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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Characteristics and electrochemical performances of silicon/carbon nanofiber/graphene composite films as anode materials for binder-free lithium-ion batteries We report the interfacial study of a silicon/carbon nanofiber/graphene composite as a potentially high-performance anode for rechargeable lithium-ion batteries (LIBs). Silicon nanoparticle (Si)/carbon nanofiber (CNF)/reduced graphene oxide (rGO) composite films were prepared by simple physical filtration and an environmentally-friendly thermal reduction treatment. The films were used as high-performance anode materials for self-supporting, binder-free LIBs. Reducing graphene oxide improves the electron conductivity and adjusts to the volume change during repeated charge/discharge processes. CNFs can help maintain the structural stability and prevent the peeling off of silicon nanoparticles from the electrodes. When the fabricated Si/CNF/rGO composites were used as anodes of LIBs, the initial specific capacity was measured to be 1894.54 mAh/g at a current density of 0.1 A/g. After 100 cycles, the reversible specific capacity was maintained at 964.68 mAh/g, and the coulombic efficiency could reach 93.8% at the same current density. The Si/CNF/rGO composite electrode exhibited a higher specific capacity and cycle stability than an Si/rGO composite electrode. The Si/CNF/rGO composite films can effectively accommodate and buffer changes in the volume of silicon nanoparticles, form a stable solid-electrolyte interface, improve the conductivity of the electrode, and provide a fast and efficient channel for electron and ion transport. Cong, Ruye; Choi, Jin-Yeong; Song, Ju-Beom; Jo, Minsang; Lee, Hochun; Lee, Chang-Seop Keimyung Univ, Dept Chem, Daegu 42601, South Korea; Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea; DGIST, Dept Energy Sci & Engn, Daegu 42988, South Korea Lee, Chang-Seop/IQU-1791-2023; Cong, Ruye/IQU-1733-2023 57221554946; 57071954600; 57221558747; 57188669625; 7501476411; 57207257491 surfkm@kmu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 3.46 2025-07-30 81 75 REDUCED GRAPHENE OXIDE; CARBON NANOFIBERS; ELECTRODE MATERIALS; HIGH-CAPACITY; SI; NETWORK; NANOPARTICLES; FABRICATION English 2021 2021-01-14 10.1038/s41598-020-79205-1 바로가기 바로가기 바로가기 바로가기
Article Characterization and comparative analysis among plastome sequences of eight endemic Rubus (Rosaceae) species in Taiwan Genus Rubus represents the second largest genus of the family Rosaceae in Taiwan, with 41 currently recognized species across three subgenera (Chamaebatus, Idaoeobatus, and Malochobatus). Despite previous morphological and cytological studies, little is known regarding the overall phylogenetic relationships among the Rubus species in Taiwan, and their relationships to congeneric species in continental China. We characterized eight complete plastomes of Taiwan endemic Rubus species: subg. Idaeobatus (R. glandulosopunctatus, R. incanus, R. parviaraliifolius, R rubroangustifolius, R. taitoensis, and R. taiwanicolus) and subg. Malachobatus (R. kawakamii and R. laciniastostipulatus) to determine their phylogenetic relationships. The plastomes were highly conserved and the size of the complete plastome sequences ranged from 155,566 to 156,236 bp. The overall GC content ranged from 37.0 to 37.3%. The frequency of codon usage showed similar patterns among species, and 29 of the 73 common protein-coding genes were positively selected. The comparative phylogenomic analysis identified four highly variable intergenic regions (rps16/trnQ, petA/psbJ, rpl32/trnL-UAG, and trnT-UGU/trnL-UAA). Phylogenetic analysis of 31 representative complete plastomes within the family Rosaceae revealed three major lineages within Rubus in Taiwan. However, overall phylogenetic relationships among endemic species require broader taxon sampling to gain new insights into infrageneric relationships and their plastome evolution. Yang, JiYoung; Chiang, Yu-Chung; Hsu, Tsai-Wen; Kim, Seon-Hee; Pak, Jae-Hong; Kim, Seung-Chul Kyungpook Natl Univ, Sch Life Sci, Dept Biol, BK21 Four KNU Creat BioRes Grp, Daegu 41566, South Korea; Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan; Taiwan Endem Species Res Inst, 1 Mingshen East Rd, Chichi Township 55244, Nantou, Taiwan; Sungkyunkwan Univ, Dept Biol Sci, 2066 Seobu Ro, Suwon 16419, Gyeonggi Do, South Korea ; Chiang, Yu-Chung/E-9143-2011; Kim, Seung-Chul/AAR-6157-2020 55193226000; 7201593523; 7401791986; 57196226213; 7102232932; 57214983739 jhpak@knu.ac.kr;sonchus96@skku.edu; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 1.03 2025-07-30 22 22 CHLOROPLAST GENOME SEQUENCE; SYNONYMOUS CODON USAGE; DNA; PHYLOGENY; GENES; ASTERACEAE; EVOLUTION; SELECTION; ORIGIN; PLANT Evolution, Molecular; Genome, Plant; Phylogeny; Plastids; Rubus; Taiwan; article; codon usage; DNA base composition; endemic species; nonhuman; phylogeny; Rubus; Taiwan; taxon; comparative study; genetics; molecular evolution; plant genome; plastid; Rubus; Taiwan English 2021 2021-01-13 10.1038/s41598-020-80143-1 바로가기 바로가기 바로가기 바로가기
