1 to 3 (23, 36, and 51 GHz) as inputs to retrieve emissivity and emission temperature for surface-sensitive channels 6 and 7 (53 and 54 GHz). The ANN algorithm was trained and validated using simulated data sets, demonstrating high accuracy with correlation coefficients of 0.99 and low errors. Further evaluation using ATMS observations from the winters of 2021 and 2022 was conducted by converting the retrievals into top-of-atmosphere TBs, yielding consistent error statistics: correlation coefficients of 0.99, mean deviations of about −0.3 K, and standard deviations of about 0.3 K for both channels. These results confirm the algorithm's stability and robust generalization capabilities, underscoring its potential for integration within DA systems and broader applications to other microwave sensors. © 2025. The Author(s). | Kang, Eui-Jong; Sohn, Byung-Ju; Song, Hwan-Jin; Liu, Chao | School of Earth and Environmental Sciences, Seoul National University (SNU), Seoul, South Korea; School of Earth and Environmental Sciences, Seoul National University (SNU), Seoul, South Korea, School of Atmospheric Physics, Nanjing University of Information Science and Technology (NUIST), Nanjing, China; Department of Atmospheric Sciences, KNU G-LAMP Project Group, Kyungpook National University (KNU), Daegu, South Korea; School of Atmospheric Physics, Nanjing University of Information Science and Technology (NUIST), Nanjing, China | 57220008112; 7005650812; 55331697200; 56939103900 | sohn@snu.ac.kr; | Journal of Geophysical Research: Atmospheres | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 130 | 9 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 3.4 | 37.4 | N/A | 0 | artificial neural network; emission temperature; emissivity; microwave; surface radiative boundary conditions; winter Arctic sea ice | Arctic Ocean; artificial neural network; boundary condition; data assimilation; microwave radiation; satellite data; sea ice; top of atmosphere | English | Final | 2025 | 10.1029/2024jd042265 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Article | Longitudinal Analysis of Recurrence and Risk Factors of Early-Stage Resected Adenocarcinoma With Common EGFR Mutations: A Multicenter Retrospective Cohort Study in South Korea | To identify potential candidates for adjuvant osimertinib, it is crucial to understand the rates and identify risk factors of recurrence. In stages I-III EGFR-mutated adenocarcinoma, the postoperative recurrence rate is 39.1%. Seven independent risk factors for recurrence have been identified: age >= 65 years, body mass index = 2.3 cm, N1 involvement, N2 involvement, predominantly micropapillary or solid pattern, and the presence of visceral pleural invasion. Introduction: Despite curative surgery for lung cancer, 30% to 55% of patients experience recurrence or death, which highlights the importance of adjuvant treatment. Adjuvant osimertinib therapy effectively prolongs disease-free and overall survival in patients with lung cancer harboring common epidermal growth factor receptor (EGFR) mutations. To identify potential candidates for adjuvant osimertinib, it is crucial to understand the rates and identify risk factors of recurrence. Methods: This multicenter, retrospective cohort study was conducted in the Republic of Korea and enrolled patients who, between 2010 and 2017, underwent resection of stages I-III adenocarcinomas, with common EGFR mutations. The primary outcomes comprised the rate and risk factors of postoperative recurrence. Results: Among the 759 participants, the overall recurrence rate and median recurrence-free survival were 39.1% and 59.8 (interquartile range [IQR], 26.3-84.2) months, respectively, during a median follow-up of 73.0 (IQR, 55.4-95.0) months. The recurrence rates for stages IA, IB, IIA, IIB, IIIA, and IIIB were 14.7%, 45.5%, 53.8%, 72.5%, 80.3%, and 93.3%, respectively. Multivariate analysis revealed that age >= 65 years, body mass index = 2.3 cm, N1 involvement, N2 involvement, predominantly micropapillary or solid pattern, and the presence of visceral pleural invasion were independently associated with recurrence. Conclusion: This multicenter cohort study demonstrated that stages I-III EGFR-mutated adenocarcinoma has a postoperative recurrence rate of 39.1%, and identified 7 independent risk factors for recurrence. | Ahn, June Hong; Choi, Sun Ha; Park, Sun Hyo; Kim, Insu; Park, Jin Han; Kim, Ji Yeon; Kim, Tae Hoon; Lee, Taehoon; Cho, Hyun Kyu; Jeong, Jong Hwan; Yang, Jung Wook; Park, Ji Eun; Kim, Tae Hun; Lee, Hyun-Kyung; Lee, Ho Young; Jung, Ho Jin; Kim, Jinmi; Son, Jungmin; Eom, Jung Seop | Yeungnam Univ, Med Ctr, Div Pulmonol & Allergy, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Div Pulmonol & Allergy, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Lung Canc Ctr, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Div Pulm Med, Daegu, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Coll Med, Dept Pathol, Busan, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Chang Won, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Chang Won, South Korea; Univ Ulsan, Ulsan Univ Hosp, Div Resp & Crit Care Med, Dept Internal Med,Coll Med, Ulsan, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Div Pulm & Crit Care Med,Dept Med, Chang Won, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Div Pulmonol & Allergy, Dept Internal Med,Sch Med, Jinju, South Korea; Coll Med, Jinju, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Busan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Pathol, Busan, South Korea; Pusan Natl Univ Hosp, Dept Biostat, Clin Trial Ctr, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, 179 Gudeok Ro, Busan 49241, South Korea | Ahn, June/AAB-3093-2019 | ejspulm@pusan.ac.kr; | CLINICAL LUNG CANCER | CLIN LUNG CANCER | 1525-7304 | 1938-0690 | 26 | 4 | SCIE | ONCOLOGY | 2024 | 3.3 | 37.6 | 0 | Disease recurrence; Epidermal growth factor receptor mutation; Lung adenocarcinoma; Surgery; Tyrosine kinase inhibitors | FACTOR RECEPTOR MUTATION; LUNG | English | 2025 | 2025-06 | 10.1016/j.clc.2025.02.016 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Poor Prognosis of Pneumococcal Co-Infection in Hospitalized Patients with COVID-19: A Propensity Score-Matched Analysis | The impact of Streptococcus pneumoniae coinfection on coronavirus disease 2019 (COVID-19) prognosis remains uncertain. We conducted a retrospective analysis of patients hospitalized with COVID-19 who underwent a pneumococcal urinary antigen (PUA) test to assess its clinical utility. Results