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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Bacteria for Treatment: Microbiome in Bladder Cancer | The human body contains a variety of microbes. The distribution of microbes varies from organ to organ. Sequencing and bioinformatics techniques have revolutionized microbial research. Although previously considered to be sterile, the urinary bladder contains various microbes. Several studies have used urine and bladder tissues to reveal the microbiome of the urinary bladder. Lactic acid-producing bacteria, such as Bifidobacterium, Lactobacillus, and Lactococcus, are particularly beneficial for human health and are linked to bladder cancer. This review highlights the analysis protocols for microbiome research, the studies undertaken to date, and the microbes with therapeutic potential in bladder cancer. | Min, Kyungchan; Kim, Hyun Tae; Lee, Eun Hye; Park, Hansoo; Ha, Yun-Sok | Gwangju Inst Sci & Technol, Dept Biomed Sci & Engn, Gwangju 61005, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu 41944, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu 41404, South Korea | 57876746900; 55739531300; 57189661699; 56144951400; 35487226400 | minchance@gm.gist.ac.kr;urologistk@knu.ac.kr;eun90hye@gmail.com;hspark27@gist.ac.kr;yunsokha@gmail.com; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 0.74 | 2025-06-25 | 15 | 16 | microbiome; bladder cancer; Bifidobacterium; Lactobacillus; Lactococcus | CASEI STRAIN SHIROTA; BACILLUS-CALMETTE-GUERIN; BLOOD MONONUCLEAR-CELLS; LACTOBACILLUS-CASEI; BIFIDOBACTERIUM-INFANTIS; TRANSURETHRAL RESECTION; MYCOBACTERIUM-BOVIS; INTERFERON-GAMMA; DAIRY INTAKE; RISK | Bifidobacterium; bladder cancer; Lactobacillus; Lactococcus; microbiome | English | 2022 | 2022-08 | 10.3390/biomedicines10081783 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Combination of Glycinamide and Ascorbic Acid Synergistically Promotes Collagen Production and Wound Healing in Human Dermal Fibroblasts | The purpose of this study is to present a novel strategy to enhance collagen production in cells. To identify amino acid analogs with excellent collagen production-enhancing effects, human dermal fibroblasts (HDFs) were treated with 20 kinds of amidated amino acids and 20 kinds of free amino acids, individually at 1 mM. The results showed that glycinamide enhanced collagen production (secreted collagen level) most effectively. Glycine also enhanced collagen production to a lesser degree. However, other glycine derivatives, such as N-acetyl glycine, N-acetyl glycinamide, glycine methyl ester, glycine ethyl ester, and glycyl glycine, did not show such effects. Glycinamide increased type I and III collagen protein levels without affecting COL1A1 and COL3A1 mRNA levels, whereas transforming growth factor-1 beta (TGF-beta 1, 10 ng mL(-1)) increased both mRNA and protein levels of collagens. Ascorbic acid (AA, 1 mM) increased COL1A1 and COL3A1 mRNA and collagen I protein levels. Unlike TGF-beta 1, AA and glycinamide did not increase the protein level of oc-smooth muscle actin, a marker of differentiation of fibroblasts into myofibroblasts. The combination of AA and glycinamide synergistically enhanced collagen production and wound closure in HDFs to a level similar to that in cells treated with TGF-beta 1. AA derivatives, such as magnesium ascorbyl 3-phosphate (MAP), 3-O-ethyl ascorbic acid, ascorbyl 2-O-glucoside, and ascorbyl tetraisopalmitate, enhanced collagen production, and the mRNA and protein levels of collagens at 1 mM, and their effects were further enhanced when co-treated with glycinamide. Among AA derivatives, MAP had a similar effect to AA in enhancing wound closure, and its effect was further enhanced by glycinamide. Other AA derivatives had different effects on wound closure. This study provides a new strategy to enhance cell collagen production and wound healing using glycinamide in combination with AA. | Lee, Ji Eun; Boo, Yong Chool | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Mol Med, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 55689967800; 6602899130 | leeje0825@naver.com;ycboo@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 1.29 | 2025-06-25 | 13 | 13 | dermal fibroblasts; collagen production; glycinamide; glycine; ascorbic acid; wound healing | EXTRACELLULAR-MATRIX; MESSENGER-RNA; III COLLAGEN; I COLLAGEN; SKIN; EXPRESSION; GLUTAMINE; TETRAISOPALMITATE; MELANOGENESIS; BIOSYNTHESIS | ascorbic acid; collagen production; dermal fibroblasts; glycinamide; glycine; wound healing | English | 2022 | 2022-05 | 10.3390/biomedicines10051029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Diagnostic and Therapeutic Potential of Circulating-Free DNA and Cell-Free RNA in Cancer Management | Over time, molecular biology and genomics techniques have been developed to speed up the early diagnosis and clinical management of cancer. These therapies are often most effective when administered to the subset of malignancies harboring the target identified by molecular testing. Important advances in applying molecular testing involve circulating-free DNA (cf DN A)- and cellfree RNA (cfRNA)-based liquid biopsies for the diagnosis, prognosis, prediction, and treatment of cancer. Both cfDNA and cfRNA are sensitive and specific biomarkers for cancer detection, which have been clinically proven through multiple randomized and prospective trials. These help in cancer management based on the noninvasive evaluation of size, quantity, and point mutations, as well as copy number alterations at