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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Peptide-mediated targeted delivery of SOX9 nanoparticles into astrocytes ameliorates ischemic brain injury | Astrocytes are highly activated following brain injuries, and their activation influences neuronal survival. Additionally, SOX9 expression is known to increase in reactive astrocytes. However, the role of SOX9 in activated astrocytes following ischemic brain damage has not been clearly elucidated yet. Therefore, in the present study, we investigated the role of SOX9 in reactive astrocytes using a poly-lactic-co-glycolic acid (PLGA) nanoparticle plasmid delivery system in a photothrombotic stroke animal model. We designed PLGA nanoparticles to exclusively enhance SOX9 gene expression in glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes. Our observations indicate that PLGA nanoparticles encapsulated with GFAP:SOX9:tdTOM reduce ischemia-induced neurological deficits and infarct volume through the prostaglandin D2 pathway. Thus, the astrocyte-targeting PLGA nanoparticle plasmid delivery system provides a potential opportunity for stroke treatment. Since the only effective treatment currently available is reinstating the blood supply, cell-specific gene therapy using PLGA nanoparticles will open a new therapeutic paradigm for brain injury patients in the future. © 2024 The Royal Society of Chemistry. | Shin, Hyo Jung; Choi, Seung Gyu; Qu, Fengrui; Yi, Min-Hee; Lee, Choong-Hyun; Kim, Sang Ryong; Kim, Hyeong-Geug; Beom, Jaewon; Yi, Yoonyoung; Kim, Do Kyung; Joe, Eun-Hye; Song, Hee-Jung; Kim, Yonghyun; Kim, Dong Woon | Department of Medical Science, Chungnam National University, Daejeon, 35015, South Korea, Department of Anatomy and Cell Biology, Chungnam National University, Daejeon, 35015, South Korea, Brain Research Institute, Chungnam National University, Daejeon, 35015, South Korea; Department of Medical Science, Chungnam National University, Daejeon, 35015, South Korea, Department of Anatomy and Cell Biology, Chungnam National University, Daejeon, 35015, South Korea; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, 35487, AL, United States; Department of Neurology, Mayo Clinic, Rochester, 55905, MN, United States; Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 31116, South Korea; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Brain Science and Engineering Institute, Kyungpook National University, Daegu, 41566, South Korea; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, 46202, IN, United States; Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, South Korea; Department of Pediatrics, College of Medicine, Hallym University and Gangdong Sacred Heart Hospital, Seoul, 05355, South Korea; Department of Anatomy, College of Medicine, Konyang University, Daejeon, 35365, South Korea; Neuroscience Graduate Program, Department of Biomedical Sciences, Ajou University School of Medicine, Worldcup-ro 164, Kyunggi-do, Suwon, 16499, South Korea; Department of Neurology, Chungnam National University and Sejong Hospital, Sejong, 30099, South Korea; Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, 35487, AL, United States; Department of Medical Science, Chungnam National University, Daejeon, 35015, South Korea, Department of Anatomy and Cell Biology, Chungnam National University, Daejeon, 35015, South Korea, Brain Research Institute, Chungnam National University, Daejeon, 35015, South Korea | 57195753989; 57216935271; 57194338931; 55376066200; 34872707900; 56486163800; 36522994700; 36445178500; 57211298149; 37161387300; 7006591330; 26535323600; 56080532000; 57204150578 | ykim@eng.ua.edu;visnu528@cnu.ac.kr; | Nanoscale | NANOSCALE | 2040-3364 | 2040-3372 | 16 | 2 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 5.8 | 18.2 | 0.31 | 2025-06-25 | 3 | Animals; Astrocytes; Brain; Brain Injuries; Humans; Nanoparticles; Peptides; SOX9 Transcription Factor; Stroke; DNA; Gene expression; Gene therapy; Neurons; Patient treatment; nanoparticle; peptide; SOX9 protein, human; transcription factor Sox9; Animal model; Brain damage; Brain injury; Delivery systems; Genes expression; Glial fibrillary acidic proteins; Neuronal survival; Poly lactic-co-glycolic acid; Poly(lactic-co-glycolic acid); Targeted delivery; animal; astrocyte; brain; brain injury; cerebrovascular accident; genetics; human; metabolism; Nanoparticles | English | Final | 2023 | 10.1039/d3nr01318a | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Sinapic acid alleviates inflammatory bowel disease (IBD) through localization of tight junction proteins by direct binding to TAK1 and improves intestinal microbiota | Introduction: Although sinapic acid is found in various edible plants and has been shown to have anti-inflammatory properties including colitis, its underlying mechanism and effects on the composition of the gut microbiota are largely unknown. We aimed to identify an early response kinase that regulates the localization of tight junction proteins, act at the onset of the inflammatory response, and is regulated by sinapic acid. Additionally, we analyzed the effects of sinapic acid on the homeostasis of the intestinal microbiome. Methods: We examined the aberrant alterations of early response genes such as nuclear factor-kappa B (NF-kappa B) and activating transcription factor (ATF)-2 within 2 h of sinapic acid treatment in fully differentiated Caco-2 cells with or without lipopolysaccharide and tumor necrosis factor (TNF)-alpha stimulation. To confirm the effect of sinapic acid on stimulus-induced delocalization of tight junction proteins, including zonula occludens (ZO)-1, occludin, and claudin-2, all tight junction proteins were investigated by analyzing a fraction of membrane and cytosol proteins extracted from Caco-2 cells and mice intestines. Colitis was induced in C57BL/6 mice using 2% dextran sulfate sodium and sinapic acid (2 or 10 mg/kg/ day) was administrated for 15 days. Furthermore, the nutraceutical and pharmaceutical activities of sinapic acid for treating inflammatory bowel disease (IBD) evaluated. Results: We confirmed that sinapic acid significantly suppressed the stimulusinduced delocalization of tight junction proteins from the intestinal cell membrane and abnormal intestinal permeability as well as the expression of inflammatory cytokines such as interleukin (IL)-1 ss and TNF-alpha in vitro and in vivo. Sinapic acid was found to bind