Article Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07BC, and a novel subtype CRF43₀₂G recombined with CRF02AG again, or a new CRF02AG and subtype G recombinant. For the ten NFLGs determined by NGS, "the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005". This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea. Ryou, Sangmi; Yoo, Myeongsu; Kim, Kisoon; Kim, Sangsoo; Kim, Sang Il; Kim, Youn Jeong; Park, Dae Won; Choi, Jun Yong; Kim, Hyo Youl; Kim, Jung Ho; Song, Joon Young; Kim, Shin-Woo; Chang, Hyun-Ha; Choi, Bo Youl; Kee, Mee-Kyung Korea Natl Inst Hlth, Div Viral Dis Res, Ctr Infect Dis Res, Cheongju, South Korea; Soongsil Univ, Dept Bioinformat & Life Sci, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Div Infect Dis, Dept Internal Med,Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, AIDS Res Inst, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Korea Univ, Div Infect Dis, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Hanyang Univ, Dept Prevent Med, Coll Med, Seoul, South Korea Kim, Yoon/G-6633-2015; Kim, Jong/AAH-5295-2020; Choi, Jah/AAA-4835-2022; Kim, Sang Soo/A-4448-2018 57212327522; 57211186635; 57205068175; 57201923850; 56941143600; 26659471500; 55724785200; 57791298700; 56819456800; 56657199800; 57214400146; 57189703358; 7407521688; 55663343300; 8212011900 keemeekyung@gmail.com; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.16 2025-07-30 3 3 MOLECULAR PHYLOGENETIC ANALYSIS; MOSAIC STRUCTURE; SAUDI-ARABIA; IDENTIFICATION; VIRUS; DIVERSITY; SEQUENCES; GENE; AMPLIFICATION; POPULATION Genome, Viral; Genotype; HIV Infections; HIV Seropositivity; HIV-1; Homosexuality, Male; Humans; Male; Phylogeny; Recombination, Genetic; Republic of Korea; Sequence Analysis, DNA; Sexual and Gender Minorities; DNA sequence; genetic recombination; genetics; genotype; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; male; male homosexuality; phylogeny; procedures; sexual and gender minority; South Korea; virology; virus genome English 2021 2021-02-18 10.1038/s41598-021-82872-3 바로가기 바로가기 바로가기 바로가기
Article Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6-plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (H2S) synthesis in the liver. This investigation provides novel evidence that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver. Na, Ann-Yae; Jo, Jung Jae; Kwon, Oh Kwang; Cho, Piljoung; Gao, Yan; Kim, Ju-Hyun; Kim, Kyu Min; Ki, Sung Hwan; Lee, Sangkyu Kyungpook Natl Univ, Coll Pharm, BK21 Four Community Based Intelligent Novel Drug, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Chosun Univ, Coll Pharm, Gwangju 61452, South Korea kim, kyumin/KDN-4319-2024 57201530058; 57191892087; 55579791200; 57202163312; 58736921100; 55720031300; 56441871900; 8346836500; 57209046767 shki@chosun.ac.kr;sangkyu@knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.16 2025-07-30 2 4 HYDROGEN-SULFIDE; ENDOTHELIAL-CELLS; ORAL TOXICITY; INHIBITION; LIVER; MECHANISMS; MEYER; P38 Alanine Transaminase; Animals; Aspartate Aminotransferases; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Humans; Hydrogen Sulfide; Hyperglycemia; Liver; Mice; Oxidative Stress; Panax; Plant Extracts; Proteomics; alanine aminotransferase; aspartate aminotransferase; cystathionine beta synthase; hydrogen sulfide; plant extract; animal; chemistry; comparative study; dose response; enzymology; human; hyperglycemia; liver; metabolism; mouse; oxidative stress; Panax; proteomics English 2021 2021-06-11 10.1038/s41598-021-91664-8 바로가기 바로가기 바로가기 바로가기
Article Characterization of metapopulation of Ellobium chinense through Pleistocene expansions and four covariate COI guanine-hotspots linked to G-quadruplex conformation The land snail Ellobium chinense (L. Pfeiffer, 1855) (Eupulmonata, Ellobiida, Ellobiidae), which inhabits the salt marshes along the coastal areas of northwestern Pacific, is an endangered species on the IUCN Red List. Over recent decades, the population size of E. chinense has consistently decreased due to environmental interference caused by natural disasters and human activities. Here, we provide the first assessment of the genetic diversity and population genetic structures of northwestern Pacific E. chinense. The results analyzed with COI and microsatellites revealed that E. chinense population exhibit metapopulation characteristics, retaining under the influence of the Kuroshio warm currents through expansion of the Late-Middle and Late Pleistocene. We also found four phylogenetic groups, regardless of geographical