showed that PUA-positive patients required more oxygen support, high-flow nasal cannula, and dexamethasone compared to PUA-negative patients. Furthermore, the significantly higher incidence of a National Early Warning Score >= 5 in the PUA-positive group (P<0.001) suggests that a positive PUA test is associated with a severe disease course. However, no significant difference in mortality was observed between the two groups, and antibiotics were used in almost all patients (96.2%). While the PUA test may help guide antibiotic use in COVID-19 patients, its interpretation should be approached with caution. | Hwang, Soyoon; Nam, Eunkyung; Kim, Shin-Woo; Chang, Hyun-Ha; Kim, Yoonjung; Bae, Sohyun; Lee, Nan Young; Kim, Yu Kyung; Kim, Ji Sun; Park, Han Wook; Bae, Joon Gyu; Jeong, Juhwan; Kwon, Ki Tae | Kyungpook Natl Univ, Sch Med, Dept Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Internal Med, Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Med Informat, Daegu, South Korea | Hwang, Soyoon/HHM-5762-2022 | 57203160675; 58121908200; 8710731500; 7407521688; 59510682700; 57219699506; 57209204358; 59840796100; 58147425600; 58257439500; 59735279500; 58981143700; 9733850500 | ktkwon@knu.ac.kr; | INFECTION AND CHEMOTHERAPY | INFECT CHEMOTHER | 2093-2340 | 2092-6448 | 57 | 1 | ESCI | INFECTIOUS DISEASES | 2024 | 2.9 | 37.6 | 0 | 2025-05-07 | 0 | 0 | Coronavirus Disease 2019; Streptococcus pneumoniae; Co-infection; Antibiotics | PNEUMONIA; ANTIGEN | Antibiotics; Co-infection; Coronavirus Disease 2019; Streptococcus pneumoniae | antibiotic agent; bacterial antigen; C reactive protein; dexamethasone; remdesivir; adult; aged; ambient air; antibiotic therapy; Article; artificial ventilation; breathing rate; clinical outcome; cohort analysis; coinfection; coronavirus disease 2019; disease course; disease severity; female; high flow nasal cannula therapy; hospital patient; hospitalization; human; immunofluorescence assay; intensive care unit; lung infiltrate; major clinical study; male; medical record review; middle aged; mortality rate; National Early Warning Score; oxygen saturation; oxygen therapy; pneumococcal infection; prognosis; propensity score; retrospective study; Streptococcus pneumoniae; very elderly | English | 2025 | 2025-03 | 10.3947/ic.2024.0130 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Targeting the Glucose-Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth | Head and neck squamous cell carcinoma (HNSCC) remains a clinically challenging malignancy with limited targeted therapy options and poor patient outcomes. Thus, identifying unique dependencies, including HNSCC-specific metabolic reprogramming, is imperative for improving treatment strategies for this disease. In this study, we show that HNSCC relies on elevated glucose transporter 1 (GLUT1)-mediated glucose uptake to support redox homeostasis and tumor growth. Analyses of GLUT1 expression data in tumors and cancer cell lines reveal significant upregulation of GLUT1 in HNSCC relative to both normal tissue and other cancer subtypes and that high GLUT1 expression correlates with poorer clinical outcomes. Using a basal epithelial layer-specific GLUT1-knockout mouse model, we demonstrate that GLUT1 ablation in HNSCC cells of origin markedly attenuates tumor initiation and progression, implicating the necessity of GLUT1 in HNSCC tumorigenesis. Building on this observation, combining pharmacologic inhibition of GLUT1 with pro-oxidants such as vitamin C and auranofin induces potent cytotoxicity in vitro and in vivo, partly by precipitating oxidative stress. We further observe that insulin signaling is required to sustain glucose uptake and redox homeostasis, as insulin receptor knockdown decreases proliferation and increases reactive oxygen species levels. Together, these results suggest that although GLUT1 overexpression is a key driver of glucose uptake, insulin signaling also contributes to the metabolic and oncogenic pathways underlying HNSCC progression. Consequently, strategies that co-target GLUT1 and insulin signaling to restrict glucose flux may synergize with pro-oxidant therapies, offering a promising therapeutic avenue for HNSCC.Significance: Enhanced GLUT1 expression and oncogenic insulin signaling drive elevated glucose uptake in HNSCC, which contribute to the maintenance of redox homeostasis and tumor growth. Disrupting both glucose uptake and redox balance may offer a promising therapeutic approach. | Mazambani, Simbarashe; Park, Seong-Ho; Choe, Joshua H.; Nguyen, An H.; Lee, Bok-Soon; Jeong, Ji Yun; Lee, Shin Yup; Kim, Chul-Ho; Park, Yea-In; Padilla, Joselyn; Lee, Jiyoung; Thotala, Dinesh; Oh, Tae Gyu; Singh, Pankaj K.; Hur, Hoon; Hur, Junho K.; Kim, Jung-whan; Kim, Tae Hoon | Univ Texas Dallas, Dept Biol Sci, Richardson, TX 75083 USA; Univ Oklahoma, Stephenson Canc Ctr, Coll Med, Dept Oncol Sci, Oklahoma City, OK USA; Hanyang Univ, Grad Sch, Dept Med, Seoul, South Korea; Harvard Med Sch, Div Med Sci, Boston, MA USA; Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA; Ajou Univ, Sch Med, Dept Otolaryngol, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; George Washington Univ, Dept Biochem & Mol Med, Sch Med & Hlth Sci, GW Canc Ctr, Washington, DC 20052 USA; Univ Oklahoma, Hlth Sci Ctr, Dept Radiat Oncol, Coll Med, Oklahoma City, OK USA; Ajou Univ, Sch Med, Dept Surg, Suwon, South Korea; Ajou Univ, Canc Biol Grad Program, Grad Sch Med, Suwon, South Korea; Hanyang Univ, Coll Med, Dept Genet, Seoul, South Korea; Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul, South Korea; Med Univ South Carolina, Dept Comparat Med, Charleston, SC 29425 USA | Hur, Junho/ADK-0757-2022; Choe, Joshua/AAH-8364-2020; 허, 훈/IWU-5877-2023 | 57208741527; 59953100800; 57194418652; 59953100900; 37081300600; 57205472984; 59899329100; 59953112500; 57215129611; 57222729145; 57206732420; 15752115100; 57205684733; 26323775900; 35319985500; 35740323500; 7601367197; 57201467658 | kimjung@musc.edu; genome@utdallas.edu; | CANCER RESEARCH COMMUNICATIONS | CANCER RES COMMUN | 2767-9764 | 5 | 6 | ESCI | ONCOLOGY | 2024 | 3.3 | 37.6 | 0 | 0 | RISK; CHEMOTHERAPY; PROOXIDANT; TXNIP | Animals; Cell Line, Tumor; Cell Proliferation; Glucose; Glucose Transporter Type 1; Head and Neck Neoplasms; Humans; Insulin; Mice; Mice, Knockout; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; glucose; glucose transporter 1; insulin; reactive oxygen metabolite; SLC2A1 protein, human; animal; cell proliferation; drug effect; drug therapy; genetics; head and neck squamous cell carcinoma; head and neck