directly to transforming growth factor beta-activated kinase 1 (TAK1) and inhibit the stimulus-induced activation of NF-kappa B as well as MAPK/ATF-2 pathways, which in turn regulated the expression of mitogen-activated protein kinase (MLCK). Dietary sinapic acid also alleviated the imbalanced of gut microbiota and symptoms of IBD, evidenced by improvements in the length and morphology of the intestine in mice with colitis. Discussion: These findings indicate that sinapic acid may be an effective nutraceutical and pharmaceutical agent for IBD treatment as it targets TAK1 and inhibits subsequent NF-kappa B and ATF-2 signaling. | Jang, Sehyeon; Kim, San; So, Bo Ram; Kim, Younghoon; Kim, Chang-Kil; Lee, Jeong Jae; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu, South Korea | Jung, SUNG KEUN/AGR-2623-2022 | 58142092600; 58142092500; 57218122440; 57861979600; 7409880701; 55915465100; 35310491400 | jeongjaelee@knu.ac.kr;skjung04@knu.ac.kr; | FRONTIERS IN PHARMACOLOGY | FRONT PHARMACOL | 1663-9812 | 14 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.4 | 18.2 | 2.72 | 2025-06-25 | 12 | 12 | sinapic acid; inflammatory bowel disease; early response gene; gut microbiota; transforming growth factor beta-activated kinase 1; activating transcription factor (ATF)-2 | CANCER; COLITIS; STRESS; IMPACT | activating transcription factor (ATF)-2; early response gene; gut microbiota; inflammatory bowel disease; sinapic acid; transforming growth factor beta-activated kinase 1 | 2 (2 amino 3 methoxyphenyl)chromone; activating transcription factor; activating transcription factor 2; bacteriocin; claudin 2; claudin 4; cytokine; dextran sulfate; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; ketamine; lipopolysaccharide; mitogen activated protein kinase; mitogen activated protein kinase p38; myosin light chain kinase; occludin; protein kinase B; protein ZO1; reactive oxygen metabolite; RNA 16S; sinapic acid; stress activated protein kinase; tight junction protein; transcription factor; transforming growth factor beta; transforming growth factor beta activated kinase 1; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; Bacteroidetes; C57BL 6 mouse; Caco-2 cell line; carcinogenesis; cell membrane; chemoluminescence; controlled study; cytosol; cytotoxicity; dextran sulfate sodium-induced colitis; diet; early response gene; electric resistance; enterohemorrhagic Escherichia coli; enzyme activity; Escherichia coli; female; Firmicutes; gastrointestinal motility; gene expression; Helicobacter pylori; histology; homeostasis; human; human cell; immunofluorescence; in vitro study; in vivo study; inflammatory bowel disease; intestine cell; intestine flora; Lactobacillus reuteri; microbial community; microbiome; mouse; MTT assay; nonhuman; protein expression; protein phosphorylation; reverse transcription polymerase chain reaction; signal transduction; tight junction; Western blotting | English | 2023 | 2023-08-15 | 10.3389/fphar.2023.1217111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Surface distortion of FeRu nanoparticles improves the hydrogen evolution reaction performance in alkaline media | Rational design of electrocatalysts, including an increased catalytic surface area, a unique surface structure, and improved conductivity, for facilitating the hydrogen evolution reaction (HER) is emerging as an important issue. In this work, we consider the engineering of catalyst surfaces as an effective and feasible way to accelerate the HER kinetics. By etching the surface Fe of FeRu alloy nanoparticles (NPs) using hydrofluoric acid (HF), a distorted catalytic surface of FeRu NPs was formed. The distorted surface of the HF-treated FeRu NPs was successfully analyzed by X-ray absorption spectroscopy, high-resolution photoemission spectroscopy, and electrochemical absorption/desorption experiments. The electrocatalytic HER activity of the HF-treated FeRu NPs demonstrated that surface distortion enhances the water dissociation reaction and the electron transfer rate. As a result, the surface-distorted FeRu NPs improved HER performances in alkaline media compared to the pristine FeRu alloy NP/C, commercial Ru/C, and the state-of-the-art Pt/C catalysts. | Kim, Hee Jin; Hong, Eunseo; Hong, Yonghoon; Kim, Jeonghyeon; Kabiraz, Mrinal Kanti; Kim, Young-Min; Lee, Hangil; Seo, Won Seok; Choi, Sang-Il | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Sogang Univ, Dept Chem, Seoul 04107, South Korea; Sungkyunkwan Univ SKKU, Dept Energy Sci, Suwon 16419, South Korea; Sookmyung Womens Univ, Dept Chem, Seoul 04310, South Korea | Kabiraz, Mrinal/AAE-6381-2020; Choi, Sang-Il/AGR-1133-2022; Choi, Sang-Il/N-7571-2013; Lee, Ha/ABF-6005-2020 | 57193334513; 58132974600; 57199903487; 57194560892; 57201400780; 57194113984; 12782757000; 35993579400; 56167600800 | easyscan@sookmyung.ac.kr;wsseo@sogang.ac.kr;sichoi@knu.ac.kr; | NANOSCALE | NANOSCALE | 2040-3364 | 2040-3372 | 15 | 12 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 5.8 | 18.2 | 0.83 | 2025-06-25 | 8 | 8 | SHELL NANOCRYSTALS; ELECTROCATALYSTS; OXIDATION; EFFICIENT; NANOCATALYST; NANOTUBES; CATALYST; PD | Binary alloys; Electrocatalysts; Etching; Hydrofluoric acid; Hydrogen; Nanoparticles; Photoelectron spectroscopy; Surface structure; X ray absorption spectroscopy; Acid treated; Alkaline media; Alloy nanoparticle; Catalyst surfaces; Catalytic surface area; Hydrogen evolution reactions; Rational design; Reaction performance; Surface distortion; Surface Fe; Iron alloys | English | 2023 | 2023-03-23 | 10.1039/d2nr05881b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The effects of health beliefs upon nature-based tourism during COVID-19: Cases from the United States and South Korea | This study examines the effects of health beliefs upon nature-based tourism (NBT) during COVID-19 by reporting the findings of a questionnaire that was administered to 278 Americans and 300 South Koreans. The perceived benefits changed the attitude and behavioral intentions toward NBT against COVID-19 in both countries. Intrapersonal barriers had a negative impact on participants' attitude in both countries, whereas structural barriers acting on behavioral intentions were only observed in the United States. Moreover, attitude significantly impacted behavioral intentions in both countries. Structural invariance tests using chi-square differences partially confirmed the moderating effects of nationality on certain paths. This