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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Significant Gap Between Guidelines and Practice in the Management of LDL Cholesterol: Insight From the Survey of the Korean Society of Myocardial Infarction | The Guidelines of the 2019 European Society of Cardiology (ESC) and the 5th Society of Lipid and Atherosclerosis (KSoLA) for the Management of Dyslipidemia advocate a more intensive lipid-lowering strategy. However, there is a lack of evidence regarding the current status of lipid management in Korean patients in real-world practice. The Korean Society of Myocardial Infarction conducted a survey among its members of the Korean Society of Cardiology on the new lipid guidelines. Although most participants were aware of the changes in the ESC and the KSoLA guidelines, more than half of them did not agree with lowering the low-density lipoprotein cholesterol levels to < 55 mg/dL, because its safety and efficacy have not yet been proven in Koreans. A substantial disparity exists between lipid management guidelines and current clinical practices, highlighting the necessity for clinical research that specifically targets East Asians and Koreans to bridge this gap. | Lee, Sang Yeub; Cho, Kyung Hoon; Lee, Jang Hoon; Hong, Young Joon; Hwang, Jin yong; Jeong, Myung Ho; Kim, Weon | Chung Ang Univ, Div Cardiol, Gwangmyeong Hosp, Gwangmyeong, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Cardiol, Gwangju, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Gyeongsang Natl Univ & Hosp, Coll Med, Dept Internal Med, Jinju 52727, South Korea; Kyung Hee Univ Hosp, Dept Cardiovasc Med, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Cardiovasc Med, 23 Kyungheedae Ro, Seoul 02447, South Korea | Jeong, Young-Hoon/F-3476-2015; Hong, Young Joon/A-2792-2011; Lee, Sang Yeub/AEQ-6658-2022; Kim, Jwa/AAH-9915-2021 | 35187345000; 55595842500; 54581258000; 13310329100; 55892914700; 56485157500; 8570166100 | mylovekw@hanmail.net; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 50 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 2 | 2 | Dyslipidemias; Myocardial Infarction; Cholesterol; Low-density Lipoprotein Cholesterol | Cholesterol; Dyslipidemias; Low-density Lipoprotein Cholesterol; Myocardial Infarction | Atherosclerosis; Cholesterol, LDL; Dyslipidemias; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Republic of Korea; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; atherosclerosis; dyslipidemia; heart infarction; human; South Korea | English | 2023 | 2023-12-25 | 10.3346/jkms.2023.38.e419 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Small Bowel Capsule Endoscopy within 6 Hours following Bowel Preparation with Polyethylene Glycol Shows Improved Small Bowel Visibility | Although bowel preparation influences small bowel visibility for small bowel capsule endoscopy (SBCE), the optimal timing for bowel preparation has not been established yet. Thus, the aim of the study was to evaluate the optimal timing of polyethylene glycol (PEG) for small bowel preparation before SBCE. This multicenter prospective observational study was conducted on patients who underwent SBCE following bowel preparation with polyethylene glycol (PEG). Patients were categorized into three groups according to the time used for completing PEG ingestion: group A, within 6 h; group B, 6-12 h; and group C, over 12 h. The percentage of unclean segment in small bowel (unclean image duration / small bowel transit time x 100) and small bowel visibility quality (SBVQ) were evaluated according to the time interval between the last ingestion of PEG and swallowing of small bowel capsule endoscope. A total of 90 patients were enrolled and categorized into group A (n = 40), group B (n = 27), and group C (n = 23). The percentage of unclean segment in the entire small bowel increased gradually from group A to C (6.6 +/- 7.6% in group A, 11.3 +/- 11.8% in group B, and 16.2 +/- 10.7% in group C, p = 0.001), especially in the distal small bowel (11.4 +/- 13.6% in group A, 20.7 +/- 18.7% in group B, and 29.5 +/- 16.4% in group C, p < 0.001). The proportion of patients with adequate SBVQ in group