the tumor site. Moreover, personalized detection of ctDNA helps in adjuvant therapeutics and predicts the chances of recurrence of cancer and resistance to cancer therapy. Despite the controversial diagnostic values of cfDNA and cfRNA, many clinical trials have been completed, and the Food and Drug Administration has approved many multigene assays to detect genetic alterations in the cfDNA of cancer patients. In this review, we underpin the recent advances in the physiological roles of cfDNA and cfRNA, as well as their roles in cancer detection by highlighting recent clinical trials and their roles as prognostic and predictive markers in cancer management. | Hassan, Sadia; Shehzad, Adeeb; Khan, Shahid Ali; Miran, Waheed; Khan, Salman; Lee, Young-Sup | Natl Univ Sci & Technol NUST, Sch Mech & Mfg Engn SMME, Dept Biomed Engn & Sci, Islamabad 44000, Pakistan; Natl Univ Sci & Technol NUST, Sch Nat Sci SNS, Dept Chem, Islamabad 44000, Pakistan; Natl Univ Sci & Technol NUST, Dept Chem Engn, Sch Chem & Mat Engn, Islamabad 44000, Pakistan; Quaid I Azam Univ, Dept Pharm, Islamabad 44000, Pakistan; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea | Shehzad, Adeeb/HHN-4847-2022; Khan, Salman/F-4588-2016; Miran, Waheed/G-6671-2016; Khan, Shahid/AAL-6431-2021 | 57278726900; 36162526700; 56701452800; 57195984440; 54393307500; 36013628200 | adeeb.shehzad@smme.nust.edu.pk;yselee@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 0.78 | 2025-06-25 | 14 | 17 | liquid biopsy; cancer; anticancer therapy; diagnosis; cfRNA; cfDNA; biomarkers | MINIMAL RESIDUAL DISEASE; FREE NUCLEIC-ACIDS; LUNG-CANCER; TUMOR DNA; CLINICAL VALIDATION; COLORECTAL-CANCER; LIQUID BIOPSY; PLASMA; BIOMARKER; BLOOD | anticancer therapy; biomarkers; cancer; cfDNA; cfRNA; diagnosis; liquid biopsy | English | 2022 | 2022-08 | 10.3390/biomedicines10082047 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer's Disease | Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical consequences. Advanced research on the pathogenesis of AD has elucidated a mechanistic framework and revealed many therapeutic possibilities. Among the mechanisms, sphingolipids are mentioned as distinctive mediators to be associated with the pathology of AD. Reportedly, alteration in the metabolism of sphingolipids and their metabolites result in the dysfunction of mitochondria, autophagy, amyloid beta regulation, and neuronal homeostasis, which exacerbates AD progression. Considering the importance of sphingolipids, in this review, we discuss the role of ceramide, a bioactive sphingolipid metabolite, in the progression and pathogenesis of AD. Herein, we describe the ceramide synthesis pathway and its involvement in the dysregulation of homeostasis, which eventually leads to AD. Furthermore, this review references different therapeutics proposed to modulate the ceramide pathway to maintain ceramide levels and prevent the disease progression. | Chowdhury, Md Riad; Jin, Hee Kyung; Bae, Jae-sung | Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Lab Anim Med, Coll Vet Med, Daegu 41566, South Korea | Bae, Jae-sung/AAM-8663-2021; Chowdhury, Md. Riad/AAA-1410-2022; Kim, Young/T-8521-2019 | 57876552200; 8088145800; 35209510400 | hkjin@knu.ac.kr;jsbae@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 1.15 | 2025-06-25 | 29 | 26 | Alzheimer's disease; ceramide; amyloid beta; autophagy; mitochondrial dysfunction; senescence | NEUTRAL SPHINGOMYELINASE INHIBITOR; ACID SPHINGOMYELINASE; PLASMA CERAMIDES; SERINE PALMITOYLTRANSFERASE; INSULIN-RESISTANCE; SALVAGE PATHWAY; UP-REGULATION; AMYLOID-BETA; CELL-DEATH; AUTOPHAGY | Alzheimer’s disease; amyloid beta; autophagy; ceramide; mitochondrial dysfunction; senescence | English | 2022 | 2022-08 | 10.3390/biomedicines10081956 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Interleukin-4 Receptor Targeting Peptide Decorated Extracellular Vesicles as a Platform for In Vivo Drug Delivery to Thyroid Cancer | Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been demonstrated to deliver therapeutic drugs in preclinical studies. However, their use is limited, as they lack the ability to specifically deliver drugs to tumor tissues in vivo. In the present study, we propose the use of a targeting peptide, IL-4R-binding peptide (IL4RPep-1), to specifically deliver intravenously (i.v.) infused EVs to thyroid tumors. In vivo, a xenograft tumor model was treated with either the control peptide (NSSSVDK) or IL4RPep-1-Flamma; mice were fluorescently imaged (FLI) using an in vivo imaging system at 0-3 h post-treatment. EVs (labeled with DiD dye) were conjugated with IL4RPep-1 through a DOPE-NHS linker and administered to mice intravenously. FLI was performed 0-24 h post-injection, and the animals were sacrificed for further experiments. The morphology and size of EVs, the presence of EV markers such as CD63 and ALIX, and the absence of the markers GM130 and Cyto-C were confirmed. In vivo, FLI indicated an accumulation of i.v. injected IL4RPep-1-Flamma at the tumor site 90 min post-injection. No accumulation of NSSSVDK-Flamma was detected. In vivo, IL4RPep-1-EVs targeted the Cal-62 tumor 2 h post-injection. NSSSVDK-EVs were not even detected in the tumor 24 h post-injection. The quantification of FLI showed a significant accumulation of MSC-EVs in the tumor 2 h, 3 h, and 24 h post-injection. Furthermore, ex vivo imaging and an IF analysis confirmed the in vivo findings. Our results demonstrate the use of the IL4RPep-1 peptide as a targeting moiety of EVs for IL-4R-expressing anaplastic thyroid