study provides theoretical insights through the extended health belief model and theory of planned behavior. In addition, it offers practical insights by suggesting effective marketing tools for NBT in different cultures. | Lee, Kyung-Yur; Jeong, Ji Youn | Hanyang Univ, Tourism Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Dept Tourism, Daegu, South Korea | ; Jeong, Ji Youn/KBB-3881-2024 | 57210286937; 57190002456 | jjeong@knu.ac.kr; | JOURNAL OF LEISURE RESEARCH | J LEISURE RES | 0022-2216 | 2159-6417 | 54 | 2 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM;SOCIOLOGY | 2023 | 2.5 | 18.2 | 1.43 | 2025-06-25 | 8 | 8 | COVID-19; nature-based tourism; cross-national; HBM; TPB; leisure constraints | PLANNED BEHAVIOR; TRAVEL CONSTRAINTS; DECISION-MAKING; SELF-EFFICACY; MODEL; UNCERTAINTY; INTENTIONS; AVOIDANCE; SERVICES; CHINESE | COVID-19; cross-national; HBM; leisure constraints; nature-based tourism; TPB | South Korea; United States; COVID-19; ecotourism; health belief; pandemic; theoretical study; tourism | English | 2023 | 2023-03-15 | 10.1080/00222216.2022.2158764 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Valid design and evaluation of cathode and anode materials of aqueous zinc ion batteries with high-rate capability and cycle stability | Although non-aqueous lithium-ion batteries have a high gravimetric density, aqueous zinc-ion batteries (ZIBs) have recently been in the spotlight as an alternative, because ZIBs have characteristics such as high volumetric density, high ionic conductivity, eco-friendliness, low cost, and high safety. However, the improvement in electrochemical performance is limited due to insufficient rate capability and severe cycle fading of the vanadium-oxide-based cathode and zinc-metal-based anode material, which are frequently used as active materials for ZIBs. In addition, complex methods are required to prepare high-performance cathode and anode materials. Therefore, a simple yet effective strategy is needed to obtain high-performance anodes and cathodes. Herein, an ammonium vanadate nanofiber (AVNF) intercalated with NH4+ and H2O as a cathode material for ZIBs was synthesized within 30 minutes through a facile sonochemical method. In addition, an effective Al2O3 layer of 9.9 nm was coated on the surface of zinc foil through an atomic layer deposition technique. As a result, AVNF//60Al(2)O(3)@Zn batteries showed a high rate capability of 108 mA h g(-1) even at 20 A g(-1), and exhibited ultra-high cycle stability with a capacity retention of 94% even after 5000 cycles at a current density of 10 A g(-1). | Lee, Se Hun; Han, Juyeon; Cho, Tae Woong; Kim, Gyung Hyun; Yoo, Young Joon; Park, JuSang; Kim, Young Jun; Lee, Eun Jung; Lee, Sihyun; Mhin, Sungwook; Park, Sang Yoon; Yoo, Jeeyoung; Lee, Sang-Hwa | Seoul Natl Univ, Adv Inst Convergence Technol, Seoul 16229, South Korea; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Kyonggi Univ, Adv Mat Engn, Suwon 16227, South Korea | lee, wj/JNR-4926-2023; mhin, sungwook/Q-2680-2019; Yoo, Jeeyoung/AAH-1359-2019 | 57194053310; 57222146622; 58046177400; 57221045916; 36640342400; 55650305500; 58047064100; 57239965200; 58112890300; 23566788100; 57190687481; 56046607500; 57348391900 | yoonpark77@snu.ac.kr;jyoo@knu.ac.kr;sanghwalee@snu.ac.kr; | NANOSCALE | NANOSCALE | 2040-3364 | 2040-3372 | 15 | 8 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 5.8 | 18.2 | 1.14 | 2025-06-25 | 11 | 12 | RECENT PROGRESS; METAL ANODES; LIFE | Alumina; Anodes; Atomic layer deposition; Cathodes; Ions; Lithium-ion batteries; Sonochemistry; Vanadium compounds; Ammonium vanadate; Anode material; Cathode and anode; Cathodes material; Cycle stability; Design and evaluations; High rate capability; Ion batteries; Non-aqueous; Zinc ions; Aluminum oxide | English | 2023 | 2023-02-23 | 10.1039/d2nr06372g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | VRKeyLogger: Virtual keystroke inference attack via eavesdropping controller usage pattern in WebVR | WebVR is an emerging technology that allows users to experience VR (Virtual Reality) through typical web browsers, providing an integrated environment for various VR applications. One important problem of the VR technology is how to securely interact with users, in particular, implementing secure text input. A promising approach is to use a virtual keyboard rendered as a VR object. The VR user can enter certain text by clicking a sequence of virtual keys through the VR controllers, and the input text is handled in a secure way. However, despite the sensitivity of the input text, we found that there is a critical vulnerability that the VR controllers are not properly protected. The VR controller status can be disclosed to malicious entities, imposing a severe threat that an attacker's website can infer the input text by eavesdropping and analyzing the VR controller's movements. To accurately infer the input, the attacker should address two challenges: 1) determining which clicks correspond to the virtual keyboard and 2) identifying which key is pressed. In this paper, we propose a new keystroke inference attack framework, VRKeyLogger, that addresses such challenges with two key components: key-click classifier and key-click identifier. The key-click classifier effectively distinguishes clicks on the virtual keyboard based on the SVM classifier trained by the major features of the VR controller uses. The key-click identifier then accurately identifies which key is pressed by transforming the clicked position into the local coordinate system of the virtual keyboard. We implemented a proof-of-concept prototype and conducted a user study with nine participants. In the extensive user study with three real-world WebVR applications, our VRKeyLogger results in classification and identification accuracy of 93.98 and 96.8% on average, respectively. This implies that the proposed attack poses a serious threat to WebVR security. | Lee, Jiyeon; Kim, Hyosu; Lee, Kilho | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Chung Ang Univ, Sch Comp Sci & Engn, Seoul 06974, South Korea; Soongsil Univ, Sch AI Convergence, Seoul 06978, South Korea; Soongsil Univ, Dept Intelligent Semicond, Seoul 06978, South Korea | 58377757200; 56403545200; 55923454800 | khlee.cs@ssu.ac.kr; | COMPUTERS & SECURITY | COMPUT SECUR | 0167-4048 | 1872-6208 | 134 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS | 2023 | 4.8 | 18.2 | 1.12 | 2025-06-25 | 4 | 5 | Virtual