distributions, which were easily distinguishable by four unidirectional and stepwise adenine-to-guanine transitions in COI (sites 207-282-354-420: A-A-A-A, A-A-G-A, G-A-G-A, and G-G-G-G). Additionally, the four COI hotspots were robustly connected with a high degree of covariance between them. We discuss the role of these covariate guanines which link to form four consecutive G-quadruplexes, and their possible beneficial effects under positive selection pressure. Shin, Cho Rong; Choi, Eun Hwa; Kim, Gyeongmin; Baek, Su Youn; Park, Bia; Hwang, Jihye; Jun, Jumin; Kil, Hyun Jong; Oh, Hyunkyung; Lee, Kyungjin; Kim, Sa Heung; Lee, Jongrak; Suh, Seung Jik; Park, Dong-min; Suk, Ho Young; Lee, Yong Seok; Lee, Young Sup; Hwang, Ui Wook Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Grad Sch, Daegu 41566, South Korea; Natl Inst Biol Resources, Biol & Genet Resources Utilizat Div, Incheon 22689, South Korea; Inst Sea Life Divers, Sea, Incheon 63573, South Korea; Korea Natl Pk Serv, Byunsanbando Natl Pk Off, Buan Gun 56342, Jeonrabuk Do, South Korea; Yeungnam Univ, Dept Life Sci, Gyongsan 38541, Gyeongsangbuk D, South Korea; Soonchunhyang Univ, Coll Nat Sci, Dept Life Sci & Biotechnol, Asan 31538, Chungcheongnam, South Korea; Kyungpook Natl Univ, Inst Korean Herb Bio Convergence Promot, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Ind Technol Adv, Daegu 41566, South Korea LEE, YONGSEOK/AAF-3965-2020; Choi, Eun Hwa/HTN-1610-2023 57222521654; 57203556599; 57211378109; 57192371420; 57191834404; 57219609298; 54403070000; 57195241398; 58280820500; 57224450693; 57224442698; 57224440946; 57224453204; 57224443218; 7005704783; 57049824800; 36013628200; 35074015800 uwhwang1@gmail.com; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.54 2025-07-30 12 12 IBIS NIPPONIA-NIPPON; GENETIC-STRUCTURE; MICROSATELLITE MARKERS; POPULATION-GROWTH; FORMING SEQUENCES; DIVERSITY; SOFTWARE; ISLAND; SNAIL Animals; Electron Transport Complex IV; G-Quadruplexes; Gastropoda; Genetic Variation; Genetics, Population; Guanine; Humans; Microsatellite Repeats; Phylogeny; Phylogeography; cytochrome c oxidase; guanine; guanine quadruplex; microsatellite DNA; anatomy and histology; animal; chemistry; classification; gastropod; genetic variation; genetics; human; phylogeny; phylogeography; population genetics English 2021 2021-06-10 10.1038/s41598-021-91675-5 바로가기 바로가기 바로가기 바로가기
Article Circular noncoding RNA hsacᵢᵣc₀₀₀₅₉₈₆ as a prognostic biomarker for hepatocellular carcinoma Circular RNAs (circRNAs) represent potential biomarkers because of their highly stable structure and robust expression pattern in clinical samples. The aim of this study was to evaluate the expression of a recently identified circRNA, hsacᵢᵣc₀₀₀₅₉₈₆; determine its clinical significance; and evaluate its potential as a biomarker of hepatocellular carcinoma (HCC). We evaluated hsacᵢᵣc₀₀₀₅₉₈₆ expression in 123 HCC tissue samples, its clinical significance, and its association with patients' clinicopathological characteristics and survival. Hsacᵢᵣc₀₀₀₅₉₈₆ expression was downregulated in HCC tissues. Low hsacᵢᵣc₀₀₀₅₉₈₆ expression was more common in tumors larger than 5 cm [odds ratio (OR), 3.19; 95% confidence interval (CI), 1.51-6.76; p=0.002], advanced TNM stage (III/IV; OR, 2.39; 95% CI, 1.16-4.95; p=0.018), and higher BCLC stage (B/C; OR, 2.71; 95% CI, 1.30-5.65; p=0.007). High hsacᵢᵣc₀₀₀₅₉₈₆ expression was associated with improved survival and was an independent prognostic factor for overall [hazard ratio (HR), 0.572; 95% CI, 0.339-0.966; p=0.037] and progression-free (HR, 0.573; 95% CI, 0.362-0.906; p=0.017) survival. Moreover, the circRNA-miRNA-mRNA network was constructed using RNA-seq/miRNA-seq data and clinical information from TCGA-LIHC dataset. Our findings indicate a promising role for hsacᵢᵣc₀₀₀₅₉₈₆ as a prognostic biomarker in patients with HCC. Kim, Gyeonghwa; Han, Ja Ryung; Park, Soo Young; Tak, Won Young; Kweon, Young-Oh; Lee, Yu Rim; Han, Young Seok; Park, Jung Gil; Kang, Min Kyu; Lee, Hye Won; Lee, Won Kee; Kim, Deokhoon; Jang, Se Young; Hur, Keun Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, 170 Hyonchung Ro, Daegu 42415, South Korea; Keimyung Univ, Sch Med, Dept Pathol, 1035 Dalgubeol Daero, Daegu 42601, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Med Res Collaborat Ctr,Biostat, 135 Dongdeok Ro, Daegu 41940, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Olymp Ro 43 Gil 88, Seoul 05505, South Korea Hur, Keun/G-9513-2011; Kang, Min/U-8050-2018; Park, Jung/AAK-5167-2020; Kim, Gyeonghwa/AAQ-6424-2021 57195957884; 57214671308; 57191674344; 7004074582; 7004694832; 57194094753; 7404096216; 57216816399; 59142854300; 57907713300; 22953484700; 24764974400; 57202881977; 8861888000 magnolia1103@naver.com;KeunHur@knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.38 2025-07-30 5 7 ALPHA-FETOPROTEIN; CANCER; MICRORNA; GROWTH; ACTS Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; RNA, Circular; Survival Analysis; tumor marker; aged; cancer staging; down regulation; female; gene expression regulation; gene regulatory network; genetics; human; liver cell carcinoma; liver tumor; male; middle aged; pathology; prognosis; survival analysis English 2021 2021-07-22 10.1038/s41598-021-94074-y 바로가기 바로가기 바로가기 바로가기