tumors. | Gangadaran, Prakash; Gunassekaran, Gowri Rangaswamy; Rajendran, Ramya Lakshmi; Oh, Ji Min; Vadevoo, Sri Murugan Poongkavithai; Lee, Ho Won; Hong, Chae Moon; Lee, Byungheon; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea | ; Lee, Sang-Jun/A-3892-2015; Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021 | 54393130400; 36028043400; 57195318729; 57190370462; 56663280000; 35337240700; 37050876700; 16304374900; 7601451907; 7202791511 | abc2000@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 1.49 | 2025-06-25 | 14 | 15 | interleukin-4 receptor; extracellular vesicles; IL-4R-binding peptide; anaplastic thyroid cancer; drug delivery | NATURAL-KILLER-CELLS; HYBRID PEPTIDE; IL-4 RECEPTORS; TUMOR-CELLS; EXOSOMES; EXOTOXIN; EXPRESSION; CHEMOTHERAPY; DOXORUBICIN; MEMBRANES | anaplastic thyroid cancer; drug delivery; extracellular vesicles; IL-4R-binding peptide; interleukin-4 receptor | English | 2022 | 2022-08 | 10.3390/biomedicines10081978 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Methylene Blue Delivery Mediated by Focused Ultrasound-Induced Blood-Brain Barrier Disruption Reduces Neural Damage and Amyloid-Beta Plaques by AQP-4 Upregulation | Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, causing progressive cognitive decline, memory impairment, and neurological deficits. Methylene blue (MB), an antioxidant, has emerged as a potential drug for the treatment of AD owing to its cognitive improvement and neuroprotective functions. Despite the small molecular size of MB, which can cross the BBB, the therapeutic effective dosage using a BBB-permeable delivery system in a specific brain localization remains unclear. In this study, we presented magnetic resonance-guided focused ultrasound (MRgFUS) as a delivery system to enhance BBB permeability for the effective treatment of AD. MRgFUS using two ultrasound intensities (0.25 and 0.32 MPa) was used to intravenously deliver MB to the hippocampal region. Compared with treatment with 0.25 MPa FUS, treatment with 0.32 MPa FUS significantly enhanced MB brain accumulation. Deposition of amyloid-beta (A beta) plaques and neural cell damage was significantly reduced in 0.32 MPa FUS/MB-treated APP/PS1 mice. Furthermore, aquaporin-4 expression increased significantly in the 0.32 MPa FUS and 0.32 MPa FUS/MB groups without glial fibrillary acidic protein activation. The results from this study demonstrate that FUS improved MB delivery to the brain, and FUS/MB combination treatment reduced the number of A beta plaques. This study revealed the potential of FUS-BBBD as an effective strategy to enhance the efficacy of therapeutic drugs for AD. | Choi, Hyo Jin; Han, Mun; Jung, Byeongjin; Hong, Yu-Ri; Shin, Seulgi; Lim, Sungsu; Lee, Eun-Hee; Kim, Yun Kyung; Park, Juyoung | Daegu Gyeongbuk Med Innovat Fdn K MEDI Hub, Med Device Dev Ctr, 80 Cheombok ro, Daegu 41061, South Korea; Daegu Technopark, 46 17 Seongseogongdan ro, Daegu 42716, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Joint Inst Regenerat Med, Daegu 41940, South Korea; Korea Inst Sci & Technol KIST, Brain Sci Inst, Ctr Brain Disorders, Seoul 02792, South Korea; Gachon Univ, Coll Future Ind, Dept High Tech Med Device, 1342 Seongnam daero, Seongnam 13120, South Korea | Kim, Kwang Pyo/AAG-1815-2020 | 57193758792; 55671172700; 57211508069; 57481287100; 57203238635; 56330649200; 57212665883; 57207443296; 55329181100 | ehlee@kmedihub.re.kr;yunkyungkim@kist.re.kr;opedoors@gachon.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 0.5 | 2025-06-25 | 6 | 5 | blood-brain barrier; focused ultrasound; methylene blue; Alzheimer's disease; aquaporin-4 | CEREBROSPINAL-FLUID; INTERSTITIAL FLUID; DISEASE; CLEARANCE; DRUG; FACILITATION; AQUAPORIN-4; DIAGNOSIS; EXCHANGE; MRI | Alzheimer’s disease; aquaporin-4; blood–brain barrier; focused ultrasound; methylene blue | English | 2022 | 2022-12 | 10.3390/biomedicines10123191 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil | Somatostatin (SST) is widely expressed in the brain and plays various, vital roles involved in neuromodulation. The purpose of this study is to characterize the organization of SST neurons in the Mongolian gerbil visual cortex (VC) using immunocytochemistry, quantitative analysis, and confocal microscopy. As a diurnal animal, the Mongolian gerbil provides us with a different perspective to other commonly used nocturnal rodent models. In this study, SST neurons were located in all layers of the VC except in layer I; they were most common in layer V. Most SST neurons were multipolar round/oval or stellate cells. No pyramidal neurons were found. Moreover, 2-color immunofluorescence revealed that only 33.50%, 24.05%, 16.73%, 0%, and 64.57% of SST neurons contained gamma-aminobutyric acid, calbindin-D28K, calretinin, parvalbumin, and calcium/calmodulin-dependent protein kinase II, respectively. In contrast, neuropeptide Y and nitric oxide synthase were abundantly expressed, with 80.07% and 75.41% in SST neurons, respectively. Our immunocytochemical analyses of SST with D-1 and D-2 dopamine receptors and choline acetyltransferase, alpha(7) and beta(2) nicotinic acetylcholine receptors suggest that dopaminergic and cholinergic fibers contact some SST neurons. The results showed some distinguishable features of SST neurons and provided some insight into their afferent circuitry in the gerbil VC. These findings may support future studies investigating the role of SST neurons in visual processing. | Kwon, Kyung-Min; Lee, Myung-Jun; Chung, Han-Saem; Pak, Jae-Hong; Jeon, Chang-Jin | Kyungpook Natl Univ, Brain Sci & Engn