reality; WebVR; Web security; Keystroke inference; Virtual keyboard; VR controller sensors; VR side-channel attack | Keystroke inference; Virtual keyboard; Virtual reality; VR controller sensors; VR side-channel attack; Web security; WebVR | Computer keyboards; Controllers; Security systems; Side channel attack; Support vector machines; Virtual addresses; Web browsers; Inference attacks; Keystroke inference; Side-channel attacks; Usage patterns; User study; Virtual Keyboards; Virtual reality controller sensor; Virtual reality side-channel attack; WEB security; WebVR; Virtual reality | English | 2023 | 2023-11 | 10.1016/j.cose.2023.103461 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A nationwide cohort study on incidence and mortality associated with extracranial vascular malformations | Extracranial vascular malformations are abnormal formations of blood vessels located outside the brain (extracranial) that develop during fetal development. They are caused by errors in the formation of blood vessels in the embryo and can affect various parts of the body, such as the head, neck, face, and other regions. Some malformations may be asymptomatic and only require monitoring, while others may cause significant health issues or cosmetic concerns and may need medical intervention. There are very few studies have investigated the nationwide incidence and quantitative mortality of vascular malformations in terms of their subtypes. Thus, this study aimed to determine the nationwide incidence and mortality associated with vascular malformations. This nationwide population-based study evaluated 70,517 patients with vascular malformations from 2008 to 2021. We evaluated the incidence and mortality associated with each subtype of vascular malformation. Furthermore, Cox regression analysis was used to evaluate the association between vascular malformation and mortality. The annual incidence (per 100,000 population) of overall vascular, venous, capillary, arteriovenous, and lymphatic malformations was 9.85, 1.48, 2.31, 0.24, and 5.82 cases, respectively. Patients with vascular malformations, except those with venous malformations, had higher mortality than the matched controls. Moreover, among the vascular malformation subgroups, the adjusted hazard ratio of mortality was the highest for arteriovenous malformations. This study revealed that the overall annual incidence of vascular malformations was 9.85 cases per 100,000 population in Korea from 2008 to 2021. The mortality of the matched general population was lower than that of patients with vascular malformations, except for those with venous malformations. Additionally, the adjusted hazard ratio for mortality associated with arteriovenous malformations was the highest among the vascular malformation subgroups. | Ryu, Jeong Yeop; Chang, Yong June; Lee, Joon Seok; Choi, Kang Young; Yang, Jung Dug; Lee, Seok-Jong; Lee, Jongmin; Huh, Seung; Kim, Ji Yoon; Chung, Ho Yun | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea | LEE, JIN/Q-3108-2018; Ryu, Jeong Yeop/GLQ-9419-2022; Lee, Jae-Hyun/ABE-3803-2020; Yang, Jung/R-7806-2019 | 56366349400; 57949685900; 56496041000; 57203745682; 55171704700; 56013454400; 55689919700; 7101832929; 57205408095; 7404007181 | chunghoyun@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 1.53 | 2025-06-25 | 12 | 13 | PORT-WINE STAINS; ARTERIOVENOUS-MALFORMATIONS; VENOUS MALFORMATIONS; NATURAL-HISTORY; HEAD; NECK; CLASSIFICATION; LYMPHANGIOMAS | Arteriovenous Malformations; Cohort Studies; Humans; Incidence; Vascular Malformations; Veins; arteriovenous malformation; cohort analysis; congenital blood vessel malformation; human; incidence; vein | English | 2023 | 2023-08-25 | 10.1038/s41598-023-41278-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A smart device for non-invasive ADL estimation through multi-environmental sensor fusion | This research paper introduces the Smart Plug Hub (SPH), a non-invasive system designed to accurately estimating a patient's Activities of Daily Living (ADL). Traditional methods for measuring ADL include interviews, remote video systems, and wearable devices that track behavior. However, these approaches have limitations, such as patient memory dependency, privacy violations, and careless device management. To address these limitations, SPH utilizes sensor fusion to analyze time-series environmental signals and accurately estimate a patient's ADL. We have effectively optimized the utilization of computing resources through the implementation of "device collaboration" in SPH to receive event data and segments portions of the time-series environmental signal. By segmenting the data into smaller segments, we extracted an analyzable dataset, which was processed by an edge device-SPH. We have conducted several experiments with the SPH, and our research has resulted in a significant 75% accuracy in the classification of patients' kitchen ADLs and an 85% accuracy in the classification of toilet ADLs. These activities include actions such as eating activities in the kitchen and typical activities performed in the toilet. These findings have substantial implications for the progress of healthcare and patient care, highlighting the potential uses of the SPH technology in the monitoring and improvement of daily living activities. | Kang, Homin; Lee, Cheolhwan; Kang, Soon Ju | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57952244800; 57216824872; 55666313900 | sjkang@ee.knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.24 | 2025-06-25 | 2 | 2 | INDOOR LOCALIZATION | Activities of Daily Living; Humans; daily life activity; human | English | 2023 | 2023-10-11 | 10.1038/s41598-023-44436-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA's analysis method | The DAMA/LIBRA collaboration has reported the observation of an annual modulation in the event rate that has been attributed to dark matter interactions over the last two decades. However, even though tremendous efforts to detect similar dark matter interactions were pursued, no definitive evidence has been observed to corroborate the DAMA/LIBRA signal. Many studies assuming various dark matter models have attempted to reconcile DAMA/LIBRA's modulation signals and null results from other experiments, however no clear conclusion can be drawn. Apart from the dark matter hypothesis, several studies have examined the possibility that the modulation is induced by variations in detector's