A was significantly (p < 0.001) higher (30/40, 75.0%) than that in group B (17/27, 63.0%) or group C (5/23, 21.7%). In multivariate analysis, group A was associated with an increased likelihood of adequate SBVQ compared with group C (odds ratio [OR]: 13.05; 95% confidence interval [CI]: 3.53-48.30, p < 0.001). Completing PEG ingestion within 6 h prior to SBCE could enhance small bowel visibility. | Choi, Chang Wan; Lee, So Jung; Hong, Sung Noh; Kim, Eun Ran; Chang, Dong Kyung; Kim, Young-Ho; Lim, Yun Jeong; Shim, Ki-Nam; Lee, Hyun-Seok | Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul 60351, South Korea; Dongguk Univ, Sch Med, Ilsan Hosp, Dept Internal Med, Goyang 10326, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul 07804, South Korea; Kyungpook Natl Univ, Med Ctr, Sch Med, Dept Internal Med, Daegu 37224, South Korea | LIM, Yun Jeong/KVY-6446-2024; Kim, Eun Ran/AAD-8003-2022; Hong, Sung Noh/MTB-0511-2025 | 58099720700; 58099861300; 57220761219; 56402163800; 7403319864; 57210738018; 56501161800; 13604838300; 36647886100 | gisnhong@gmail.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 13 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.76 | 2025-06-25 | 6 | 4 | small bowel capsule endoscopy; bowel preparation; polyethylene glycol; small bowel visibility quality | QUALITY; METAANALYSIS; COLONOSCOPY; SIMETHICONE; SOCIETY; DIET | bowel preparation; polyethylene glycol; small bowel capsule endoscopy; small bowel visibility quality | acetylsalicylic acid; anticoagulant agent; antithrombocytic agent; macrogol; nonsteroid antiinflammatory agent; adult; Article; capsule endoscopy; confidence interval; female; human; intestine preparation; major clinical study; male; middle aged; observational study; odds ratio; prospective study; small intestine; swallowing | English | 2023 | 2023-02 | 10.3390/diagnostics13030469 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Survey-Based Analysis of the Clinical Treatment Status of Irritable Bowel Syndrome in Korea | Background: The quality-of-life of patients with irritable bowel syndrome is low; incorrect diagnosis/treatment causes economic burden and inappropriate consumption of medical resources. This survey-based study aimed to analyze the current status of irritable bowel syndrome treatment to examine differences in doctors' perceptions of the disease, and treatment patterns.Methods: From October 2019 to February 2020, the irritable bowel syndrome and Intestinal Function Research Study Group of the Korean Society of Neurogastroenterology and Motility conducted a survey on doctors working in primary, secondary, and tertiary healthcare institutions. The questionnaire included 37 items and was completed anonymously using the NAVER platform (a web-based platform), e-mails, and written forms.Results: A total of 272 doctors responded; respondents reported using the Rome IV diagnostic criteria (amended in 2016) for diagnosing and treating irritable bowel syndrome. Several differences were noted between the primary, secondary, and tertiary physicians' groups. The rate of colonoscopy was high in tertiary healthcare institutions. During a colonoscopy, the necessity of random biopsy was higher among physicians who worked at tertiary institutions. 'The patient did not adhere to the diet' as a reason for ineffectiveness using low-fermentable oligo-, di-, and mono-saccharides, and polyols diet treatment was higher among physicians in primary/secondary institutions, and 'There are individual differences in terms of effectiveness' was higher among physicians in tertiary institutions. In irritable bowel syndrome constipation predominant subtype, the use of serotonin type 3 receptor antagonist (ramosetron) and probiotics was higher in primary/secondary institutions, while serotonin type 4 receptor agonist was used more in tertiary institutions. In irritable bowel syndrome diarrhea predominant subtype, the use of antispasmodics was higher in primary/secondary institutions, while the use of serotonin type 3 receptor antagonist (ramosetron) was higher in tertiary institutions.Conclusion: Notable differences were observed between physicians in primary/secondary and tertiary