Article Clinical application of the experimental ADL test for patients with cognitive impairment: pilot study We employed a hospital-based Internet of Things (IoT) platform to validate the role of real-time activities of daily living (ADL) measurement as a digital biomarker for cognitive impairment in a hospital setting. Observational study. 12 patients with dementia, 11 patients with mild cognitive impairment (MCI), and 15 cognitively normal older adults. The results of 13 experimental ADL tasks were categorized into success or fail. The total number of successful task and the average success proportion of each group was calculated. Time to complete the total tasks was also measured. Patients with dementia, patients with MCI, and cognitively normal older adults performed 13 experimental ADL tasks in a hospital setting. Significant differences in the average success rate of 13 tasks were found among groups. Dementia group showed the lowest success proportion (49.3%) compared with MCI group (78.3%) and normal group (97.4%). Correlation between classical ADL scales and the number of completed ADL tasks was statistically significant. In particular, instrumental ADL (I-ADL) had stronger relationship with the number of completed ADL tasks than Barthel's ADL (B-ADL). Dementia group required more time to accomplish the tasks when compared to MCI and normal groups. This study demonstrated that there is a clear relationship between the performance of experimental ADL tasks and the severity of cognitive impairment. The evaluation of ADLs involving the IoTs platform in an ecological setting allows accurate assessment and quantification of the patient's functional level. Lim, Yong-Hyun; Baek, Yookyeong; Kang, Soon Ju; Kang, Kyunghun; Lee, Ho-Won Kyungpook Natl Univ, Ctr Self Organizing Software Platform, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Coll IT Engn, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea 57202416711; 57221468229; 55666313900; 55365592200; 35337240700 neuromd@knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.32 2025-07-30 9 6 OLDER-ADULTS; SELF-CARE; DEMENTIA; MILD Activities of Daily Living; Aged; Aged, 80 and over; Case-Control Studies; Cognitive Dysfunction; Female; Geriatric Assessment; Humans; Male; Pilot Projects; aged; case control study; cognitive defect; daily life activity; female; geriatric assessment; human; male; pilot study; psychology; very elderly English 2021 2021-01-11 10.1038/s41598-020-78289-z 바로가기 바로가기 바로가기 바로가기
Article Comparative study of efficiency and characteristics of FMT and DRT installed in human cadavers for round-window stimulation Acoustic hearing aids generate amplified sound in the ear canal, and they are the standard of care for patients with mild to moderate sensorineural hearing loss. However, because of their limited frequency bandwidth, gain, and feedback, there is substantial room for improvement. Active middle ear implants, which directly vibrate the middle ear and cochlea, are an alternative approach to conventional acoustic hearing aids. They provide an opportunity to improve sound quality and speech understanding with amplification rehabilitation. For floating-mass type and direct-rod type (DRT) middle ear transducers, a differential floating-mass transducer (DFMT) and a tri-coil bellows transducer (TCBT), respectively, were fabricated to measure the output characteristics in four human temporal bones. Both were fabricated to have similar output forces per unit input and were placed in four human temporal bones to measure their output performances. The TCBT resulted in higher output than did the DFMT throughout the audible frequency range, and the output was more prominent at lower frequency ranges. In this study, we showed that DRT was a more effective method for round window stimulation. Because of its frequency characteristics and vibration efficiency, this implantation method can be utilized as a driving solution for middle ear implants. Shin, Dong Ho; Kim, Jong Hoon; Gottlieb, Peter; Vaisbuch, Yona; Puria, Sunil; Cho, Jin-Ho; Seong, Ki Woong Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41944, South Korea; Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA; Rambam Med Ctr, Otolaryngol Head & Neck Dept, IL-31096 Haifa, Israel; Kyungpook Natl Univ Hosp, Dept Biomed Engn, Daegu 41944, South Korea; Harvard Med Sch, Dept Otolaryngol Head & Neck Surg, Eaton Peabody Lab, Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA Puria, Sunil/CAI-6731-2022 56693502600; 57201854156; 56748717500; 54685418300; 6603522130; 57388235200; 23968197900 seongkw@ee.knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.05 2025-07-30 4 4 FLOATING MASS TRANSDUCER; MIDDLE-EAR IMPLANT; HEARING DEVICE; PERFORMANCE Acoustic Stimulation; Hearing Aids; Hearing Loss; Humans; Round Window, Ear; Temporal Bone; auditory stimulation; cochlea fenestra; hearing aid; hearing impairment; human; pathophysiology; temporal bone English 2021 2021-08-18 10.1038/s41598-021-95456-y 바로가기 바로가기 바로가기 바로가기