environment or their specific analysis methods. In particular, a recent study presents a possible cause of the annual modulation from an analysis method adopted by the DAMA/LIBRA experiment in which the observed annual modulation could be reproduced by a slowly varying time-dependent background. Here, we study the COSINE-100 data using an analysis method similar to the one adopted by the DAMA/LIBRA experiment and observe a significant annual modulation, however the modulation phase is almost opposite to that of the DAMA/LIBRA data. Assuming the same background composition for COSINE-100 and DAMA/LIBRA, simulated experiments for the DAMA/LIBRA without dark matter signals also provide significant annual modulation with an amplitude similar to DAMA/LIBRA with opposite phase. Even though this observation does not directly explain the DAMA/LIBRA results directly, this interesting phenomenon motivates more profound studies of the time-dependent DAMA/LIBRA background data. | Adhikari, Govinda; Carlin, Nelson; Choi, JaeJin; Choi, Seonho; Ezeribe, Anthony; Franca, Luis Eduardo; Ha, Chang Hyon; Hahn, In Sik; Hollick, Sophia J.; Jeon, Eunju; Jo, Jay Hyun; Joo, Han Wool; Kang, Woon Gu; Kauer, Matthew; Kim, Bongho; Kim, Hongjoo; Kim, Jinyoung; Kim, Kyungwon; Kim, SungHyun; Kim, Sun Kee; Kim, Won Kyung; Kim, Yeongduk; Kim, Yong-Hamb; Ko, Young Ju; Lee, Doo Hyok; Lee, Eun Kyung; Lee, Hyunseok; Lee, Hyun Su; Lee, Hye Young; Lee, In Soo; Lee, Jaison; Lee, Jooyoung; Lee, Moo Hyun; Lee, Seo Hyun; Lee, Seung Mok; Lee, Yu Jin; Leonard, Douglas; Manzato, Bruno B.; Maruyama, Reina H.; Neal, Robert J.; Nikkel, James A.; Olsen, Stephen L.; Park, Byung Ju; Park, Hyang Kyu; Park, Hyeonseo; Park, Kangsoon; Park, Se Dong; Pitta, Ricardo L. C.; Prihtiadi, Hafizh; Ra, Sejin; Rott, Carsten; Shin, Keon Ah; Scarff, Andrew; Spooner, Neil J. C.; Thompson, William G.; Yang, Liang; Yu, Gyun Ho | Yale Univ, Dept Phys & Wright Lab, New Haven, CT 06520 USA; Univ Sao Paulo, Phys Inst, BR-05508090 Sao Paulo, Brazil; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; Inst Basic Sci IBS, Ctr Underground Phys, Daejeon 34126, South Korea; Univ Sheffield, Dept Phys & Astron, Sheffield S3 7RH, England; Chung Ang Univ, Dept Phys, Seoul 06973, South Korea; Ewha Womans Univ, Dept Sci Educ, Seoul 03760, South Korea; Inst Basic Sci IBS, Ctr Exot Nucl Studies, Daejeon 34126, South Korea; Univ Sci & Technol UST, IBS Sch, Daejeon 34113, South Korea; Univ Wisconsin Madison, Dept Phys, Madison, WI 53706 USA; Univ Wisconsin Madison, Wisconsin IceCube Particle Astrophys Ctr, Madison, WI 53706 USA; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Sejong Univ, Dept Phys, Seoul 05006, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea; Korea Univ, Dept Accelerator Sci, Sejong 30019, South Korea; Sungkyunkwan Univ, Dept Phys, Suwon 16419, South Korea; Univ Utah, Dept Phys & Astron, Salt Lake City, UT 84112 USA; Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA | ; Laranjeira Couto Pitta, Ricardo/K-4152-2018; Schneider Hahn, Ivanete/H-9015-2016; Thompson, William/H-2407-2011; KIM, Sun Kee/IQT-8178-2023; Maruyama, Reina/A-1064-2013; Lee, Seung Mok/JXM-0966-2024; Kim, Dae-Hyun/AAA-4463-2020; Kim, Hong Joo/AAE-1178-2022; Kauer, Matt/AAY-7581-2020; Ko, Young/AEI-0838-2022; Lee, Hye-Young/JEP-8044-2023 | 56811058500; 7006320391; 58263015500; 57199723894; 56300952200; 57219686017; 17342119700; 57192312712; 57196280330; 57204519171; 55575536700; 56375205700; 24401181300; 55196156000; 57204895670; 59051568100; 55477445000; 57209988432; 7601588326; 59102407800; 55492072500; 7410207253; 57196171764; 56030036300; 59808296300; 57226673940; 23477682800; 56113238600; 57199646872; 55816685400; 57226402706; 57204797944; 57198252980; 57257129200; 55902330700; 57201926038; 7201953933; 57211139944; 9334469000; 57211139925; 8916442800; 35227722100; 57204904910; 8455192000; 57216599536; 35225979300; 57207888152; 57208178150; 57188983477; 16480794500; 35227850400; 57203522213; 56300978900; 7005922145; 57200581630; 57192656960; 57208174900 | hyunsulee@ibs.re.kr;hafizhp@ibs.re.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 1.77 | 2025-06-25 | 11 | 15 | MODEL | article; simulation | English | 2023 | 2023-03-22 | 10.1038/s41598-023-31688-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea | Human malaria, transmitted by Anopheles mosquitoes, is the most predominant mosquito-borne disease that is responsible for hundreds of thousands of deaths worldwide each year. In the Republic of Korea (ROK), there are currently several hundred malaria cases annually, mostly near the demilitarized zone (DMZ). Eight species of Anopheles mosquitoes are currently known to be present in the ROK. Similar to other major malaria vectors in Africa and India, it is very challenging to morphologically differentiate Anopheles mosquitoes in the ROK due to their extremely similar morphology. In this study, wing geometric morphometrics (WGM) were used to differentiate the eight Anopheles species collected at six locations near the DMZ, Seoul and Pyeongtaek from April-October 2021. Phylogenetic analysis was also performed using cytochrome c oxidase subunit 1 (COI), internal transcribed spacer 2 (ITS2), and tyrosine hydroxylase (TH) genes for comparison with WGM analysis and to infer evolutionary relationships. The results of cross-validation (overall accuracy = 74.8%) demonstrated that species identification using WGM alone was not possible with a high accuracy for all eight species. While phylogenetic analyses based on the COI region could not clearly distinguish some species, the analysis based on ITS2 and TH was more useful for resolving the phylogenetic correlation of the eight species. Our results may improve Anopheles species identification strategies for effective identification and control of malaria vectors in the ROK. | Jeon, Jiseung; Kim, Heung Chul; Klein, Terry A.; Choi, Kwang Shik | Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea; U Inc, Daesakwan Ro 34 Gil, Seoul 04409, South Korea; Force Hlth Protect & Prevent Med, Med Dept Act Korea, 65th Med Brigade,Unit 15281, Pyeongtaek, AP 96271 USA; PSC 450, Box 75R, Pyeongtaek, AP 96206 USA; Kyungpook Natl Univ, Res Inst Phylogen & Evolut, Daegu 41566, South Korea | Jeon, Jiseung/NRB-6964-2025 | 58673027200; 8847173600; 7202313728; 36602283400 | ksc@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 3 | 3 | VIVAX INFECTION-RATES; R-PACKAGE; DIPTERA-CULICIDAE; HYRCANUS