tumor; human; knockout mouse; metabolism; mouse; oxidative stress; pathology; signal transduction; tumor cell line | English | 2025 | 2025-06 | 10.1158/2767-9764.crc-23-0506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Effects of Nb doping on the thermoelectric performance of CuI doped n-type Bi2Te3 | The thermoelectric (TE) properties of Nb-doped (CuI)(0.003)Bi2-xNbxTe2.7Se0.3 compounds (x = 0, 0.005, 0.01 and 0.03), were investigated at temperatures ranging from 300 to 600 K. Among the compounds studied, the lightly substituted (CuI)(0.003)Bi1.995Nb0.005Te2.7Se0.3 compound exhibited the best TE performance due to the improvement in its electrical conductivity and its relatively unchanged Seebeck coefficient due to Nb doping. Its figure of merit, ZT, was greater than the undoped (CuI)(0.003)Bi2Te2.7Se0.3 compound for the temperature range investigated. In particular, the ZT of (CuI)(0.003)Bi1.995Nb0.005Te2.7Se0.3 reached a value of 0.65 at 448 K in this study. | Marekwa, Innocent Thato; Kihoi, Samuel Kimani; Kahiu, Joseph Ngugi; Kim, Hyunji; Shin, Dong Hyun; Lee, Ho Seong | Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Mat Sci & Met Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Automot Parts & Mat, 80 Daehak Ro, Daegu 41566, South Korea | Kihoi, Samuel Kimani/IUM-8515-2023 | 59538009100; 57208396874; 57222096169; 57208408040; 59148228400; 55706810400 | hs.lee@knu.ac.kr; | JOURNAL OF PHYSICS D-APPLIED PHYSICS | J PHYS D APPL PHYS | 0022-3727 | 1361-6463 | 58 | 2 | SCIE | PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 0 | 2025-05-07 | 0 | 0 | thermoelectric; bismuth telluride; Nb doping; electrical transport; figure of merit | LATTICE THERMAL-CONDUCTIVITY; BISMUTH-TELLURIDE; ELECTRICAL-PROPERTIES; DEFECT CHEMISTRY; ALLOYS; ENHANCEMENT; BI2TE2.7SE0.3; SEMICONDUCTOR; TRANSPORT; ROLES | bismuth telluride; electrical transport; figure of merit; Nb doping; thermoelectric | Bismuth compounds; Germanium compounds; Molybdenum compounds; Selenium compounds; Semiconductor doping; Surface discharges; Tantalum compounds; Tellurium compounds; Thermoelectric equipment; Thermoelectricity; Bismuth telluride; Electrical conductivity; Electrical transport; Figure of merit; Nb doped; Nb doping; Seebeck; Thermoelectric; Thermoelectric performance; Thermoelectric properties; Niobium compounds | English | 2025 | 2025-01-13 | 10.1088/1361-6463/ad809e | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sigmoid Probabilistic Bits Using SiOx Threshold Switching Devices for Probabilistic Computing | We present probabilistic bits(p-bits)implemented using a simple and fabrication-friendly Ti/SiOx/Ti stack for probabilistic computing. Sputter-deposited thin SiOx films (<10 nm) exhibit threshold switching (TS) behavior under dc characterization, producing continuous output voltage (Vout) oscillations in response to a given input voltage (Vin) pulse. Whena chemically reactive Ti scavenging layer is introduced, nonuniform TS properties are observed, resulting in switching voltage (or resistance) variability and unexpected oscillation failures. Consequently, Voutoscillations begin to be detected in the form of random spikes, emulatingthe probability of representing data as "1" (P1). Notably,we demonstrate that when the SiOx layer is sandwiched between Ti scavengers at both interfaces, the value ofP1can be controlled between 0 and 1 in an inverselyproportional relationship toVin. This sigmoidP1curvederived from Ti/SiOx/Ti p-bits plays a crucial role inexecuting simulated annealing (SA) algorithms. Thiscapability is validated through MATLAB simulations, where the approach is applied to solve vehicle routing problems(VRPs) by identifying optimal solutions | Choi, Hyeonsik; Kim, Jihyun; Moon, Jaehyun; Kang, Seung-Youl; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Elect & Telecommun Res Inst, Daejeon 34129, South Korea | Kang, Seung-Youl/JDD-8544-2023 | 58835686900; 59361845100; 8834503900; 7405686721; 53985749100 | jiyong.woo@knu.ac.kr; | IEEE TRANSACTIONS ON ELECTRON DEVICES | IEEE T ELECTRON DEV | 0018-9383 | 1557-9646 | 72 | 4 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;PHYSICS, APPLIED | 2024 | 3.2 | 37.7 | 0 | 2025-05-07 | 0 | 0 | Oscillators; Switches; Probabilistic logic; Temperature measurement; Resistance; Films; Probabilistic computing; Threshold voltage; Sputtering; Magnetic tunneling; Probabilistic bits; probabilistic computing; SiOx; threshold switching (TS); voltage oscillation | Probabilistic bits; probabilistic computing; SiOA; threshold switching (TS); voltage oscillation | Health risks; Probabilistic bit; Probabilistic computing; Probabilistics; Sigmoids; Simple++; SiO x; Switching devices; Threshold switching; Voltage oscillation; Simulated annealing | English | 2025 | 2025-04 | 10.1109/ted.2025.3540029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Characterization of a Tl2LaCl5:Ce Crystal Coupled With a Silicon Photomultiplier for a Compact Single-Photon Emission Computed Tomography System | The novel Tl2LaCl5:Ce (TLC) crystal scintillator has a high density and effective Z number. Hence, a single-photon emission computed tomography (SPECT) detector equipped with the scintillator has excellent X-ray and gamma -ray detection efficiency and a high light yield (LY). The feasibility of utilizing the TLC crystal coupled with a silicon photomultiplier (SiPM) was investigated for a compact SPECT detector. The TLC crystal (& Oslash; 8x2 mm) coupled with a one-channel SiPM ( 6.07x6.07 mm(2)) was used. Electrical characteristics of the SiPM were used for optimizing the operating voltage and dynamic range. The gamma -rays' energy spectra of (133) Ba, Am-241, and (152) Eu were obtained. The SiPM outputs were digitized utilizing a data acquisition (DAQ) system. The breakdown voltage of the SiPM was measured to be 24.8 V. The operating voltage was fixed as 29.8 V by comparing energy resolutions for different operating voltages under 81-keV gamma -ray excitation from a Ba-133 radioactive source. The linearity of the SiPM was measured to be within 3.7% for up to 8500 incident photons. Owing to the high LY of the TLC crystal and the dynamic range of SiPM, the best energy resolution of the TLC crystal was achieved to be 8.7% full-width-half-maximum at 121.7-keV gamma -ray at the voltage of 29.8 V. The TLC crystal coupled with SiPM is expected to be utilized for the development of compact SPECT detectors. It can replace conventional photomultiplier detectors and attain a good image quality, comparable to that of a solid-state detector