Article Comparison of ocular surface assessment and adherence between preserved and preservative-free latanoprost in glaucoma: a parallel-grouped randomized trial Given that nonadherence is related to subject characteristics and drug tolerance and preserved eye drops tend to be more intolerable than preservative-free ones, we conducted a phase 4, parallel-grouped, investigator-blind, active-control, randomized, multicenter study. A total of 51 patients with intraocular pressure (IOP)>= 15 mmHg diagnosed with open-angle glaucoma or ocular hypertension were randomly assigned to the preserved latanoprost group (n=26) and the preservative-free latanoprost group (n=25). The efficacy variables were corneal/conjunctival staining grade, Ocular Surface Disease Index (OSDI), adherence at 12 weeks after the first administration; corneal/conjunctival staining grade at 4 weeks; and IOP, tear break-up time (TBUT), and hyperemia score at 4 and 12 weeks. The safety variables included visual acuity and drug tolerance questionnaire results. There was no statistically significant difference in corneal/conjunctival staining grade, OSDI, or TBUT between the groups at 4 and 12 weeks. However, the adherence rate was higher and the hyperemia score was lower in the preservative-free group than in the preserved group. The severity and duration of stinging/burning sensation were lower in the preservative-free group than in the preserved group. Overall, preservative-free latanoprost showed better ocular tolerance assessed by hyperemia scores and stinging/burning symptoms following higher adherence than preserved latanoprost. Kim, Dai Woo; Shin, Jonghoon; Lee, Chang Kyu; Kim, Myungjin; Lee, Sohyeon; Rho, Seungsoo Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Pusan Natl Univ, Yangsan Hosp, Coll Med, Dept Ophthalmol, Yangsan, South Korea; Pusan Natl Univ Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Ophthalmol, Yangsan, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Ophthalmol, Ulsan, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Ophthalmol, 59 Yatap Ro, Seongnam Si 463712, Gyeonggi Do, South Korea ; Rho, Seungsoo/KCK-2120-2024 57095192800; 36912100400; 57196253397; 57226324767; 57226316496; 53865302800 harryrho@gmail.com; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.81 2025-07-30 11 17 BENZALKONIUM CHLORIDE; PROSTAGLANDIN ANALOGS; EFFICACY; EYEDROPS; SAFETY; HYPERTENSION; PREVALENCE; PATTERNS; CORNEAL; DISEASE Aged; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intention to Treat Analysis; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Preservatives, Pharmaceutical; Treatment Adherence and Compliance; Treatment Outcome; eye drops; latanoprost; preservative; aged; chemistry; clinical trial; comparative study; controlled study; drug administration; female; human; intention to treat analysis; intraocular hypertension; male; middle aged; multicenter study; open angle glaucoma; patient compliance; phase 4 clinical trial; randomized controlled trial; treatment outcome English 2021 2021-07-22 10.1038/s41598-021-94574-x 바로가기 바로가기 바로가기 바로가기
Article Comparison of three different types of exercises for selective contractions of supra- and infrahyoid muscles Several exercise methods, such as the Shaker exercise, tongue press exercise, chin tuck against resistance (CTAR) exercise, and submandibular push exercise, have been introduced to strengthen the muscles involved in swallowing. In this study, we compared the effectiveness of the CTAR, submandibular push, and Shaker exercises for the induction of selective supra- and infrahyoid muscle contractions using surface electromyography (EMG). This study is a prospective non-randomized controlled study. Twenty-five healthy subjects and 20 patients experiencing swallowing difficulty were enrolled. During the three different types of exercises, the root mean square (RMS) values of the sternocleidomastoid (SCM), suprahyoid (anterior belly of the digastric and mylohyoid muscles), and infrahyoid (sternothyroid and thyrohyoid muscles) muscles were analyzed using surface EMG. Differences in the activity of swallowing muscles among the three different exercises were analyzed using one-way repeated measured analysis