GROUP; VECTOR COMPETENCE; MALARIA MOSQUITO; WING SHAPE; GENE FLOW; EVOLUTION; SIGNAL | Animals; Anopheles; Humans; Malaria; Mosquito Vectors; Phylogeny; Republic of Korea; animal; Anopheles; genetics; human; malaria; mosquito vector; phylogeny; South Korea | English | 2023 | 2023-12-12 | 10.1038/s41598-023-49536-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Association of circulating serum free bioavailable and total vitamin D with cathelicidin levels among active TB patients and household contacts | The free hormone hypothesis postulates that the estimation of free circulating 25 (OH)D may be a better marker of vitamin D status and is of clinical importance compared to total vitamin D fraction. The unbound fraction is involved in biological activities since it is able to penetrate into the cell. Studies have shown that cathelicidin/LL-37 inhibits the growth of Mycobacterium tuberculosis in a vitamin D-dependent manner and therefore adequate vitamin D is required for its expression. The study aimed to determine the association between serum bioavailable and total vitamin D with LL-37 levels in ATB patients, LTBI, and individuals with no TB infection. This was a cross-sectional study in which bioavailable vitamin D and LL-37 levels were measured using competitive ELISA kits and total vitamin D was measured using electrochemilumiscence and consequently determined their association. The mean (SD) bioavailable vitamin D levels of the study participants were 3.8 ng/mL (2.6) and the median (IQR) of LL-37 levels were 320 ng/mL (160, 550 ng/mL). The mean (SD) of total vitamin D levels was 19.0 ng/mL (8.3) ng/mL. Similar weak correlations were observed between the bioavailable and total vitamin D with LL-37 levels, therefore, deviating from our hypothesis. | Acen, Ester Lilian; Worodria, William; Kateete, David Patrick; Olum, Ronald; Joloba, Moses L.; Akintola, Ashraf; Bbuye, Mudarshiru; Andia, Irene Biraro | Makerere Univ, Coll Hlth Sci, Sch Biomed Sci, Dept Physiol, Kampala, Uganda; Mulago Natl Referral Hosp, Dept Internal Med, Pulm Div, Kampala, Uganda; Makerere Univ, Coll Hlth Sci, Sch Biomed Sci, Dept Immunol & Mol Biol, Kampala, Uganda; Makerere Univ, Coll Hlth Sci Unit, Sch Med, Dept Internal Med, Kampala, Uganda; Uganda Virus Res Inst, MRC, Entebbe, Uganda; London Sch Hyg, Entebbe, Uganda; Trop Med Uganda Res Unit, Entebbe, Uganda; Kyungpook Natl Univ, Sch Ind Technol Adv, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Makerere Univ, Makerere Lung Inst Coll Hlth Sci, Kampala, Uganda | Akintola, Ashraf/KZU-7081-2024; Olum, Ronald/AAR-4279-2020; Kateete, David Patrick/HCH-5603-2022; ACEN, ESTER/IST-5057-2023 | 57193127116; 9943021600; 6505469141; 57216824749; 6603733958; 57218618629; 57255489800; 23988531500 | mulamester82@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.24 | 2025-06-25 | 3 | 2 | 25-HYDROXYVITAMIN D; AMERICANS; LL-37 | Cathelicidins; Cross-Sectional Studies; Humans; Mycobacterium tuberculosis; Vitamin D; Vitamins; cathelicidin; vitamin; vitamin D; cross-sectional study; human; Mycobacterium tuberculosis | English | 2023 | 2023-04-01 | 10.1038/s41598-023-32543-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Association of nonalcoholic fatty liver disease and venous thromboembolic disease in healthy adults in Korea: a nationwide study | Nonalcoholic fatty liver disease (NAFLD) can lead to a prothrombotic state, which significantly burdens public healthcare systems. This study investigated the relationship between NAFLD and the incidence of venous thromboembolism (VTE) in Korea using National Health Insurance Service-National Sample Cohort 2.0 data. A population-based retrospective cohort analysis was conducted on 472,212 healthy individuals who underwent national health check-ups in Korea from 2009 to 2014. NAFLD was defined using the fatty liver index (FLI). Multivariate Cox proportional hazards regression models were used to analyze the association between FLI and VTE. Individuals were categorized into four quartiles according to FLI values (first quartile [Q1], 0-5.7; second quartile [Q2], 5.8-15.3; third quartile [Q3], 15.4-37.2; and fourth quartile [Q4], > 37.2). The incidence of VTE tended to increase with increasing FLI values (Q1, 598 [0.5%]; Q2, 1,033 [0.9%]; Q3, 1,443 [1.2%]; and Q4, 1,425 [1.2%]). In the age- and sex-adjusted multivariate model, the hazard ratio (HR) (95% confidence interval [CI]) was 1.47 (1.33-1.62) for Q4 compared with Q1. After adjusting for clinical variables with P < 0.1 in the univariate analyses, the HR (95% CI) was 1.45 (1.30-1.62) for Q4 compared with Q1. FLI was related to VTE risk, as confirmed after adjusting for other risk factors. | Kim, Chang-Yeon; Kim, Namkyun; Roh, Jae-Hyung | Daegu Catholic Univ, Med Ctr, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Sejong Hosp, Sch Med, Dept Cardiol Internal Med, Sejong, South Korea | Kim, Yangdo/AAC-2495-2021 | 55887435100; 55887032700; 57216309871 | namkyun.kim@knu.ac.kr;jhroh80@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 3 | 3 | RISK; CIRRHOSIS; INFLAMMATION; THROMBOSIS | Adult; Humans; Non-alcoholic Fatty Liver Disease; Republic of Korea; Retrospective Studies; Venous Thromboembolism; Venous Thrombosis; adult; human; nonalcoholic fatty liver; retrospective study; South Korea; vein thrombosis; venous thromboembolism | English | 2023 | 2023-09-26 | 10.1038/s41598-023-42963-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Baseline Cohort Profile of the Korean Chronic Cough Registry: A Multicenter, Prospective, Observational Study | Purpose The Korean Chronic Cough Registry study was initiated to characterize patients with chronic cough (CC) and investigate their outcomes in real-world clinical practice. This report aims to describe the baseline cohort profile and study protocols. Methods This multicenter, prospective observational cohort study included newly referred CC patients and those already being treated for refractory or unexplained chronic cough (RUCC). Cough status was assessed using a visual analog scale, the Leicester Cough Questionnaire (LCQ), and the Cough Hypersensitivity Questionnaire (CHQ). Results A total of 610 patients (66.9% women; median age 59.0 years) were recruited from 18 centers, with 176 being RUCC patients (28.9%). The median age at CC onset was 50.1 years, and 94.4% had adult-onset CC (= 19 years). The median cough duration was 4 years. Compared to newly referred CC patients, RUCC