in the SPECT system. | Bang, I. H.; Park, H. W.; Khan, A.; Jegal, J.; Kim, H. J. | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea; Najran Univ, Dept Phys, Najran 11001, Saudi Arabia; Najran Univ, Promising Ctr Sensors & Elect Devices PCSED, Najran 11001, Saudi Arabia; Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul 03080, South Korea; Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul 03080, South Korea | Khan, Arshad/ABB-1566-2021 | 59751570700; 58950744700; 56017063700; 57192238874; 58483690400 | tb01148@gmail.com; hongjoo@knu.ac.kr; | IEEE TRANSACTIONS ON NUCLEAR SCIENCE | IEEE T NUCL SCI | 0018-9499 | 1558-1578 | 72 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 1.9 | 37.8 | 0 | 2025-05-07 | 0 | 0 | Crystals; Scintillators; Single photon emission computed tomography; Photonics; Energy resolution; Detectors; Voltage measurement; Microcell networks; Photomultipliers; Energy measurement; Silicon photomultiplier (SiPM); single-photon emission computed tomography (SPECT) system; Tl2LaCl5:Ce (TLC) scintillator | PET; PERFORMANCE; DETECTOR; RAY; SCINTILLATORS | Silicon photomultiplier (SiPM); single-photon emission computed tomography (SPECT) system; Tl<sub>₂</sub>LaCl<sub>₅</sub>:Ce (TLC) scintillator | Atomic emission spectroscopy; Cerenkov counters; Cerium oxide; Gamma ray production; Gamma ray spectrometers; Lanthanum alloys; Photons; Remote sensing; Scintillation; Scintillation counters; Silicon detectors; Silicon wafers; Single photon emission computed tomography; Solid-state sensors; X ray detectors; Dynamic range; Emission Computed Tomography; High lights; Light yield; Operating voltage; Silicon photo multipliers (SiPM); Single photon emission; Single-photon emission computed tomography system; Tl2lacl5:ce scintillator; Tomography system; Particle beams | English | 2025 | 2025-05 | 10.1109/tns.2025.3562678 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Luminescence and scintillation properties of NaI:In crystal | Single crystal of NaI activated with 0.02, 0.05, 0.1, and 0.5 mole% indium (In) has been grown with a two-zone vertical Bridgman furnace. The luminescence measurement of the crystals is carried out under the excitation of X-rays and photoluminescence (PL). Under X-ray excitation, the emission has broad bands peaking at 450 and 535 nm. The maximum radioluminescence of the crystal is obtained for NaI:0.1mol%In. The pulse height spectra of the crystals are measured under 662 keV γ-rays excitation from a Cs-137 source. The absolute light yields of the crystals are calculated by comparing the 662 keV γ-rays photopeak with that measured for reference CsI:Tl and the indium-doped NaI crystals. The maximum light yield of ~ 42,000 photons/MeV is found for NaI:0.5mol%In. © 2025 IEEE. | Karki, Sujita; Pandey, Indra Raj; Khan, Arshad; Vuong, Phan Quoc; Lee, Moo Hyun; Kim, Yeong Duk; Kim, Hong Joo | Kyungpook National University, Department of Physics, Daegu, South Korea, Northwestern University, Department of Chemistry, Evanston, IL, United States; Northwestern University, Department of Chemistry, Evanston, IL, United States, Argonne National Laboratory, Material Science Division, Lemont, IL, United States; Najran University, Faculty of Arts and Science, Department of Physics, Najran, Saudi Arabia, Najran University, Advanced Materials and Nano-Research Centre (AMNRC), Najran, Saudi Arabia; Kyungpook National University, Center for High Energy Physics, Daegu, South Korea; Institute for Basic Science (IBS), Center for Underground Physics, Daejeon, South Korea, University of Science and Technology (UST), IBS School, Daejeon, South Korea; Kyungpook National University, Center for High Energy Physics, Daegu, South Korea, Institute for Basic Science (IBS), Center for Underground Physics, Daejeon, South Korea, University of Science and Technology (UST), IBS School, Daejeon, South Korea; Kyungpook National University, Center for High Energy Physics, Daegu, South Korea | 57188979693; 57188976474; 56017063700; 57207618553; 57198252980; 7410207253; 58483690400 | IEEE Transactions on Nuclear Science | IEEE T NUCL SCI | 0018-9499 | 1558-1578 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 1.9 | 37.8 | 0 | 2025-05-07 | 1 | absolute light yield; Bridgeman furnace; luminescence spectrum; pulse height spectra; Single Crystal | Atomic emission spectroscopy; Cesium alloys; Cesium iodide; Gamma rays; Luminescence of solids; Photoluminescence; Scintillation; Scintillation counters; Absolute light yield; Bridgeman furnace; Bridgman furnace; Luminescence measurements; Luminescence properties; Luminescence spectrum; Measurements of; Pulse height spectrum; Scintillation properties; X-ray excitation; Single crystals | English | Article in press | 2025 | 10.1109/tns.2025.3548085 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Optimization of Scintillation Light Collection Efficiency in BGO Crystals with Surface Diffusion for Enhanced Sensitivity in the KAPAE | The Kyungpook National University (KNU) Advanced Positronium Annihilation Experiment (KAPAE) aims to search for rare decays of positronium. The Phase I detector of KAPAE, equipped with Bismuth Germanate (Bi4Ge3O12, BGO) scintillation crystals with a polished surface, was designed to observe rare visible decays. The BGO scintillation crystals were chosen for their high gamma detection efficiency, high density, and high effective atomic number, making them suitable for gamma-ray detection in various applications, including medical imaging and high-energy physics experiments. However, due to its high refractive index of 2.15, BGO experiences considerable internal light trapping, which significantly reduces the efficiency of scintillation light collection. The Phase II detector focuses on detecting invisible decays of positronium by improving light collection efficiency and energy resolution while minimizing dead areas using surface-diffused BGO crystals. This paper investigates the light collection efficiency of 3 × 3 × 15 cm3 surface-diffused BGO crystals, demonstrating an approximately 22% higher light yield compared to polished surfaces. This improvement is confirmed by Monte Carlo simulations using the Geant4 toolkit, which predict similar enhancements in light collection efficiency. The energy resolution is improved from an average of 12% to 10.8% with the diffused BGO crystals at 662 keV. These results enhance the sensitivity of the KAPAE Phase II detector to invisible decays of positronium. These improvements in light collection efficiency and energy resolution of