of variance. In terms of both the maximum and mean RMS values of the suprahyoid muscle, the submandibular push exercise showed a larger RMS value than the CTAR and Shaker exercises in healthy subjects (p<0.05). In terms of both the maximum and mean RMS values of the suprahyoid muscle, the Shaker exercise and submandibular push exercise showed a larger RMS value than the CTAR exercise in patients with swallowing difficulty (p<0.05). The submandibular push exercise may be effective as a swallowing muscle exercise owing to its superiority in inducing selective contractions of the supra- and infrahyoid muscles. The CTAR and Shaker exercises are also effective in this regard. Chang, Min Cheol; Park, Sungwon; Cho, Joo Young; Lee, Byung Joo; Hwang, Jong-Moon; Kim, KwanMyung; Park, Donghwi Yeungnam Univ Hosp, Dept Rehabil Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Rehabil Med, Daegu, South Korea; Ulsan Natl Inst Sci & Technol, Grad Sch Creat Design Engn, Ulsan, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Phys Med & Rehabil, 877 Bangeojinsunhwando Ro, Ulsan 44033, South Korea CHO, JOO/AAJ-2012-2020; Park, Donghwi/GYQ-6185-2022; Chang, Min Cheol/AAE-2321-2022 23767019400; 57211828460; 57211083171; 57202436497; 56367634000; 55339231200; 56606561400 bdome@hanmail.net; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.76 2025-07-30 18 16 SURFACE ELECTRICAL-STIMULATION; CHIN TUCK; SWALLOWING REHABILITATION; RESISTANCE CTAR; HEAD LIFT; DYSPHAGIA; MOVEMENT Adult; Aged; Aged, 80 and over; Case-Control Studies; Deglutition; Deglutition Disorders; Exercise; Exercise Therapy; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Skeletal; Young Adult; adult; aged; case control study; clinical trial; comparative study; dysphagia; exercise; female; human; kinesiotherapy; male; middle aged; muscle contraction; physiology; procedures; skeletal muscle; swallowing; very elderly; young adult English 2021 2021-03-30 10.1038/s41598-021-86502-w 바로가기 바로가기 바로가기 바로가기
Article Conjugate buoyant convective transport of nanofluids in an enclosed annular geometry A vertical annular configuration with differently heated cylindrical surfaces and horizontal adiabatic boundaries is systematically studied in view to their industrial applications. In this paper, we investigate the effects of conjugate buoyant heat transport in water based nanofluids with different nanoparticles such as alumina, titania or copper, and is filled in the enclosed annular gap. The annulus space is formed by a thick inner cylinder having a uniform high temperature, an exterior cylindrical tube with a constant lower temperature, and thermally insulated upper and lower surfaces. By investigating heat transport for broad spectrum of Rayleigh number, solid wall thickness, thermal conductivity ratio and nanoparticle volume fraction, we found that the influence of wall thickness on thermal dissipation rate along wall and interface greatly depends on conductivity ratio and vice-versa. In particular, we uncover that the choice of nanoparticle in a nanofluid and its concentration are key factors in enhancing the thermal transport along the interface. Specially, copper based nanofluids produces higher heat transport among other nanoparticles, and for the range of nanoparticle concentration chosen in this analysis, enhanced thermal dissipation along the interface has been detected as nanoparticle volume fraction is increased. Our results are applicable to choose nanofluids along with other critical parameters for the desired heat transport. Sankar, M.; Reddy, N. Keerthi; Do, Younghae Univ Technol & Appl Sci Ibri, Dept Gen Requirements, Ibri 516, Oman; Presidency Univ, Sch Engn, Dept Math, Bengaluru 560064, India; Kyungpook Natl Univ, KNU Ctr Nonlinear Dynam, Dept Math, Daegu 41566, South Korea Do, Younghae/G-3522-2011; Reddy N., Keerthi/AAT-5305-2021; Mani, Sankar/AAT-5256-2021; , KEERTHI REDDY N/AAT-5305-2021 6701530391; 57218368327; 7103101109 yhdo@knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 1.62 2025-07-30 24 34 HEAT-TRANSFER ENHANCEMENT; POLY(VINYLIDENE FLUORIDE) MOLECULES; NATURAL-CONVECTION; SQUARE ENCLOSURE; VERTICAL ANNULUS; MAGNETIC-FIELD; CAVITY; RHEOLOGY; DRIVEN English 2021 2021-08-24 10.1038/s41598-021-96456-8 바로가기 바로가기 바로가기 바로가기