patients had a longer cough duration (6.0 years vs. 3.0 years) but had fewer symptoms and signs suggesting asthma, rhinosinusitis, or gastroesophageal acid reflux disease. Subjects with RUCC had lower LCQ scores (10.3 +/- 3.3 vs. 11.6 +/- 3.6; P < 0.001) and higher CHQ scores (9.1 +/- 3.9 vs. 8.4 +/- 4.1; P = 0.024). There were no marked differences in the characteristics of cough between refractory chronic cough and unexplained chronic cough. Conclusions Chronic cough typically develops in adulthood, lasting for years. Cough severity and quality of life impairment indicate the presence of unmet clinical needs and insufficient cough control in real-world clinical practice. Longitudinal follow-up is warranted to investigate the natural history and treatment outcomes. | Jo, Eun-Jung; Lee, Ji-Hyang; Won, Ha-Kyeong; Kang, Noeul; Kang, Sung-Yoon; Lee, Seung Eun; Lee, Ji-Ho; Kim, Mi-Yeong; Shim, Ji-Su; An, Jin; Yoo, Youngsang; Park, So-Young; Kim, Byung-Keun; Moon, Ji-Yong; Park, Han-Ki; Kim, Min-Hye; Kwon, Hyouk-Soo; Kim, Sae-Hoon; Kim, Sang-Heon; Chang, Yoon-Seok; Kim, Sang-Hoon; Birring, Surinder S.; Lee, Byung-Jae; Song, Woo-Jung | Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Allergy & Clin Immunol, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Gastroenterol,Dept Med, Seoul 06351, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Incheon, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Internal Med, Busan, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Coll Med, Dept Pulm Allergy & Crit Care Med, Seoul, South Korea; Gangneung Asan Hosp, Dept Internal Med, Kangnung, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; Univ Coll Med, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Allergy & Clin Immunol, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea; Eulji Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kings Coll London, Fac Life Sci & Med, Ctr Human & Appl Physiol Sci, Sch Basic & Med Biosci, London, England | Lee, Jae-Hyun/ABE-3803-2020; Kang, Sung-Yoon/AAG-7523-2020; Kim, Min/R-7255-2018; Chang, Yoon-Seok/J-5628-2012; MOON, Ji-Yong/U-1476-2018; Won, Ha-Kyeong/AFL-4811-2022; Lee, JongGu/B-7384-2013; Lee, Seung Eun/ABG-1607-2021; Kim, Byung-Keun/N-4256-2018; Kim, Sang-Heon/L-1162-2016; Park, Han-Ki/AAY-3102-2020; MOON, Ji-yong/U-1476-2018; Birring, Surinder/GWU-6967-2022 | 55572136700; 57208203071; 57192190852; 57204092973; 55492809000; 57202327298; 57191286776; 55892381000; 57193221759; 57207952209; 57345593400; 59466241200; 36608393400; 58760742600; 57218664064; 58045929900; 35285863400; 35198322400; 58154851000; 55712986100; 57196226893; 6701451652; 27171988300; 37062104600 | leebj@skku.edu;swj0126@amc.seoul.kr; | LUNG | LUNG | 0341-2040 | 1432-1750 | 201 | 5 | SCIE | RESPIRATORY SYSTEM | 2023 | 4.6 | 18.3 | 2.36 | 2025-06-25 | 15 | 13 | Cough; Registries; Prospective studies; Patient outcome assessment | QUALITY-OF-LIFE; CHEST GUIDELINE; ADULTS; HEALTH; SYMPTOM; EXPANSIONS; MANAGEMENT; BURDEN; IMPACT; RFC1 | Cough; Patient outcome assessment; Prospective studies; Registries | Adult; Chronic Disease; Cough; Female; Gastroesophageal Reflux; Humans; Hypersensitivity; Male; Middle Aged; Prospective Studies; Quality of Life; Republic of Korea; acetylcysteine; ambroxol; amitriptyline; antihistaminic agent; antitussive agent; beta 2 adrenergic receptor stimulating agent; bronchodilating agent; codeine; corticosteroid; doxofylline; erdosteine; gabapentin; leukotriene receptor blocking agent; levdropropizine; macrolide; mosapride; pregabalin; proton pump inhibitor; pseudoephedrine; theobromine; theophylline; adult; aged; Article; asthma; chronic cough; clinical practice; cohort analysis; controlled study; disease duration; disease severity; faintness; fatigue; female; headache; hernia; human; Korean (people); major clinical study; male; multicenter study; observational study; outcome assessment; prospective study; quality of life; questionnaire; rhinosinusitis; rib fracture; thorax pain; urine incontinence; visual analog scale; chronic disease; clinical trial; complication; coughing; gastroesophageal reflux; hypersensitivity; middle aged; South Korea | English | 2023 | 2023-10 | 10.1007/s00408-023-00644-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing | Endoscopic tattooing with India ink is a popular method for identifying colonic lesions during minimally invasive surgery because it is highly challenging to localize lesions during laparoscopy. However, there is a perceived unmet need for the injection of India ink and carbon particle suspension due to various complications and inconstant durability during the perioperative period. In this study, carbon black-containing self-healing adhesive alginate/polyvinyl alcohol composite hydrogels were synthesized as endoscopic tattooing inks. Alginate (Alg) conjugated with phenylboronic acid (PBA) groups in the backbone was crosslinked with polyvinyl alcohol (PVA) because of the dynamic bonds between the phenylboronic acid in alginate and the cis-diol groups of PVA. The carbon black-incorporated Alg-PBA/PVA hydrogels exhibited self-healing and re-shapable properties, indicating that improved intraoperative localization could be achieved. In addition, the adhesive tattooing hydrogels were stably immobilized on the target regions in the intraperitoneal spaces. These carbon black-containing self-healing adhesive hydrogels are expected to be useful in various surgical procedures, including endoscopic tattooing. | Kwon, Hyung Jun; Shin, Hyun Ho; Hyun, Da Han; Yoon, Ghilsuk; Park, Jun Seok; Ryu, Ji Hyun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu 41404, South Korea; Wonkwang Univ, Dept Chem Engn, Iksan 54538, Jeonbuk, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41566, South Korea; Wonkwang Univ, Dept Carbon Convergence Engn, Iksan 54538, Jeonbuk, South Korea; Wonkwang Univ, ICT Fus Green Energy Res Inst, Iksan 54538, Jeonbuk, South Korea | ; Park, Joonhong/AAZ-9885-2020 | 57199757347; 57890302900; 58089142700; 57204691355; 35226761100; 57208277508 | parkjs0802@knu.ac.kr;jhryu4816@wku.