Inst, Coll Nat Sci, Sch Life Sci,Dept Biol,BK21 FOUR KNU Creat Biores, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Res Inst Dok Do & Ulleung Do Isl, Dept Biol, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Dept Biol, Daegu 41566, South Korea | 57218105460; 57218103547; 57396817500; 7102232932; 7006894339 | us3469@knu.ac.kr;bridlee900@knu.ac.kr;2018117591@knu.ac.kr;jhpak@knu.ac.kr;cjjeon@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 10 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2022 | 4.7 | 24.3 | 0.3 | 2025-06-25 | 3 | 3 | somatostatin; visual cortex; gamma-aminobutyric acid; calcium-binding proteins; calcium; calmodulin-dependent protein kinase II; dopamine receptors; nicotinic cholinergic receptors; Mongolian gerbil; immunocytochemistry | NITRIC-OXIDE SYNTHASE; EXPRESSING GABAERGIC INTERNEURONS; CALCIUM-BINDING PROTEINS; MONGOLIAN GERBIL; MERIONES-UNGUICULATUS; NEUROPEPTIDE-Y; IMMUNOCYTOCHEMICAL LOCALIZATION; CONTAINING NEURONS; CORTICAL-NEURONS; HUMAN BRAIN | Calcium-binding proteins; Calcium/calmodulin-dependent protein kinase II; Dopamine receptors; Gamma-aminobutyric acid; Immunocytochemistry; Mongolian gerbil; Nicotinic cholinergic receptors; Somatostatin; Visual cortex | English | 2022 | 2022-01 | 10.3390/biomedicines10010092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Concomitant Administration of Red Ginseng Extract with Lactic Acid Bacteria Increases the Plasma Concentration of Deglycosylated Ginsenosides in Healthy Human Subjects | With the increased frequency of red ginseng extract (RGE) and lactic acid bacteria (LAB) co-administration, we aimed to investigate the interactions between RGE and LAB with regard to in vitro and in vivo deglycosylation metabolism and the pharmacokinetics of ginsenosides. As a proof-of-concept study, five healthy humans were administered RGE (104.1 mg of total ginsenosides/day) with or without co-administration of LAB (2 g, 1 billion CFU/day) for 2 weeks, and the plasma concentrations of ginsenosides in human plasma were monitored. The plasma exposure to compound K (CK), ginsenoside Rh2 (GRh2), protopanaxadiol (PPD), and protopanaxatriol (PPT) in the concomitant administration RGE and LAB groups increased by 2.7-, 2.1-, 1.6-, and 3.5-fold, respectively, compared to those in the RGE administration group, without a significant change in T-max. The plasma concentrations of GRb1, GRb2, and GRc remained unchanged, whereas the AUC values of GRd and GRg3 significantly decreased in the concomitant administration RGE and LAB groups. To understand the underlying mechanism, the in vitro metabolic activity of ginsenosides was measured during the fermentation of RGE or individual ginsenosides in the presence of LAB for 1 week. Consistent with the in vivo results, co-incubation with RGE and LAB significantly increased the formation rate of GRh2, CK, PPD, and PPT. These results may be attributed to the facilitated deglycosylation of GRd and GRg3 and the increased production of GRh2, CK, PPD, and PPT by the co-administration of LAB and RGE. In conclusion, LAB supplementation increased the plasma concentrations of deglycosylated ginsenosides, such as GRh2, CK, PPD, and PPT, through facilitated deglycosylation metabolism of ginsenosides in the intestine. | Jeon, Ji-Hyeon; Park, Jin-Hyang; Jeon, So Yeon; Pang, Minyeong; Choi, Min-Koo; Song, Im-Sook | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, BK21 FOUR Commun Based Intelligent Novel Drug Disc, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea | 57204685946; 57267338300; 57226815842; 57488599500; 8695781400; 7201564500 | minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 12 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022 | 5.5 | 24.4 | 0.94 | 2025-06-25 | 9 | 11 | deglycosylation metabolism; ginsenosides; lactic acid bacteria (LAB); pharmacokinetics; red ginseng extract (RGE) | HUMAN INTESTINAL BACTERIA; PANAX-GINSENG; COMPOUND K; IN-VITRO; PHARMACOKINETICS; TRANSFORMATION; METABOLISM; BIOTRANSFORMATION; CYTOCHROME-P450 | deglycosylation metabolism; ginsenosides; lactic acid bacteria (LAB); pharmacokinetics; red ginseng extract (RGE) | Ginsenosides; Humans; Lactobacillales; Panax; Plant Extracts; Research Subjects; ginseng extract; ginsenoside; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rc; ginsenoside Rd; ginsenoside Rg 3; ginsenoside Rh 2; protopanaxadiol; ginsenoside; ginsenoside M1; ginsenoside Rh 2; plant extract; adult; Article; Bifidobacterium bifidum; Bifidobacterium longum; blood level; Caco-2 cell line; deglycosylation; fermentation; ginseng; human; human cell; lactic acid bacterium; lactic acid fermentation; Lactobacillus acidophilus; liquid chromatography-mass spectrometry; liquid liquid extraction; male; mass spectrometry; metabolism; normal human; proof of concept; Lactobacillales; Panax; research subject | English | 2022 | 2022-12 | 10.3390/biom12121896 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction | Bone diseases such as osteoporosis are the result of osteoclast over-activation. There are many therapeutic agents from natural compounds inhibiting the formation of osteoclast that have been reported and are continuously being interested. Amygdalin (AD) is isolated from seeds of Prunus armeniaca L. which has many pharmaceutical effects; however, the effect of AD on osteoclast formation and function remains unknown. Therefore, the underlying mechanism of AD on RANKL-induced osteoclast in RAW 264.7 cells was investigated. Molecular docking simulation revealed that AD can bind to the active sites