surfacediffused BGO crystals make them suitable materials for broader applications in experiments that require precise gamma energy measurement. In this paper, we present the optimization of the KAPAE detector, providing insights for the design and enhancement of scintillation detector performance in particle physics and other high-energy applications. © 1963-2012 IEEE. | Jeong, D.W.; Choi, E.; Cho, J.Y.; Luan, Nguyen Thanh; Park, H.; Park, H.W.; Shlegel, Vladimir; Kim, H.J. | Kyungpook National University, Department of Physics, Daegu, South Korea; Kyungpook National University, Department of Physics, Daegu, South Korea; Kyungpook National University, Department of Physics, Daegu, South Korea; Kyungpook National University, Department of Physics, Daegu, South Korea; Kyungpook National University, Department of Physics, Daegu, South Korea; Korea Research Institute of Standards and Science, (KRISS), South Korea; Siberian Branch of Russian Academy of Sciences, Nikolaev Institute of Inorganic Chemistry, Novosibirsk, 630090, Russian Federation; Kyungpook National University, Department of Physics, Daegu, South Korea | 57221047608; 59152694800; 57204422573; 57210576969; 58642658300; 58950744700; 6602324736; 59051568100 | hongjoo@knu.ac.kr; | IEEE Transactions on Nuclear Science | IEEE T NUCL SCI | 0018-9499 | 1558-1578 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NUCLEAR SCIENCE & TECHNOLOGY | 2024 | 1.9 | 37.8 | 0 | 2025-05-07 | 0 | BGO; Diffuse; KAPAE; Light collection; Scintillator | Bismuth alloys; Germanium compounds; Laser beams; Particle detectors; Photons; Positron annihilation; (KNU) advanced positronia annihilation experiment; Bi4ge3O12; Diffuse; Energy resolutions; Light collection; Light collection efficiency; Optimisations; Polished surfaces; Scintillation crystals; Scintillation light; Scintillation counters | English | Article in press | 2025 | 10.1109/tns.2025.3552904 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Comparative analysis of the lumboperitoneal shunt versus ventriculoperitoneal shunt for leptomeningeal metastasis-associated hydrocephalus in non-small cell lung cancer | Purpose Leptomeningeal metastasis (LM)-associated hydrocephalus is a rare but severe complication of non-small cell lung cancer (NSCLC). The spread of malignant cells to the leptomeninges obstructs cerebrospinal fluid flow and increases intracranial pressure (ICP). This study compared the outcomes of lumboperitoneal (LP) and ventriculoperitoneal (VP) shunt surgeries in managing LM-associated hydrocephalus, focusing on symptom-free periods (SFPs) and overall survival (OS). Methods A retrospective analysis was conducted on 43 NSCLC patients with LM-associated hydrocephalus who underwent shunt surgery between 2017 and 2024. Patients were classified into LP (n = 23) and VP (n = 20) groups. Clinical characteristics, surgical outcomes, and survival rates were analyzed using Kaplan-Meier survival and Cox regression analyses. Karnofsky performance status (KPS), increased intracranial pressure (IICP) symptoms, and postoperative epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment were evaluated for prognostic significance. Results No significant difference was observed between VP and LP shunt surgeries regarding SFP (VP: 5.02 +/- 1.29 months, LP: 7.50 +/- 2.86 months, p = 0.906) or OS (VP: 8.43 +/- 1.89 months, LP: 9.62 +/- 3.20 months, p = 0.820). High preoperative KPS, absence of ICP symptoms, and postoperative EGFR-TKI treatment were significantly associated with improved SFP and OS (p < 0.05). LP shunt surgery had shorter anesthesia and fewer complications compared to VP shunt surgery, representing a viable option for patients unsuitable for general anesthesia. Conclusion LP and VP shunt surgeries are equally effective for patients with LM-associated hydrocephalus in NSCLC. LP shunt surgery under local anesthesia could be recommended for its safety and patient acceptability. Favorable prognostic factors, including high KPS, absence of ICP, and postoperative EGFR-TKI treatment, should guide individualized treatment strategies to enhance patient outcomes and quality of life. | Kim, Minjoon; Lee, Chaejin; Yoon, Sang-Youl; Park, Seong-Hyun; Hwang, Jeong-Hyun; Kang, Kyunghun; Park, Eunhee; Choi, Sunha; Lee, Shin Yup; Yoo, Seung Soo; Chae, Yee Soo; Park, Ki-Su | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, 101 Dongin Dong 2 Ga, Daegu 700422, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Pulmonol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Hematooncol, Daegu, South Korea | 59700132600; 57211989339; 57195615457; 21734563200; 7403896906; 55365592200; 56107216400; 57199723585; 49863712700; 56479781600; 57190793908; 55932363100 | kiss798@gmail.com; | ACTA NEUROCHIRURGICA | ACTA NEUROCHIR | 0001-6268 | 0942-0940 | 167 | 1 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 1.9 | 38.0 | 0 | 2025-05-07 | 1 | 1 | Non-small-cell lung; Carcinoma; Meningeal carcinomatosis; Hydrocephalus; Ventriculoperitoneal shunt | DIAGNOSIS; CHALLENGES | Carcinoma; Hydrocephalus; Meningeal carcinomatosis; Non-small-cell lung; Ventriculoperitoneal shunt | Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cerebrospinal Fluid Shunts; Female; Humans; Hydrocephalus; Lung Neoplasms; Male; Meningeal Neoplasms; Middle Aged; Retrospective Studies; Treatment Outcome; Ventriculoperitoneal Shunt; epidermal growth factor receptor kinase inhibitor; adult; Article; cancer patient; cancer survival; clinical article; clinical outcome; controlled study; female; general anesthesia; human; hydrocephalus; intermethod comparison; intracranial hypertension; Karnofsky Performance Status; male; meningeal metastasis; middle aged; non small cell lung cancer; overall survival; postoperative complication; preoperative evaluation; retrospective study; subdural hematoma; survival rate; wound dehiscence; aged; brain ventricle peritoneum shunt; cerebrospinal fluid drainage system; comparative study; etiology; hydrocephalus; lung tumor; meningeal tumor; non small cell lung cancer; pathology; procedures; surgery; treatment outcome | English | 2025 | 2025-03-19 | 10.1007/s00701-025-06490-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study | BackgroundHypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia can lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims to investigate a patient with rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed chronic hypokalemia owing to prolonged diarrhea, leading to severe AKI with anuria.Case presentationA 