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 4 | 4 | OPEN SURGERY; RECTAL-CANCER; INDIA INK; LOCALIZATION; SAFETY; ALGINATE | Carbon; Hydrogels; Laparoscopy; Polyvinyl Alcohol; Soot; Tattooing; benzeneboronic acid; carbon; ink; polyvinyl alcohol; polyvinyl alcohol hydrogel; hydrogel; laparoscopy; procedures; soot; tattooing | English | 2023 | 2023-02-02 | 10.1038/s41598-023-28113-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Characteristics of non-accidental injuries in children and adolescents in Asia: a cross-national, multicenter cohort study | Children and adolescents are vulnerable to non-accidental injury. Early identification and prevention rely on detailed epidemiological studies, which are limited in Asia. This retrospective study used the registry data of Pan-Asian Trauma Outcome Study (PATOS) from October 1, 2015 to December, 31, 2020. Pediatric patients (aged 24. The study enrolled 451 patients with non-accidental injuries, accounting for 2.81% of pediatric trauma events presented to an emergency department in the PATOS registry. The overall mortality rate was 0.9%, similar to those in Western countries. Mortality rate was high in preschool children (8.7%, p = 0.017) than in other age groups. The sex-specific incidence was higher in boys (3.10% vs. 2.13%, p = 0.001). In adolescents, more events occurred on the street (25.9%), whereas home remained the most common locale in girls of all ages. In the multivariable regression analysis, abdominal and multiple injuries were risk factors for major trauma. © The Author(s) 2023. | Wang, Po-Yuan; Tseng, Wei-Chieh; Lee, Meng-Chang; Hsu, Li-Min; Shin, Sang Do; Jamaluddin, Sabariah Faizah; Tanaka, Hideharu; Son, Do Ngoc; Hong, Ki Jeong; Riyapan, Sattha; Haedar, Ali; Chiang, Wen-Chu; Rao, Ramana; Abraham, George P.; Ramakrishnan, T.V.; Jamaluddin, Sabariah Faiwah; Mohidin, Mohd Amin Bin; Saim, Al-Hilmi; Kean, Lim Chee; Anthonysamy, Cecilia; Yssof, Shah Jahan Din Mohd; Ji, Kang Wen; Kheng, Cheah Phee; Ali, Shamila bt Mohamad; Ramanathan, Periyanayaki; Yang, Chia Boon; Chia, Hon Woei; Hamad, Hafidahwati binti; Ismail, Samsu Ambia; Abdullah, Wan Rasydan B. Wan; Kimura, Akio; Velasco, Bernadett; Gundran, Carlos D.; Convocar, Pauline; G.Sabarre, Nerissa; Tiglao, Patrick Joseph; Hong, Ki Jeong; Song, Kyoung Jun; Jeong, Joo; Moon, Sung Woo; Kim, Joo-Yeong; Cha, Won Chul; Lee, Seung Chul; Ahn, Jae Yun; Lee, Kang Hyeon; Yeom, Seok Ran; Ryu, Hyeon Ho; Kim, Su Jin; Kim, Sang Chul; Sun, Jen Tang; Wang, Ruei-Fang; Hsieh, Shang-Lin; Kao, Wei-Fong; Tianwibool, Parinya; Buaprasert, Phudit; Akaraborworn, Osaree; Al Sakaf, Omer Ahmed; LLC, Saleh Fares; Huy, Le Bao; Van Dai, Nguyen; Khruekarnchana, Pairoj | Department of Pediatrics, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, Medical College, National Taiwan University, Taipei, Taiwan, Department of Emergency Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan; Department of Emergency Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan; Department of Traumatology and Critical Care, National Taiwan University Hospital, Taipei, Taiwan; Department of Emergency Medicine, Seoul National University College of Medicine and Hospital, Seoul, South Korea; Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Malaysia; Graduate School of Emergency Medical Service System, Kokushikan University, Tokyo, Japan; Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Viet Nam, Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Viet Nam, Faculty of Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam; Department of Emergency Medicine, Seoul National University College of Medicine and Hospital, Seoul, South Korea; Department of Emergency Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand; Department of Emergency Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Emergency Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan, Department of Emergency Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Taiwan; GVK EMRI, Hyderabad, India; Indian Institute of Emergency Medical Services, Chennai, India; Sri Ramachandra Medical Center, Chennai, India; Sungai Buloh Hospital, Sungai Buloh, Malaysia; Sultanah Aminah Hospital, Johor, Malaysia; Seri Manjung Hospital, Seri Manjung, Malaysia; Pulau Pinang Hospital, Pulau Pinang, Malaysia; Serdang Hospital, Kajang, Malaysia; Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Sarikei Hospital, Sarikei, Malaysia; Sabah Women and Children’s Hospital, Kota Kinabalu, Malaysia; Ampang Hospital, Ampang, Malaysia; Kajang Hospital, Kajang, Malaysia; Miri Hospital, Miri, Malaysia; Sarawak General Hospital, Kuching, Malaysia; Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia; Teluk Intan Hospital, Teluk Intan, Malaysia; Raja Perempuan Zainab II Hospital, Kota Bharu, Malaysia; National Center for Global Health and Medicine Hospital, Tokyo, Japan; East Avenue Medical Center, Quezon City, Philippines; Philippine College of Emergency Medicine, Parañaque, Philippines; Southern Philippines Medical Center, Davao, Philippines; Pasig City General Hospital, Pasig, Philippines; Corazon Locsin Montelibano Memorial Regional Hospital, Bacolod, Philippines; Department of Emergency Medicine, Seoul National University College of Medicine and Hospital, Seoul, South Korea; Boramae Medical Center, Seoul, South Korea; Seoul National University Bundang Hospital, Seoul, South Korea; Korea University Ansan Hospital, Ansan, South Korea; Korea University Ansan Hospital, Ansan, South Korea; Samsung Medical Center, Seoul, South Korea; Dongguk University Ilsan Hospital, Goyang, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Pusan National University Hospital, Busan, South Korea; Chonnam National University Hospital, Gwangju, South Korea; Korea University Anam Hospital, Seoul, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 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57037616400; 39061606100; 8725859700; 54179487300; 26030262900; 55370162900; 56937505400; 57797786100; 25028912100; 57797786200; 57196044127; 7601581324; 35109830700; 16308461200; 57226285755; 7103156073; 57478877400; 57222981508; 56203577500; 57209314309; 59323852300; 57797551000; 26026174200; 6506870042 | littlecardiologist@gmail.com;drchiang.tw@gmail.com; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.35 | 2025-06-25 | 3 | Adolescent; Asia; Child; Child, Preschool; Emergency Service, Hospital; Female; Humans; Infant; Injury Severity Score; Male; Multiple Trauma; Retrospective Studies; Wounds and Injuries; adolescent; Asia; child; clinical trial; female; hospital emergency service; human; infant; injury; injury scale; male; multicenter study; multiple trauma; preschool child; retrospective study | English | Final | 2023 | 10.1038/s41598-023-33471-x | 바로가기 | 바로가기 | 바로가기 |
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