of RANKL with negative binding affinities. Through TRAP activity, bone resorption, and migration, AD effectively inhibited osteoclast differentiation and function. Expression of transcription factors, such as NFATc1, c-fos, and osteospecific genes (including dcstamp, acp5, ATP6v0d2, and ctsk results) showed an osteoclast differentiated inhibitory effect by AD treatment. In addition, RANKL-induced activation of MAPK, ER stress, and ROS levels in RANKL-induced osteoclast was significantly inhibited while antioxidant enzymes were recovered in the presence of AD. These results suggest that AD may be a potential candidate derived from natural sources for the treatment of osteoclast bone-related diseases. | Trang, Nguyen Minh; Kim, Eun-Nam; Lee, Hyun-Su; Jeong, Gil-Saeng | Keimyung Univ, Coll Pharm, Daegu 42601, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea | Nguyen, Minh Trang/HLX-0330-2023 | 57413100500; 57201655294; 57272028400; 57204396456 | ngminhtrang52@gmail.com;enkimpharm@gmail.com;hyunsu.lee@knu.ac.kr;gsjeong@cnu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 12 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022 | 5.5 | 24.4 | 1.29 | 2025-06-25 | 14 | 15 | amygdalin; RANKL; osteoclast; ROS; ER stress; molecular docking | APOPTOSIS | Amygdalin; ER stress; Molecular docking; Osteoclast; RANKL; ROS | Amygdalin; Cell Differentiation; Down-Regulation; Molecular Docking Simulation; NFATC Transcription Factors; Osteoclasts; 4',6 diamidino 2 phenylindole; acid phosphatase tartrate resistant isoenzyme; actin; amygdalin; catalase; initiation factor 2alpha; membrane protein; mitogen activated protein kinase; NFATc1 protein; osteoclast differentiation factor; protein c fos; reactive oxygen metabolite; stress activated protein kinase; superoxide dismutase; synaptophysin; unclassified drug; amygdalin; transcription factor NFAT; acp5 gene; animal cell; apricot; Article; assay; ATP6v0d2 gene; binding affinity; bone resorption assay; cell differentiation; cell migration; cell viability; chemoluminescence; controlled study; crystal structure; ctsk gene; cytotoxicity; dcstamp gene; down regulation; endoplasmic reticulum stress; enzyme active site; enzyme activity; enzyme linked immunosorbent assay; fluorescence; fluorescence microscopy; gene expression; high performance liquid chromatography; immunoglobulin heavy chain gene; in vitro study; molecular docking; mouse; MTT assay; nonhuman; nuclear magnetic resonance spectroscopy; osteoclast; osteolysis; oxidative stress; polyacrylamide gel electrophoresis; protein binding; protein phosphorylation; RAW 264.7 cell line; real time polymerase chain reaction; signal transduction; upregulation; Western blotting; cell differentiation; metabolism | English | 2022 | 2022-02 | 10.3390/biom12020256 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fungal transformation of mineral substrata of biodeteriorated medieval murals in Saint Sophia?s cathedral, Kyiv, Ukraine | Microbial activity following invasion of human-made structures and artifacts can have profound social and economic consequences including the permanent loss of cultural heritage. The unique frescoes in the 11th century Saint Sophia's Cathedral (Kyiv, Ukraine) have recently suffered from dark-spot biodeterioration. The aim of this work was to elucidate the microbial nature of biodeterioration and the biogeochemical processes occurring in the areas of the dark spots. Culture-independent approaches including scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS), micro-X-ray diffraction and real-time quantitative poly-merase chain reaction (qPCR) analysis were used in this study. SEM and qPCR data demonstrated that the main agents of fresco biodeterioration were mycelial fungi, with bacteria unlikely to play a major role in the devel-opment of the dark spots. SEM-EDS results showed that fungi colonization of the dark spotted areas resulted in mechanical and chemical weathering involving dissolution of mineral components of the plaster (mainly calcite) and displacement of mineral grains, which compromise the stability of the plaster or fresco. SEM-EDS also detected fungal biomineralization of secondary mycogenic minerals: calcium malate, hydrated aluminium and ferric phosphates. Biomineralization of calcium malate by fungi, as found in this study, is a rare biogeochemical phenomenon, possibly linked to the presence of calcite and nitrogen limitation. | Fomina, Marina; Cuadros, Javier; Pinzari, Flavia; Hryshchenko, Nataliya; Najorka, Jens; Gavrilenko, Marina; Hong, Ji Won; Gadd, Geoffrey Michael | NAS Ukraine, Zabolotny Inst Microbiol & Virol, Zabolotny Str 154, UA-03143 Kiev, Ukraine; Natl Reserve Sophia Kyiv, UA-01001 Kiev, Ukraine; Nat Hist Museum, Dept Earth Sci, London SW7 5BD, England; Nat Hist Museum, Dept Life Sci, London SW7 5BD, England; CNR, Inst Biol Syst, I-00015 Monterotondo, Italy; NAS Ukraine, Inst Mol Biol & Genet, UA-03680 Kiev, Ukraine; Nat Hist Museum, Core Res Labs, London SW7 5BD, England; Kyungpook Natl Univ, Daegu 41566, South Korea; Univ Dundee, Sch Life Sci, Geomicrobiol Grp, Dundee DD1 5EH, Scotland; China Univ Petr, Coll Chem Engn & Environm, State Key Lab Heavy Oil Proc, Beijing Key Lab Oil & Gas Pollut Control, 18 Fuxue Rd, Beijing 102249, Peoples R China | Fomina, Marina/JQW-0508-2023; Pinzari, Flavia/IUP-2725-2023; Gadd, Geoffrey/AAS-6971-2021 | 7006855910; 7005324543; 56019475900; 15750447000; 6507950547; 57872120200; 57201579963; 34770778600 | M.Fomina@ukr.net; | INTERNATIONAL BIODETERIORATION & BIODEGRADATION | INT BIODETER BIODEGR | 0964-8305 | 1879-0208 | 175 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENVIRONMENTAL SCIENCES | 2022 | 4.8 | 24.4 | 0.53 | 2025-06-25 | 6 | 8 | SaintSophia?s of Kyiv; Fresco deterioration; SEM-EDS; Micro-XRD; qPCR absolute abundance estimation; Ca-malate biomineralization | RDNA COPY NUMBER; METALS; ACID; DETERIORATION; MICROORGANISMS; GEOMYCOLOGY; ENVIRONMENT; PAINTINGS; CONCRETE; ROCKS | Ca-malate biomineralization; Fresco deterioration; Micro-XRD; qPCR absolute abundance estimation; Saint Sophia's of Kyiv; SEM-EDS | Aluminum compounds; Biodegradation; Biomineralization; Calcite; Calcium carbonate; Chemical stability; Deterioration; Energy dispersive spectroscopy; Fungi; Polymerase chain reaction; Weathering; X ray diffraction; Abundance estimation; Ca-malate biomineralization; Dark spots; Energy dispersive X ray spectroscopy; Fresco deterioration; Micro-XRD; Quantitative polymerase chain reaction; Quantitative polymerase chain reaction absolute abundance estimation; Saint sophium of kyiv; Scanning electron microscopy with energy dispersive X-ray spectroscopy; Scanning electron microscopy | English | 2022 | 2022-11 | 10.1016/j.ibiod.2022.105486 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Silicon as a Smart Fertilizer for Sustainability and Crop Improvement | Silicon (Si), despite being abundant in nature, is still not considered a necessary element for plants. Si supplementation in plants has been extensively studied over the last two decades, and the role of Si in alleviating biotic and abiotic stress has been well documented. Owing to the noncorrosive nature and sustainability of elemental Si, Si fertilization in agricultural practices has gained more attention. In this review, we provide an overview of different smart fertilizer types, application of Si fertilizers in agriculture, availability of Si fertilizers, and experiments conducted in greenhouses, growth chambers, and open fields. We also discuss the prospects of promoting Si as a smart fertilizer among farmers and the research community for sustainable agriculture and yield improvement. Literature review and empirical studies have suggested that the application of Si-based fertilizers is expected to increase in the future. With the potential of nanotechnology, new nanoSi (NSi) fertilizer applications may further increase the use and efficiency of Si fertilizers. However, the general awareness and scientific investigation of NSi need to be thoughtfully considered. Thus, we believe this review can provide insight for further research into Si fertilizers as well as promote Si as a smart fertilizer for sustainability and crop improvement. | Tayade, Rupesh; Ghimire, Amit; Khan, Waleed; Lay, Liny; Attipoe, John Quarshie; Kim, Yoonha | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Tayade, Rupesh/AAM-9652-2021; ghimire, amit/KCK-1842-2024; Khan, Waleed/AAW-1500-2021 | 57191753234; 57823220200; 57822855200; 57766509400; 57823581400; 57224866763 | rupesh.tayade@gmail.com;ghimireamit2009@gmail.com;waleedkhan.my@gmail.com;layliny22@gmail.com;jerryjohn2487@gmail.com;kyh1229@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 12 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022 | 5.5 | 24.4 | 2.2 | 2025-06-25 | 49 | 60 | silicon; fertilizers; agriculture; sustainability; abiotic and biotic stress; Si transporters | MEDIATED ALLEVIATION; DROUGHT STRESS; LEPIDOPTERA CRAMBIDAE; SUGARCANE BORER; NUTRIENT-UPTAKE; USE EFFICIENCY; HEAVY-METALS; EARLY GROWTH; SALT STRESS; PLANTS | abiotic and biotic stress; agriculture; fertilizers; Si transporters; silicon; sustainability | Agriculture; Fertilizers; Silicon; Stress, Physiological; fertilizer; silicon; agriculture; physiological stress | English | 2022 | 2022-08 | 10.3390/biom12081027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Use of Bacterial Extracellular Vesicles for Gene Delivery to Host Cells | Extracellular vesicles (EVs), which are nanosized membranous particles secreted from both prokaryotic and eukaryotic cells, can deliver various biological molecules, such as nucleic acids, proteins, and lipids, into recipient cells. However, contrary to what is known about eukaryotic EVs, whether bacterial EVs (bEVs) can be used as transporters for bioactive molecules is becoming a hot area of research. In this study, we electroporated enhanced green fluorescent protein (EGFP) genes and precursor microRNA of Cel-miR-39 (pre-Cel-miR-39) from isolated bEVs of Escherichia coli and Lactobacillus reuteri. The EGFP plasmid, synthetic EGFP RNA, and pre-Cel-miR-39 were successfully delivered into the murine microglial BV2 cells via bEVs. PCR and confocal microscopy analysis confirmed the transfer of the EGFP plasmid and RNA. The bEV-delivered exogenous pre-Cel-miR-39 was further processed into the mature form of Cel-miR-39; its incorporation into Ago2-a major component of the RNA-induced silencing complex-was assessed using RNA-immunoprecipitation-PCR. Taken together, bEVs can be used as vehicles to deliver genetic materials and for novel biotechnological applications, such as gene transfer and mRNA vaccines. | Kim, Su-Im; Ha, Jae Yeong; Choi, Song-Yi; Hong, Su-Hyung; Lee, Heon-Jin | Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, Daegu 41940, South Korea; Kyungpook Natl Univ, Craniofacial Nerve Bone Network Res Ctr, Daegu 41940, South Korea | 57897876300; 57220581488; 57210356632; 8691449100; 36462383000 | heonlee@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 12 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2022 | 5.5 | 24.4 | 0.6 | 2025-06-25 | 9 | 8 | extracellular vesicle; microRNA; vaccine; gene delivery | extracellular vesicle; gene delivery; microRNA; vaccine | Animals; Extracellular Vesicles; Gene Transfer Techniques; Lipids; Mice; MicroRNAs; RNA-Induced Silencing Complex; enhanced green fluorescent protein; green fluorescent protein; messenger RNA; microRNA; RNA induced silencing complex; virus DNA; lipid; microRNA; RNA induced silencing complex; adipose derived stem cell; antimicrobial activity; Article; BV-2 cell line; CD4 lymphocyte count; cell viability; confocal microscopy; electron microscopy; exosome; flow cytometry; fluorescence microscopy; gene delivery system; genetic analysis; genetic transfection; host cell; immunoprecipitation; MTT assay; nonhuman; plasmid; polymerase chain reaction; real time polymerase chain reaction; RNA extraction; spinal muscular atrophy; transmission electron microscopy; ultracentrifugation; virus load; virus replication; animal; gene transfer; genetics; metabolism; mouse | English | 2022 | 2022-09 | 10.3390/biom12091171 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Circuit-Level Exploration of Ternary Logic Using Memristors and MOSFETs | In recent decades, the performance of binary computers has escalated through transistor scaling. However, due to the impotent forecasts of transistor scaling, ternary systems are regaining attention. Among many ternary device candidates, a passive device called memristor that is based on resistance switching is considered a good candidate when integrated with MOSFETs. Therefore, in this paper, we design various terna-ry logic based on memristors and MOSFETs from primitive logic to sequential logic and perform a thorough diagnosis for circuit design. We highlight design issues that should be resolved (e.g., signal distortion and high static current) and present practical solutions such as “Strength Design.” Then, we report a proper design methodology of sequential circuits considering the spike phenomena of memristor-based gates. We present 16 novel ternary logic cells and circuitry, including the design of the first balanced ternary full-adder (TFA) and memristor-based ternary pulsed-latch (MTPL). By our TFA, we emphasize that it is possible to design the most practical ternary circuits using memristors and MOSFETs. Our TFA uses 97 transistors and 87 memristors, which is the most reasonable TFA design that has the highest potential to be implemented in the near future. Besides, the proposed MTPL uses 16 transistors and 10 memristors, and it occupies only 72.7% of the silicon area, compared to the master-slave ternary flip-flop. © 2021 IEEE. | Yang, Jeonggyu; Lee, Hyundong; Jeong, Jae Hoon; Kim, Taehak; Lee, Sin-Hyung; Song, Taigon | Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea | 57221952581; 57226892881; 57226881576; 57225038681; 57226880204; 36005021000 | tsong@knu.ac.kr; | IEEE Transactions on Circuits and Systems I: Regular Papers | IEEE T CIRCUITS-I | 1549-8328 | 1558-0806 | 69 | 2 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2022 | 5.1 | 24.5 | 2.82 | 2025-06-25 | 37 | CNTFETs; Impedance; Logic gates; Memristors; Multivalued logic; Resistance; Voltage | Adders; Computer circuits; Flip flop circuits; Integrated circuit manufacture; Logic design; Logic devices; Memristors; MOSFET devices; Semiconductor junctions; Static random access storage; CNTFET; Full adders; Impedance; Memristor; Memristor.; Pulsed latches; Resistance; Ternary full-adder; Ternary logic; Ternary pulsed-latch; Many valued logics | English | Final | 2022 | 10.1109/tcsi.2021.3121437 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | A Novel Synthesized 1D Nanobelt-like Cobalt Phosphate Electrode Material for Excellent Supercapacitor Applications | In the present report, we synthesized highly porous 1D nanobelt-like cobalt phosphate (Co2P2O7) materials using a hydrothermal method for supercapacitor (SC) applications. The physicochemical and electrochemical properties of the synthesized 1D nanobelt-like Co2P2O7 were investigated using X-ray diffraction (XRD), X-ray photoelectron (XPS) spectroscopy, and scanning electron microscopy (SEM). The surface morphology results indicated that the deposition temperatures affected the growth of the 1D nanobelts. The SEM revealed a significant change in morphological results of Co2P2O7 material prepared at 150 degrees C deposition temperature. The 1D Co2P2O7 nanobelt-like nanostructures provided higher electrochemical properties, because the resulting empty space promotes faster ion transfer and improves cycling stability. Moreover, the electrochemical performance indicates that the 1D nanobelt-like Co2P2O7 electrode deposited at 150 degrees C deposition temperature shows the maximum specific capacitance (Cs). The Co2P2O7 electrode prepared at a deposition temperature 150 degrees C provided maximum Cs of 1766 F g(-1) at a lower scan rate of 5 mV s(-1) in a 1 M KOH electrolyte. In addition, an asymmetric hybrid Co2P2O7//AC supercapacitor device exhibited the highest Cs of 266 F g(-1), with an excellent energy density of 83.16 Wh kg(-1), and a power density of 9.35 kW kg(-1). Additionally, cycling stability results indicate that the 1D nanobelt-like Co2P2O7 material is a better option for the electrochemical energy storage application. | Shinde, S. K.; Jalak, Monali B.; Karade, Swapnil S.; Majumder, Sutripto; Tamboli, Mohaseen S.; Nguyen Tam Nguyen Truong; Maile, Nagesh C.; Kim, Dae-Young; Jagadale, Ajay D.; Yadav, H. M. | Dongguk Univ, Coll Life Sci & Biotechnol, Dept Biol & Environm