institiutions regarding the rate of colonoscopy, necessity of random biopsy, the reason for the ineffectiveness of low-fermentable oligo-, di-, and mono-saccharides, and polyols diet, and use of drug therapy in irritable bowel syndrome. In South Korea, irritable bowel syndrome is diagnosed and treated according to the Rome IV diagnostic criteria, revised in 2016. | Koo, Hoon Sup; Son, Hui Chang; Lee, Hong Sub; Goong, Hyeon Jeong; Kim, Ju Seok; Kim, Ki Bae; Kwon, Yong Hwan; Kim, Jae Hak; Shin, Hyun Deok; Shin, Ji Eun; Jee, Sam Ryong | Konyang Univ Hosp, Dept Internal Med, Daejeon, South Korea; Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea; Soonchunhyang Univ Hosp, Dept Internal Med, Bucheon, South Korea; Chungnam Natl Univ, Sch Med, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Dept Internal Med, Coll Med, Goyang, South Korea; Dankook Univ, Dept Internal Med, Coll Med, Cheonan, South Korea; Konyang Univ, Coll Med, Dept Biomed Informat, Daejeon, South Korea | Kim, Ki Bae/KYQ-0127-2024; LEE, HONG SUB/E-1572-2014 | 58209332900; 58198263500; 42761539900; 55395309400; 56670596700; 56106965700; 55775556800; 50161761100; 35337953500; 57204168800; 14621389400 | tokimom@nate.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.51 | 2025-06-25 | 2 | 2 | Irritable Bowel Syndrome; Diagnosis; Treatment; Rome IV Diagnostic Criteria | PRACTICE GUIDELINES; ASIAN CONSENSUS; CONSTIPATION; MECHANISMS; EFFICACY; PRUCALOPRIDE; PREVALENCE; MANAGEMENT; PROBIOTICS; RIFAXIMIN | Diagnosis; Irritable Bowel Syndrome; Rome IV Diagnostic Criteria; Treatment | Constipation; Diarrhea; Humans; Irritable Bowel Syndrome; Serotonin; Surveys and Questionnaires; serotonin; constipation; diarrhea; human; irritable colon; questionnaire | English | 2023 | 2023-04-24 | 10.3346/jkms.2023.38.e126 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Multifaceted Clinical Characteristics of Congenital Cytomegalovirus Infection: From Pregnancy to Long-Term Outcomes | Background: The aim of this study was to capture multifaceted clinical characteristics of congenital cytomegalovirus (CMV) infection from diagnosis to treatment using a multidisciplinary approach including obstetrics, pediatrics, pathology, and otorhinolaryngology-head and neck surgery. Methods: This is a retrospective study including 30 consecutive cases of congenital CMV infection that were diagnosed at a single tertiary hospital located in Seoul, Korea from January 2009 to December 2020. Congenital CMV infection was defined as a positive result by polymerase chain reaction from urine, saliva or cerebrospinal fluid or positive CMV IgM from neonatal blood sampled within 3 weeks after birth. All cases were analyzed with respect to whole clinical characteristics from diagnosis to treatment of congenital CMV by a multidisciplinary approach including prenatal sonographic findings, maternal immune status regarding CMV infection, detailed placental pathology, neonatal clinical manifestation, auditory brainstem response test, and antiviral treatment (ganciclovir or valganciclovir). Long-term outcomes including developmental delay and hearing loss were also investigated. Results: The total number of births during the study period in our institution was 19,385, with the prevalence of congenital infection estimated to be 0.15%. Among 30 cases of congenital CMV, the median gestational age at delivery was 32.2 weeks [range, 22.6-40.0] and 66.7% of these infants were delivered preterm at less than 37 weeks. Suspected fetal growth restriction was the most common prenatal ultrasound finding (50%) followed by ventriculomegaly (17.9%) and abnormal placenta (17.9%), defined as thick placenta with calcification. No abnormal findings on ultrasound examination were observed in one-third of births. Maternal CMV serology tests were conducted in only 8 cases, and one case each of positive and equivocal IgM were found. The most common placental pathologic findings were chronic villitis (66.7%) and calcification (63.0%), whereas viral inclusions were identified in only 22.2%. The most common neonatal manifestations were jaundice (58.6%) followed by elevation of aspartate aminotransferase (55.2%) and