Article CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 normal, 50 emphysema, and 51 IPF subjects were included. A mass preserving image registration technique was used to compute displacement vectors of local lung regions at an acinar scale. Movement of the diaphragm was assumed to be equivalent to movement of the basal lung within 5 mm from the diaphragm. Magnitudes and directions of displacement vectors were compared between the groups. Three-dimensional (3D) and apico-basal displacements were smaller in emphysema than normal subjects (P = 0.003, P = 0.002). Low lung attenuation area on expiration scan showed significant correlations with decreased 3D and apico-basal displacements (r = - 0.546, P < 0.0001; r = - 0.521, P < 0.0001) in emphysema patients. Dorsal-ventral displacement was smaller in IPF than normal subjects (P < 0.0001). The standard deviation of the displacement angle was greater in both emphysema and IPF patients than normal subjects (P < 0.0001). In conclusion, apico-basal movement of the diaphragm is reduced in emphysema while dorsal-ventral movement is reduced in IPF. Image registration technique to multi-volume CT scans provides insight into the pathophysiology of limited diaphragmatic motion in emphysema and IPF. Kang, Ji Hee; Choi, Jiwoong; Chae, Kum Ju; Shin, Kyung Min; Lee, Chang-Hoon; Guo, Junfeng; Lin, Ching-Long; Hoffman, Eric A.; Lee, Changhyun Konkuk Univ, Dept Radiol, Med Ctr, Seoul, South Korea; Univ Kansas, Sch Med, Dept Internal Med, 3901 Rainbow Blvd, Kansas City, KS 66160 USA; Univ Kansas, Dept Bioengn, Lawrence, KS 66045 USA; Jeonbuk Natl Univ Hosp, Dept Radiol, Jeonju, South Korea; Kyungpook Natl Univ, Dept Radiol, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea; Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA; Univ Iowa, Roy J Carver Dept Biomed Engn, Iowa City, IA USA; Univ Iowa, Dept Mech Engn, IIHR Hydrosci & Engn, Iowa City, IA USA; Univ Iowa, Dept Med, Iowa City, IA 52242 USA; Seoul Natl Univ, Dept Radiol, Coll Med, 101 Daehangno, Seoul 03080, South Korea Guo, junfeng/LJK-3575-2024; Kim, Jong/J-2749-2012 57192688411; 55749525100; 57195310676; 7402410737; 56150043400; 55579979800; 8923593300; 58000586800; 57196253438 jchoi4@kumc.edu;changhyun.lee@snu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.49 2025-07-30 10 10 IDIOPATHIC PULMONARY-FIBROSIS; INTERSTITIAL LUNG-DISEASE; DIAPHRAGMATIC MOTION; FLOW LIMITATION; SYSTEM; REGISTRATION; FLUOROSCOPY; ULTRASOUND; THICKNESS; DIAGNOSIS Adult; Aged; Aged, 80 and over; Female; Healthy Volunteers; Humans; Idiopathic Pulmonary Fibrosis; Imaging, Three-Dimensional; Lung; Lung Volume Measurements; Male; Middle Aged; Pulmonary Emphysema; Tomography, X-Ray Computed; Young Adult; adult; aged; comparative study; diagnostic imaging; female; fibrosing alveolitis; human; lung; lung emphysema; lung volume; male; middle aged; normal human; procedures; three-dimensional imaging; very elderly; x-ray computed tomography; young adult English 2021 2021-07-21 10.1038/s41598-021-93980-5 바로가기 바로가기 바로가기 바로가기
Article Deep learning based prediction of extraction difficulty for mandibular third molars This paper proposes a convolutional neural network (CNN)-based deep learning model for predicting the difficulty of extracting a mandibular third molar using a panoramic radiographic image. The applied dataset includes a total of 1053 mandibular third molars from 600 preoperative panoramic radiographic images. The extraction difficulty was evaluated based on the consensus of three human observers using the Pederson difficulty score (PDS). The classification model used a ResNet-34 pretrained on the ImageNet dataset. The correlation between the PDS values determined by the proposed model and those measured by the experts was calculated. The prediction accuracies for C1 (depth), C2 (ramal relationship), and C3 (angulation) were 78.91%, 82.03%, and 90.23%, respectively. The results confirm that the proposed CNN-based deep learning model could be used to predict the difficulty of extracting a mandibular third molar using a panoramic radiographic image. Yoo, Jeong-Hun; Yeom, Han-Gyeol; Shin, WooSang; Yun, Jong Pil; Lee, Jong Hyun; Jeong, Seung Hyun; Lim, Hun Jun; Lee, Jun; Kim, Bong Chul Wonkwang Univ, Daejeon Dent Hosp, Coll Dent, Dept Oral & Maxillofacial Surg, Daejeon, South Korea; Wonkwang Univ, Daejeon Dent Hosp, Coll Dent, Dept Oral & Maxillofacial Radiol, Daejeon, South Korea; Korea Inst Ind Technol KITECH, Safety Syst Res Grp, Gyongsan, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu, South Korea ; Kim, Bong/ABB-3866-2020 57221727814; 57208645237; 57221727628; 16644164300; 57221622970; 57219224526; 56060726800; 55121680500; 55578739400 bck@wku.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 3.3 2025-07-30 69 76 SURGICAL DIFFICULTY Deep Learning; Humans; Mandible; Molar, Third; Tooth Extraction; article; consensus; convolutional neural network; deep learning; extraction; human; mandibular third molar; prediction; preoperative evaluation; residual neural network; mandible; procedures; surgery; third molar; tooth extraction English 2021 2021-01-21 10.1038/s41598-021-81449-4 바로가기 바로가기 바로가기 바로가기