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. Despite having no prior kidney disease, his serum creatinine increased to 4.8 mg/dL, and potassium dropped to 2.2 mmol/L. Initial treatment included hemodialysis for anuric AKI with metabolic acidosis. A kidney biopsy revealed renal tubular vacuolization and With-no-lysine kinase (WNK) bodies in the distal tubules, which are characteristic of hypokalemic nephropathy. Potassium replacement therapy led to a gradual recovery of potassium levels and kidney function.ConclusionThis case highlights the importance of timely diagnosis and management of hypokalemic nephropathy through kidney biopsy. | Lee, Seong-Wook; Han, Man-Hoon; Kim, Mee-Seon; Kim, Yong-Jin; Jeon, You Hyun; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Lim, Jeong-Hoon | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol,Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Dent, Dept Pathol, Daegu, South Korea | Park, Sun-Hee/LMN-0033-2024; Cho, Jang-hee/ABD-3534-2020; Lim, Jeong-Hoon/ABE-6003-2020 | 58844486200; 57194067936; 59510682600; 56150365500; 57820096000; 57196396467; 7501393222; 7403536291; 7501831741; 8558530700; 55633533600; 55360244300 | jh-lim@knu.ac.kr; | BMC NEPHROLOGY | BMC NEPHROL | 1471-2369 | 26 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 0 | 2025-05-07 | 0 | 0 | Acute kidney injury; Anuria; Hypokalemic nephropathy; Kidney biopsy; Vacuolization; WNK bodies | NEPHROPATHY; POTASSIUM; RAT | Acute kidney injury; Anuria; Hypokalemic nephropathy; Kidney biopsy; Vacuolization; WNK bodies | Acute Kidney Injury; Anuria; Diarrhea; Humans; Hypokalemia; Male; Middle Aged; Potassium; Rectal Neoplasms; Renal Dialysis; antidiarrheal agent; bicarbonate; C reactive protein; calcium; chloride; creatinine; hemoglobin; neutrophil gelatinase associated lipocalin; potassium; protein serine threonine kinase; sodium; spironolactone; unclassified drug; valsartan; with no lysine kinase; potassium; acute kidney failure; adult; anuria; Article; blood pressure; body mass; body temperature; case report; chemoradiotherapy; chronic diarrhea; clinical article; computer assisted tomography; concurrent chemoradiotherapy; creatinine blood level; diarrhea; endoscopic biopsy; follow up; glomerulonephritis; hematuria; hemodialysis; human; hypertension; hypokalemia; ileostomy; immunofluorescence microscopy; kidney biopsy; kidney distal tubule; kidney function; leg muscle weakness; leukocyte count; male; metabolic acidosis; middle aged; muscle weakness; platelet count; protein creatinine ratio; proteinuria; rectum cancer; urea nitrogen blood level; urinalysis; urine volume; blood; complication; diarrhea; etiology; rectum tumor; therapy | English | 2025 | 2025-03-24 | 10.1186/s12882-025-03973-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | The renoprotective effects of tadalafil on ischemia–reperfusion injury during partial nephrectomy in an animal model | Background: Although 25 min is the reported safe partial nephrectomy time for warm ischemia, acute kidney injury occurs even with arterial ligation within 25 min, causing serious complications in patients with chronic renal disease. Various drugs have been studied but evidence of their effectiveness and safety is insufficient. This study investigated the renoprotective function of tadalafil. Methods: A rat model of partial nephrectomy was treated orally with tadalafil for 14 days before ischemic–reperfusion (IR) injury. Blood and kidney samples were collected for biochemical and molecular analyses 24 h after IR injury. The levels of serum blood urea nitrogen, creatinine, and urine kidney injury molecule-1 were analyzed, while kidney tissues were used for qPCR and histological analysis. Results: Although effects on blood urea nitrogen and creatine levels were not observed, tadalafil preserved renal function by suppressing the decrease of viable glomeruli, indicating it protected kidneys from IR injury-induced glomeruli loss. Tadalafil effectively reduced the expression of the oxidative stress markers, inducible NOS, endothelial NOS, and myeloperoxidase, and significantly suppressed the expression of inflammation-related genes like TNF-α, IL-1β, IL-6, CD4, and CD8. Conclusions: Tadalafil inhibits oxidative stress and inflammation, and protects from glomeruli loss during ischemic–reperfusion damage in a rat model of partial nephrectomy. Clinical trial number: Not applicable. © The Author(s) 2025. | Lee, Eun Hye; Yoo, Eun Sang; Yoon, Bo Hyun; Jeon, Minji; Kwon, Tae Gyun; Kim, Bum Soo; Ha, Yun-Sok; Han, Man-Hoon; Song, Phil Hyun; Chung, Jae-Wook | Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pathology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, Yeungnam University College of Medicine, Daegu, South Korea; Joint Institute of Regenerative Medicine, Kyungpook National University, Daegu, South Korea, Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea | 57189661699; 59788386600; 57218931150; 59026085100; 59682802000; 57202817150; 35487226400; 57194067936; 8644562400; 35204798500 | jeus119@hanmail.net; | BMC Nephrology | BMC NEPHROL | N/A | 1471-2369 | 26 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 2.4 | 38.0 | 0 | Ischemic–reperfusion injury; Partial nephrectomy; Tadalafil | English | Final | 2025 | 10.1186/s12882-025-04265-2 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses | Background/Objective: Highly pathogenic (HP) H5Nx and low-pathogenicity (LP) H9N2 avian influenza viruses (AIVs) pose global threats to the poultry industry and public health, highlighting the critical need for a dual-protective vaccine. Methods: In this study, we generated a model PR8-derived recombinant H5N2 vaccine strain with hemagglutinin (HA) and neuraminidase (NA) genes from clade 2.3.2.1c H5N1 and Y439-like H9N2 viruses, respectively. To enhance the immunogenicity of the recombinant H5N2 vaccine strain, N-glycans of the HA2 subunit, NA, and M2e were modified. Additionally, we replaced M2e with avian M2e to enhance the antigenic homogeneity of AIVs for better protection. We also replaced PR8 PB2 with 01310 PB2, which is the PB2 gene derived from an LP H9N2 avian influenza virus, to eliminate pathogenicity in mammals. The productivity of the model vaccine strain (rvH5N2-aM2e-vPB2) in embryonated chicken eggs (ECEs), its potential risk of mammalian infection, and the immunogenicity associated with different inactivation methods (formaldehyde (F/A) vs. binary ethyleneimine (BEI)) were evaluated. Results: The rvH5N2-aM2e-vPB2 strain demonstrated high productivity in ECEs and exhibited complete