thrombocytopenia (51.7%). After excluding cases for which long-term outcomes were unavailable due to death (n = 4) or subsequent follow up loss (n = 3), developmental delay was confirmed in 43.5% of infants (10/23), and hearing loss was confirmed in 42.9% (9/21) during the follow-up period. In our cohort, 56.7% (17/30) of neonates were treated for congenital CMV with ganciclovir or valganciclovir. Conclusion: Our data show that prenatal findings including maternal serologic tests and ultrasound have limited ability to detect congenital CMV in Korea. Given that CMV is associated with high rates of developmental delay and hearing loss in infants, there is an urgent need to develop specific strategies for the definite diagnosis of congenital CMV infection during the perinatal period by a multidisciplinary approach to decrease the risks of neurologic impairment and hearing loss through early antiviral treatment. | Kim, Yejin; Kim, Yoo-min; Kim, Doo Ri; Kim, Han Gyeol; Sung, Ji-Hee; Choi, Suk-Joo; Oh, Soo-young; Kim, Yae-Jean; Chang, Yun Sil; Kim, Dongsub; Kim, Jung -Sun; Moon, Il Joon; Roh, Cheong-Rae | Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol, 81 Irwon Ro,Gangnam Gu, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro,Gangnam Gu, Seoul 06351, South Korea | Kim, Jung/JAO-0332-2023; Kim, Junetae/AAS-1234-2021; Doori, Kim/HPC-3877-2023; Kim, Yoo-min/AAZ-6413-2020 | 57268579600; 57191974142; 57217148489; 57210998391; 56347330000; 55601869400; 55601514300; 7410198066; 14041061300; 57205248455; 55863482600; 13606798300; 7003492919 | ohsymd@skku.edu;yaejeankim@skku.edu; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 32 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 2 | 1 | Cytomegalovirus; Congenital Infection; Infection Ultrasound; Ganciclovir; Valganciclovir; Developmental Delay; Hearing Loss | VALACICLOVIR; DIAGNOSIS | Congenital Infection; Cytomegalovirus; Developmental Delay; Ganciclovir; Hearing Loss; Infection Ultrasound; Valganciclovir | Antiviral Agents; Child; Cytomegalovirus Infections; Female; Fetal Growth Retardation; Ganciclovir; Hearing Loss; Humans; Immunoglobulin M; Infant; Infant, Newborn; Parturition; Placenta; Pregnancy; Retrospective Studies; Valganciclovir; antivirus agent; ganciclovir; immunoglobulin M; valganciclovir; birth; child; complication; cytomegalovirus infection; female; hearing impairment; human; infant; intrauterine growth retardation; newborn; placenta; pregnancy; retrospective study | English | 2023 | 2023-08-14 | 10.3346/jkms.2023.38.e249 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Relationship Between Childhood Trauma Experience and Complicated Grief: The Importance of Psychological Support for Individuals Coping With Pet Loss in Korea | Background: Loss of companion animals can result in various psychological reactions, including complicated grief, depression, anxiety, and insomnia. However, research on the prevalence of patients requiring clinical intervention is limited. Moreover, research examining the relationship between childhood trauma and psychological symptoms after pet loss is lacking. Therefore, this study aimed to investigate the rates of clinically significant psychological distress after pet loss and the impact of childhood trauma on adults who have experienced pet loss. Methods: An online survey was conducted with non-clinical adult participants who had experienced the loss of a companion animal. Psychiatric characteristics were evaluated using standardized assessments, including the Inventory of Complicated Grief (ICG), the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), and the Insomnia Severity Index (ISI). Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Results: In a sample of 137 individuals who had experienced pet loss, the percentages of those who exceeded the cutoff points were 55% for the ICG, 52% for the PHQ-9, 40% for the GAD-7, and 32% for the ISI. The group that reported childhood trauma exhibited significantly higher scores on the ICG (t = 2.16, P = 0.032), PHQ-9 (t = 3.05, P = 0.003), GAD-7 (t = 2.61, P = 0.010), and ISI (t = 2.11, P = 0.037) than in the group without childhood trauma. For participants who experienced pet loss for less than one year, there was no significant difference in the ICG between the trauma and non-trauma groups, as both had extremely high scores. However, the trauma group had a significantly higher PHQ-9 (t = 2.58, P = 0.012) than the non-trauma group. In contrast, for participants who experienced pet loss for more than one year, the trauma group had a significantly higher ICG (t = 2.22, P = 0.03) than the non-trauma group, while there was no significant difference in the PHQ-9. Additionally, the emotional abuse scores on the CTQ were most significantly correlated with the ICG scores even after controlling for depressive symptoms. Conclusion: People who experienced pet loss had significant psychological symptoms, ranging from 32% to 55%. Childhood trauma experiences affect complicated grief, depressive symptoms, anxiety symptoms, insomnia and prolonged grief disorder after pet loss. After pet loss, people with childhood trauma may require more psychological help than those without trauma. | Ahn, Jisung; Lee, Sang Won; Kim, Kyungmin; Jin, Bohyun; Chung, Un Sun | Kyungpook Natl Univ, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Dept Psychiat, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Dept Psychiat, Childrens Hosp, Daegu, South Korea; Kyungpook Natl Univ, Childrens Hosp, Sch Med, Dept Psychiat, 807 Hoguk Ro, Daegu 41404, South Korea | 58608306300; 55820414800; 57201480192; 57794813600; 24477437300 | unsunchung@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 37 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.26 | 2025-06-25 | 1 | 1 | Pet Loss; Psychological Support; Childhood Trauma; Complicated Grief; Korea | GENERALIZED ANXIETY DISORDER; GENDER-DIFFERENCES; LIFE STRESS; VALIDATION; VERSION; DEPRESSION; OWNERS; SENSITIZATION; COMORBIDITY; POPULATION | Childhood Trauma; Complicated Grief; Korea; Pet Loss; Psychological Support | Adaptation, Psychological; Adverse Childhood Experiences; Animals; Prolonged Grief Disorder; Republic of Korea; Sleep Initiation and Maintenance Disorders; animal; childhood adversity; complicated grief; insomnia; psychological adjustment; South Korea | English | 2023 | 2023-08-10 | 10.3346/jkms.2023.38.e305 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst: A Review of Technical Issues and Potential as a New Standard Treatment | The thyroglossal duct cyst (TGDC) is the most common congenital neck mass, accounting for 70-75% of all congenital neck masses. Although the Sistrunk operation has been used as a standard of treatment, it is accompanied by a considerable surgical burden, including the need for general anesthesia, a visible surgical scar on the neck surface, and postoperative complications. Ultrasound-guided ethanol ablation (US-EA) is a minimally invasive and office-based technique that is widely used as a non-surgical treatment for several benign cystic lesions, particularly benign thyroid cysts. Recently, US-EA has also been gaining popularity as a good alternative for TGDC treatment, which is associated with high feasibility, a high safety profile, and favorable treatment outcomes. To our best knowledge, seven studies on the use of EA as a primary treatment option for TGDC have been published since 2011. Although these studies have reported promising results, there is a lack of consensus on several issues regarding the application of EA for TGDC, particularly its detailed techniques and role as a primary treatment. This article aims to provide a comprehensive review of EA for TGDC, addressing technical issues and its possible role as a new standard of treatment for TGDC. | Ahn, Dongbin | Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 130 Dongdeok ro, Daegu 41944, South Korea | 44761055400 | godlikeu@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 17 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.24 | 2025-06-25 | 0 | 2 | thyroglossal duct cyst; ultrasound; ethanol; ablation; Sistrunk; sclerotherapy | EFFICACY; CARCINOMA; NODULES; SAFETY | ablation; ethanol; sclerotherapy; Sistrunk; thyroglossal duct cyst; ultrasound | alcohol; ablation therapy; aspiration; clinical effectiveness; clinical outcome; cost effectiveness