Sci, Biomed Campus,32 Dongguk Ro, Goyang Si 10326, South Korea; Shivaji Univ, Dept Phys, Kolhapur 416004, Maharashtra, India; Univ Southern Denma 8 Rk, Dept Green Technol, Campusvej 55, DK-5230 Odense, Denmark; Yeungnam Univ, Dept Phys, Gyongsan 38541, South Korea; Korea Inst Energy Technol KENTECH, 200 Hyeokshin Ro, Naju 58330, South Korea; Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; SASTRA Deemed Univ, Ctr Energy Storage & Convers, Sch Elect & Elect Engn, Thanjavur 613401, India; Shivaji Univ, Sch Nanosci & Biotechnol, Kolhapur 416004, Maharashtra, India | ; Majumder, Sutripto/O-4611-2015; Jagadale, Ajay/O-5253-2014; Karade, Swapnil/AAA-8285-2020; Maile, Nagesh/AFD-8838-2022 | 55776351000; 57203877390; 56674484600; 55822965457; 6506784566; 25958384000; 57193804539; 55742887400; 44161199800; 55389590800 | surendraphy09@gmail.com;tamnguyentn@ynu.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 15 | 22 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 3.4 | 24.7 | 1 | 2025-06-25 | 12 | 12 | Co2P2O7; hydrothermal method; 1D nanobelt; hybrid asymmetric supercapacitor | HYBRID ENERGY-STORAGE; COP NANOWIRE ARRAYS; THIN-FILMS; FACILE SYNTHESIS; PERFORMANCE; CARBON; MNO2 | 1D nanobelt; Co<sub>2</sub>P<sub>2</sub>O<sub>7</sub>; hybrid asymmetric supercapacitor; hydrothermal method | Deposition; Electrochemical electrodes; Electrochemical properties; Electrolytes; Morphology; Nanobelts; Physicochemical properties; Potassium hydroxide; Scanning electron microscopy; Supercapacitor; Surface morphology; 150 ° C; 1d nanobelt; Asymmetric supercapacitor; Cycling stability; Deposition temperatures; Electrode material; Hybrid asymmetric supercapacitor; Hydrothermal methods; Supercapacitor application; Synthesised; Cobalt compounds | English | 2022 | 2022-11 | 10.3390/ma15228235 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Analysis for DC and RF Characteristics Recessed-Gate GaN MOSFET Using Stacked TiO2/Si3N4 Dual-Layer Insulator | The self-heating effects (SHEs) on the electrical characteristics of the GaN MOSFETs with a stacked TiO2/Si3N4 dual-layer insulator are investigated by using rigorous TCAD simulations. To accurately analyze them, the GaN MOSFETs with Si3N4 single-layer insulator are conducted to the simulation works together. The stacked TiO2/Si3N4 GaN MOSFET has a maximum on-state current of 743.8 mA/mm, which is the improved value due to the larger oxide capacitance of TiO2/Si3N4 than that of a Si3N4 single-layer insulator. However, the electrical field and current density increased by the stacked TiO2/Si3N4 layers make the device's temperature higher. That results in the degradation of the device's performance. We simulated and analyzed the operation mechanisms of the GaN MOSFETs modulated by the SHEs in view of high-power and high-frequency characteristics. The maximum temperature inside the device was increased to 409.89 K by the SHEs. In this case, the stacked TiO2/Si3N4-based GaN MOSFETs had 25%-lower values for both the maximum on-state current and the maximum transconductance compared with the device where SHEs did not occur; R-on increased from 1.41 m omega center dot cm(2) to 2.56 m omega center dot cm(2), and the cut-off frequency was reduced by 26% from 5.45 GHz. Although the performance of the stacked TiO2/Si3N4-based GaN MOSFET is degraded by SHEs, it shows superior electrical performance than GaN MOSFETs with Si3N4 single-layer insulator. | Min, So-Ra; Cho, Min-Su; Lee, Sang-Ho; Park, Jin; An, Hee-Dae; Kim, Geon-Uk; Yoon, Young-Jun; Seo, Jae-Hwa; Jang, Jae-Won; Bae, Jin-Hyuk; Lee, Sin-Hyung; Kang, In-Man | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Atom Energy Res Inst, Korea Multipurpose Accelerator Complex, Gyeongju 38180, South Korea; Korea Electrotechnol Res Inst, Power Semicond Res Ctr, Chang Won 51543, South Korea | Lee, Sang Ho/MCX-8396-2025; Lee, Sin-Hyung/ABD-6425-2022; Seo, Jae Hwa/KYP-7367-2024 | 57671524600; 57188742288; 57416738400; 57376422900; 57539074100; 57727029200; 57218864885; 58837410100; 57194107504; 35326180700; 57226880204; 7203062678 | minsora0716@gmail.com;chominsu14@knu.ac.kr;jim782jim@naver.com;jdefs12@naver.com;gmleo3396@naver.com;kku563@naver.com;yjyoon@kaeri.re.kr;seojeahwa@naver.com;j1jang@knu.ac.kr;jhbae@ee.knu.ac.kr;sinhlee@knu.ac.kr;imkang@ee.knu.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 15 | 3 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2022 | 3.4 | 24.7 | 0.42 | 2025-06-25 | 5 | 5 | gallium nitride (GaN); aluminum gallium nitride (AlGaN); self-heating effect (SHE); dual-layer insulator; silicon nitride (Si3N4); titanium dioxide (TiO2); sapphire; silicon carbide (SiC); radio frequency (RF) | ALGAN/GAN HEMTS; MIS-HEMT; MOBILITY; CONDUCTIVITY; DEVICE; TRAPS | Aluminum gallium nitride (AlGaN); Dual-layer insulator; Gallium nitride (GaN); Radio frequency (RF); Sapphire; Self-heating effect (SHE); Silicon carbide (SiC); Silicon nitride (Si<sub>3</sub> N<sub>4</sub> ); Titanium dioxide (TiO<sub>2</sub> ) | Aluminum gallium nitride; Aluminum nitride; Gallium nitride; III-V semiconductors; MOSFET devices; Sapphire; Semiconductor alloys; Titanium dioxide; Wide band gap semiconductors; Aluminum gallium nitride; Dual-layer insulator; Dual-layers; Gallium nitride; Radio frequency; Radiofrequencies; Self-heating effect; Silicon carbide; Silicon nitride (si3 N4 ); Titania dioxide (TiO2 ); Titanium dioxide (TiO 2); Silicon carbide | English | 2022 | 2022-02 | 10.3390/ma15030819 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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