Article Deep visual domain adaptation and semi-supervised segmentation for understanding wave elevation using wave flume video images Accurate water surface elevation estimation is essential for understanding nearshore processes, but it is still challenging due to limitations in measuring water level using in-situ acoustic sensors. This paper presents a vision-based water surface elevation estimation approach using multi-view datasets. Specifically, we propose a visual domain adaptation method to build a water level estimator in spite of a situation in which ocean wave height cannot be measured directly. We also implemented a semi-supervised approach to extract wave height information from long-term sequences of wave height observations with minimal supervision. We performed wave flume experiments in a hydraulic laboratory with two cameras with side and top viewpoints to validate the effectiveness of our approach. The performance of the proposed models were evaluated by comparing the estimated time series of water elevation with the ground-truth wave gauge data at three locations along the wave flume. The estimated time series were in good agreement within the averaged correlation coefficient of 0.98 and 0.90 on the measurement and 0.95 and 0.85 on the estimation for regular and irregular waves, respectively. Kim, Jinah; Kim, Taekyung; Oh, Sang-Ho; Do, Kideok; Ryu, Joon-Gyu; Kim, Jaeil Korea Inst Ocean Sci & Technol, Coastal Disaster Res Ctr, Busan 49111, South Korea; Changwon Natl Univ, Dept Civil Engn, Changwon Si 51140, South Korea; Korea Maritime & Ocean Univ, Dept Ocean Engn, Busan 49111, South Korea; Elect & Telecommun Res Inst, Satellite Wide Area Infra Res Sect, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea Do, Kideok/AHD-8394-2022; Oh, Sang Ho/ISV-3878-2023 55720345100; 59471665700; 57325168400; 36561293000; 7401868766; 57211615348 jaeilkim@knu.ac.kr; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 0.05 2025-07-30 0 1 English 2021 2021-11-05 10.1038/s41598-021-01157-x 바로가기 바로가기 바로가기 바로가기
Article Development of a deep learning-based software for calculating cleansing score in small bowel capsule endoscopy A standardized small bowel (SB) cleansing scale is currently not available. The aim of this study was to develop an automated calculation software for SB cleansing score using deep learning. Consecutively performed capsule endoscopy cases were enrolled from three hospitals. A 5-step scoring system based on mucosal visibility was trained for deep learning in the training set. Performance of the trained software was evaluated in the validation set. Average cleansing score (1.0 to 5.0) by deep learning was compared to clinical grading (A to C) reviewed by clinicians. Cleansing scores decreased as clinical grading worsened (scores of 4.1, 3.5, and 2.9 for grades A, B, and C, respectively, P<0.001). Adequate preparation was achieved for 91.7% of validation cases. The average cleansing score was significantly different between adequate and inadequate group (4.0 vs. 2.9, P<0.001). ROC curve analysis revealed that a cut-off value of cleansing score at 3.25 had an AUC of 0.977. Diagnostic yields for small, hard-to-find lesions were associated with high cleansing scores (4.3 vs. 3.8, P<0.001). We developed a novel scoring software which calculates objective, automated cleansing scores for SB preparation. The cut-off value we suggested provides a standard criterion for adequate bowel preparation as a quality indicator. Nam, Ji Hyung; Hwang, Youngbae; Oh, Dong Jun; Park, Junseok; Kim, Ki Bae; Jung, Min Kyu; Lim, Yun Jeong Dongguk Univ, Coll Med, Ilsan Hosp, Div Gastroenterol,Dept Internal Med, Goyang, South Korea; Chungbuk Natl Univ, Dept Elect Engn, Cheongju, South Korea; Soonchunhyang Univ, Coll Med, Inst Digest Res, Dept Internal Med,Digest Dis Ctr, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Daegu, South Korea Kim, Ki Bae/KYQ-0127-2024; Park, Junseok/ABS-0095-2022 42361607200; 7402311392; 57203029221; 57201131480; 56106965700; 56783168100; 56501161800 drlimyj@gmail.com; SCIENTIFIC REPORTS SCI REP-UK 2045-2322 11 1 SCIE MULTIDISCIPLINARY SCIENCES 2021 4.997 25.0 1.51 2025-07-30 26 32 GRADING SYSTEM; QUALITY; VALIDATION Adolescent; Adult; Aged; Aged, 80 and over; Capsule Endoscopy; Colonoscopy; Deep Learning; Female; Humans; Intestine, Small; Male; Middle Aged; ROC Curve; Software; Young Adult; adolescent; adult; aged; capsule endoscopy; colonoscopy; diagnostic imaging; female; human; male; middle aged; procedures; receiver operating characteristic; small intestine; software; very elderly; young adult English 2021 2021-02-24 10.1038/s41598-021-81686-7 바로가기 바로가기 바로가기 바로가기
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KeywordsPlus (WoS) Web of Science에서 자동으로 추출한 추가 키워드입니다. 논문의 참고문헌 제목에서 자주 등장하는 단어들로 생성됩니다.
Keywords (SCOPUS) 저자가 논문에서 직접 지정한 키워드입니다. SCOPUS에 등록된 저자 키워드 목록입니다.
KeywordsPlus (SCOPUS) SCOPUS에서 자동으로 추출하거나 추가한 색인 키워드입니다.
Language 논문이 작성된 언어입니다. 대부분 English이며, 그 외 다양한 언어로 작성된 논문이 포함될 수 있습니다.
Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.