analysis; health care cost; human; interventional ultrasonography; local anesthesia; patient assessment; Review; thyroglossal duct cyst; ultrasound guided ethanol ablation | English | 2023 | 2023-09 | 10.3390/jcm12175445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Use of Antibiotics Within the Last 14 Days of Life in Korean Patients: A Nationwide Study | Background: Antimicrobial prescriptions for serious chronic or acute illness nearing its end stages raise concerns about the potential for futile use, adverse events, increased multidrug-resistant organisms, and significant patient and social cost burdens. This study investigated the nationwide situation of how antibiotics are prescribed to patients during the last 14 days of life to guide future actions. Methods: This nationwide multicenter retrospective cohort study was conducted at 13 hospitals in South Korea from November 1 to December 31, 2018. All decedents were included in the study. Antibiotic use during the last two weeks of their lives was investigated. Results: A total of 1,201 (88.9%) patients received a median of two antimicrobial agents during the last two weeks of their lives. Carbapenems were prescribed to approximately half of the patients (44.4%) in the highest amount (301.2 days of therapy per 1,000 patient-days). Among the patients receiving antimicrobial agents, 63.6% were inappropriate and only 327 patients (27.2%) were referred by infectious disease specialists. The use of carbapenem (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.13-2.03; P = 0.006), underlying cancer (OR, 1.56; 95% CI, 1.20-2.01, P = 0.047), underlying cerebrovascular disease (OR, 1.88; 95% CI, 1.23-2.89, P = 0.004), and no microbiological testing (OR, 1.79; 95% CI, 1.15-2.73; P = 0.010) were independent predictors for inappropriate antibiotic prescribing. Conclusion: A considerable number of antimicrobial agents are administered to patients with chronic or acute illnesses nearing their end-of-life, a high proportion of which are prescribed inappropriately. Consultation with an infectious disease specialist, in addition to an antimicrobial stewardship program, may be necessary to induce the optimal use of antibiotics. | Wi, Yu Mi; Kwon, Ki Tae; Hwang, Soyoon; Bae, Sohyun; Kim, Yoonjung; Chang, Hyun-Ha; Kim, Shin -Woo; Cheong, Hae Suk; Lee, Shinwon; Jung, Dong Sik; Sohn, Kyung Mok; Moon, Chisook; Heo, Sang Taek; Kim, Bongyoung; Lee, Mi Suk; Hur, Jian; Kim, Jieun; Yoon, Young Kyung; Korean Society Antimicrobial Therapy | Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Internal Med, Sch Med, Chang Won, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Internal Med, Pusan, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Pusan, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Pusan, South Korea; Chungnam Natl Univ, Sch Med, Dept Internal Med, Daejeon, South Korea; Inje Univ, Dept Internal Med, Div Infect Dis, Coll Med, Busan, South Korea; Jeju Natl Univ, Coll Med, Dept Internal Med, Div Infect Dis, Jeju, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Yeungnam Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Infect Dis, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | ; Kim, Tae-You/J-2750-2012; Kim, Hanjin/KYP-2633-2024; Hwang, Soyoon/HHM-5762-2022; Kyung, Yoon/AAS-3428-2020; Kim, Sun/G-3451-2013; Kim, Woo/AAG-1822-2019; Jung, Dong Sik/HOH-5826-2023 | 23013143100; 9733850500; 57203160675; 57219699506; 57203160508; 7407521688; 57189703358; 57233155100; 24479446100; 14023089600; 16310477200; 22980995800; 9737963500; 55622077200; 55759244100; 19934047300; 51963871600; 25947937900 | ktkwon@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 38 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 2.81 | 2025-06-25 | 11 | 11 | Terminally Ill; Antimicrobial Agents; Carbapenem; Inappropriate; Antimicrobial Stewardship Programs | ANTIMICROBIAL USE; CARBAPENEM RESISTANCE; STEWARDSHIP PROGRAM; END; DEMENTIA; COMFORT; CARE; PNEUMONIA | Antimicrobial Agents; Antimicrobial Stewardship Programs; Carbapenem; Inappropriate; Terminally Ill | Anti-Bacterial Agents; Carbapenems; Communicable Diseases; Humans; Republic of Korea; Retrospective