inhibition of replication in mammalian cells. Furthermore, compared with using F/A inactivation, inactivation using BEI significantly enhanced the immune response, particularly against NA. This enhancement resulted in increased virus neutralization titers, supporting its efficacy for dual protection against H5Nx and H9N2 avian influenza viruses. Furthermore, we demonstrated that M2e-specific immune responses, difficult to induce with inactivated vaccines, can be effectively elicited with live vaccines, suggesting a strategy to enhance M2e immunogenicity in whole influenza virus vaccines. Conclusions: Finally, the successful development of the model rH5N2 vaccine strain is described; this strain provides dual protection, has potential applicability in regions where avian influenza is endemic, and can be used to promote the development of versatile H5N2 recombinant vaccines for effective avian influenza control. | Song, Jin-Ha; Son, Seung-Eun; Kim, Ho-Won; An, Se-Hee; Lee, Chung-Young; Kwon, Hyuk-Joon; Choi, Kang-Seuk | Seoul Natl Univ, Coll Vet Med, Lab Avian Dis, Seoul 08826, South Korea; Anim & Plant Quarantine Agcy, Avian Influenza Res & Diagnost Div, Gimcheon 39660, South Korea; Kyungpook Natl Univ, Coll Med, Dept Microbiol, Daegu 41944, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Coll Vet Med, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Farm Anim Med, Lab Poultry Med, Seoul 88026, South Korea; Seoul Natl Univ, BK21 PLUS Vet Sci, Seoul 88026, South Korea; Seoul Natl Univ, Inst Green Bio Sci & Technol GBST, Farm Anim Clin Training & Res Ctr FACTRC, Pyeongchang 25354, South Korea; GeNiner Inc, Seoul 08826, South Korea | 57221101773; 57221094613; 58516482000; 57195539685; 57195422071; 57196596247; 35798047900 | sjh1243@snu.ac.kr; arbre04@snu.ac.kr; iamkhw52@snu.ac.kr; ashpri@korea.kr; cylee87@knu.ac.kr; kwonhj01@snu.ac.kr; kchoi0608@snu.ac.kr; | VACCINES | VACCINES-BASEL | 2076-393X | 13 | 1 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 3.4 | 38.2 | 0 | 2025-05-07 | 0 | 0 | dual protection; highly pathogenic avian influenza virus; binary ethylenimine inactivation; N-glycosylation; NA immunity | ANIMALS STRATEGY; MATRIX PROTEIN-2; A VIRUS; NEURAMINIDASE; HEMAGGLUTININ; GENERATION; INFECTIONS; DOMAIN; LENGTH | binary ethylenimine inactivation; dual protection; H9N2 avian influenza virus; highly pathogenic avian influenza virus; N-glycosylation; NA immunity | hemagglutinin; influenza vaccine; sialidase; animal cell; animal experiment; animal model; Article; blood sampling; cellular immunity; circular dichroism; controlled study; enzyme linked immunosorbent assay; female; glycosylation; hemagglutination inhibition test; humoral immunity; IC50; ID50 (median infectious dose); immunization; immunogenicity; influenza; influenza A; Influenza A virus (H5N2); MDCK cell line; mouse; nonhuman; polymerase chain reaction; real time polymerase chain reaction; vaccine immunogenicity; virus neutralization | English | 2025 | 2025-01 | 10.3390/vaccines13010022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Phylogeny and species delimitation of ciliates in the genus Spirostomum (class Heterotrichea) using single-cell transcriptomes | BackgroundCiliates are single-celled microbial eukaryotes that diverged from other eukaryotic lineages more than a billion years ago. The long evolutionary timespan of ciliates has led to enormous genetic and phenotypic changes, contributing significantly to their high level of diversity. Recent analyses based on molecular data have revealed numerous cases of cryptic species complexes in different ciliate lineages, demonstrating the need for a robust approach to delimit species boundaries and elucidate phylogenetic relationships. Species of the genus Spirostomum are difficult to identify due to the lack of distinctive morphological characters. Previous molecular studies have focused on only a few loci, namely the nuclear ribosomal RNA genes, alpha-tubulin, and mitochondrial CO1, suggesting the presence of several cryptic Spirostomum species. In this study, we increased taxon sampling and obtained single-cell transcriptomes of 25 Spirostomum specimens (representing six morphospecies) sampled from South Korea and the USA. We evaluated the utility of the transcriptomic data by constructing species trees using concatenation and coalescent-based methods. In addition, we used neighbor-net network analysis to visualize and quantify potential phylogenetic conflicts within the concatenated dataset. Furthermore, coalescent-based species delimitation was performed with transcriptomic data to define the species boundaries within the genus Spirostomum.ResultsPhylogenomic analysis of 37 Spirostomum specimens (25 newly generated transcriptomes and 12 from GenBank) and 265 protein-coding genes provides robust insight into the evolutionary relationships among Spirostomum species. Our results confirm that species with moniliform and compact macronucleus each form a distinct monophyletic lineage, with the compact macronucleus likely representing the ancestral state, while the moniliform macronucleus being a derived trait. Furthermore, our analyses suggest that ancestral polymorphism and rapid radiation may have shaped the genetic diversity and evolutionary history of Spirostomum, and the S. minus-like appearance represents the ancestral state of the species with a moniliform macronucleus. Therefore, the S. minus-like species share ancestral morphological traits and cannot be morphologically delimited. The multispecies coalescent (MSC) model suggests that two cryptic species from each of S. minus, S. ambiguum, S. subtilis, S. teres, and S. aff. minus represent distinct lineages within the genus Spirostomum. We also provide a workflow for reconstructing nuclear ribosomal RNA gene sequences from transcriptome sequences using a read mapping approach, and compare different mapping methods to reconstruct reliable contigs.ConclusionOur sampling of closely related Spirostomum populations and comprehensive single-cell RNA sequencing (scRNA-seq) data allowed us to reveal the hidden crypticity of species within the genus Spirostomum and to resolve and provide much stronger support than hitherto to the phylogeny of this model ciliate genus. | Shazib, Shahed Uddin Ahmed; Cote-L'Heureux, Auden; Ahsan, Ragib; Munoz-Gomez, Sergio A.; Lee, Junmo; Katz, Laura A.; Shin, Mann Kyoon | Univ Ulsan, Dept Biol Sci, Ulsan 44610, South Korea; Smith Coll, Dept Biol Sci, 44 Coll Lane, Northampton, MA 01063 USA; Univ Massachusetts Amherst, Program Organism & Evolutionary Biol, Amherst, MA 01003 USA; Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA; Purdue Univ, Ctr Plant Biol, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Dept Oceanog, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Inst Oceanog, Daegu 41566, South Korea | Munoz-Gomez, Sergio/HTN-8936-2023; SHAZIB, SHAHED UDDIN AHMED/AAT-2802-2021; Shin, Mann Kyoon/M-7043-2013; Katz, Laura/AAF-4802-2019 | 56043438700; 57769753300; 57513993000; 55973102900; 57217851052; 56241339200; 8942469600 | shahed30ahmed@gmail.com; lkatz@smith.edu; mkshin@ulsan.ac.kr; | BMC ECOLOGY AND EVOLUTION | BMC ECOL EVOL | 2730-7182 | 25 | 1 | SCIE | ECOLOGY;EVOLUTIONARY BIOLOGY;GENETICS & HEREDITY | 2024 | 2.6 | 38.2 | 0 | 2025-05-07 | 0 | 0 | Cryptic species; Multispecies coalescent (MSC); Read mapping; scRNA-seq; Species tree | MULTIPLE SEQUENCE ALIGNMENT; MOLECULAR PHYLOGENY; TREE ESTIMATION; CILIOPHORA; POSTCILIODESMATOPHORA; BIODIVERSITY; IDENTIFICATION; MORPHOLOGY; PROTISTA; GENES | Cryptic species; Multispecies coalescent (MSC); Read mapping; scRNA-seq; Species tree | Ciliophora; Phylogeny; Republic of Korea; Single-Cell Analysis; Transcriptome; South Korea; transcriptome; ancestry; ciliate; classification; coalescence; evolution; genetic analysis; mitochondrion; morphology; phylogeny; RNA; taxonomy; ciliate; classification; genetics; phylogeny; single cell analysis; South Korea | English | 2025 | 2025-02-27 | 10.1186/s12862-025-02353-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of Tegoprazan and Lansoprazole in Patients With Erosive Esophagitis up to 4 Weeks: A Multi-Center, Randomized, Double-Blind, Active-Comparator Phase 4 Trial | Background: The aims of this study were to confirm the non-inferiority of tegoprazan to lansoprazole up to week 4 in patients with erosive esophagitis (EE) and to evaluate its effectiveness in rapid mucosal healing and symptom relief at week 2. Methods: In this multi-center, randomized, double-blind, active-comparator non-inferiority trial, 218 patients with endoscopically confirmed EE (Los Angeles Classification Grades A-D) were randomly allocated to either the tegoprazan (50 mg) or lansoprazole (30 mg) group. The primary endpoint was the cumulative proportion of patients with healed EE up to week 4, as confirmed through endoscopy. The proportion of patients with healed EE at week 2 was also evaluated. Furthermore, CYP2C19 genotypes, symptoms, safety, and tolerability were assessed. Key Results: In the full-analysis set, 103 and 109 participants in the tegoprazan and lansoprazole groups, respectively, were analyzed. The cumulative healing rates up to week 4 were 95.2% (98/103) and 86.2% (94/109) (difference [95% confidence interval], 8.91 [1.22-16.59]; p < 0.0001 for non-inferiority and 0.0266 for superiority), while those at week 2 were 88.4% (91/103) and 82.6% (90/109) (5.78 [-3.66-15.22], p = 0.0005 for non-inferiority) for tegoprazan and lansoprazole, respectively. Tegoprazan showed consistent healing rates regardless of CYP2C19 genotypes. Conclusions and Inferences: Tegoprazan was superior to lansoprazole in the treatment of EE up to 4 weeks. Further studies are necessary to confirm these findings and clarify the superiority of tegoprazan, especially in the treatment of severe EE. | Shin, Cheol Min; Choi, Suck Chei; Cho, Jin Woong; Kim, Seung Young; Lee, Ok Jae; Kim, Do Hoon; Cho, Yu Kyung; Lee, Ju Yup; Lee, Sang Kil; Shin, Jeong Eun; Kim, Gwang Ha; Park, Seon-Young; Hong, Su Jin; Jung, Hye-Kyung; Lee, Sang Jin; Youn, Young Hoon; Jeon, Seong Woo; Sung, In Kyung; Park, Moo In; Lee, Oh Young | Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Wonkwang Univ, Sch Med, Dept Gastroenterol, Iksan, South Korea; Presbyterian Med Ctr, Dept Internal Med, Jeonju, South Korea; Korea Univ, Ansan Hosp, Dept Gastroenterol, Ansan, South Korea; Gyeongsang Natl Univ Hosp, Dept Internal Med, Jinju, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Hosp, Daegu, South Korea; Yonsei Univ, Severance Hosp, Dept Gastroenterol, Coll Med, Seoul, South Korea; Dankook Univ Hosp, Dept Gastroenterol, Cheonan, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Chonnam Natl Univ Hosp, Dept Gastroenterol, Gwangju, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Bucheon, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Internal Med, Kangnung, South Korea; Yonsei Univ, Coll Med, Gangnam Severance Hosp, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Gastroenterol, Daegu, South Korea; Konkuk Univ, Med Ctr, Dept Internal Med, Seoul, South Korea; Kosin Univ, Gospel Hosp, Gospel Hosp, Busan 602702, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea | Kim, Gwang Ha/ABF-3932-2021; Lee, In/J-9324-2013; Lee, Yoojin/AAB-9799-2022; Lee, Young/ABA-7224-2020; Jeon, Seongwoo/AAU-4618-2020 | 35338000300; 7408119608; 53163643000; 24766250100; 8569374900; 58750755200; 23491673100; 55891683700; 59722190100; 55239527500; 35214772400; 7501833800; 35285527200; 7403029723; 57193208376; 36924075100; 9733636500; 57226383709; 8666034000; 57252457600 | scm6md@gmail.com; medcsc@wku.ac.kr; | NEUROGASTROENTEROLOGY AND MOTILITY | NEUROGASTROENT MOTIL | 1350-1925 | 1365-2982 | 37 | 1 | SCIE | CLINICAL NEUROLOGY;GASTROENTEROLOGY & HEPATOLOGY;NEUROSCIENCES | 2024 | 2.9 | 38.4 | 0 | 2025-05-07 | 1 | 2 | erosive esophagitis; lansoprazole; potassium competitive acid blocker; proton pump inhibitor; tegoprazan | COMPETITIVE ACID BLOCKER; REFLUX ESOPHAGITIS; RISK-FACTORS; VONOPRAZAN; GASTROESOPHAGEAL; PREVALENCE; IMPEDANCE | erosive esophagitis; lansoprazole; potassium competitive acid blocker; proton pump inhibitor; tegoprazan | Adult; Aged; Cytochrome P-450 CYP2C19; Double-Blind Method; Esophagitis; Female; Humans; Lansoprazole; Male; Middle Aged; Proton Pump Inhibitors; Treatment Outcome; cytochrome P450 2C19; lansoprazole; tegoprazan; CYP2C19 protein, human; cytochrome P450 2C19; lansoprazole; proton pump inhibitor; adult; Article; controlled study; disease severity; double blind procedure; drug efficacy; drug safety; drug tolerability; endoscopy; esophagus mucosa; female; genotype; healing; healing rate; heartburn; human; major clinical study; male; middle aged; multicenter study; phase 4 clinical trial; pilot study; randomization; randomized controlled trial; reflux esophagitis; unspecified side effect; aged; clinical trial; comparative study; drug therapy; esophagitis; genetics; treatment outcome | English | 2025 | 2025-01 | 10.1111/nmo.14969 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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