Studies; antiinfective agent; carbapenem derivative; clinical trial; communicable disease; human; multicenter study; retrospective study; South Korea | English | 2023 | 2023-03-06 | 10.3346/jkms.2023.38.e66 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Waist Circumference and Cardiovascular Risk Profiles after Autologous Breast Reconstruction: A Nationwide Population-Based Cohort Study | To date, few studies have examined changes in waist circumference and cardiovascular risk profile (CVRP) after autologous breast reconstruction. Therefore, this study aimed to investigate the effect of flap surgery using autologous tissue on waist circumference and CVRP through a nationwide population-based cohort study. In total, 6926 patients who underwent autologous breast reconstruction between 2015 and 2019 were considered. Of them, we evaluated 3444 patients who underwent the complete Korean National Health Insurance Service Health Screening (NHIS-HealS) before and after surgery. Body measurements, including waist circumference, weight, and body mass index; and CVRP, including blood pressure, fasting blood glucose, and cholesterol levels, were analyzed by type of surgery up to 3-4 years postoperatively. The body measurements of patients who underwent abdominal-based breast reconstruction were reduced 1-2 years after surgery, but returned to preoperative values 3-4 years after surgery. Regardless of the type of surgery, CVRP was worsened at both 1-2 years and 3-4 years after surgery, except for low-density lipoprotein values. Autologous breast reconstruction did not ameliorate the deterioration of CVRP over time. In addition, the abdominoplasty effect of abdominal-based breast reconstruction disappeared 1-2 years after surgery. | Ryu, Jeong Yeop; Kang, Myeong Jae; Cho, Hyun Geun; Yang, Jung Dug; Lee, Joon Seok | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Plast & Reconstruct Surg, 807 Hoguk ro, Daegu 41404, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022; LEE, JIN/Q-3108-2018; Yang, Jung/R-7806-2019 | 56366349400; 57445997600; 57211205767; 55171704700; 56496041000 | leejspo@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0.77 | 2025-06-25 | 3 | 3 | autologous breast reconstruction; abdominoplasty; waist circumference; cardiovascular risk profile | VASCULAR INFLAMMATORY MARKERS; QUALITY-OF-LIFE; INSULIN-RESISTANCE; LIPOSUCTION | abdominoplasty; autologous breast reconstruction; cardiovascular risk profile; waist circumference | cholesterol; glucose; low density lipoprotein; low density lipoprotein cholesterol; triacylglycerol; abdominoplasty; adolescent; adult; aged; anthropometry; Article; blood pressure; body mass; body weight; breast cancer; breast reconstruction; cardiovascular risk; child; cholesterol level; clinical evaluation; cohort analysis; deep inferior epigastric perforator flap; deterioration; fasting blood glucose level; female; follow up; human; latissimus dorsi flap; low density lipoprotein cholesterol level; major clinical study; male; middle aged; population research; postoperative period; preoperative evaluation; surgical technique; tissue flap; total cholesterol level; transverse rectus abdominis musculocutaneous flap; triacylglycerol blood level; waist circumference; young adult | English | 2023 | 2023-04 | 10.3390/jcm12083040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | XEN Gel Stent for Conjunctiva with Minimal Mobility Caused by Scleral Encircling: A Case Report | This case report describes the successful use of a XEN gel stent for controlling intraocular pressure (IOP) in a patient who had previously undergone scleral encircling for rhegmatogenous retinal detachment. The patient had very limited mobile conjunctiva due to scarring caused by the earlier surgery, which limited their options for glaucoma surgery. The XEN gel stent, a minimally invasive glaucoma surgery (MIGS) procedure that does not require opening the conjunctiva, was implanted in the subconjunctival space using an ab interno approach. Postoperative blebs were imaged using anterior segment optical coherence tomography, and IOP was monitored over six months. This study found that the XEN gel stent effectively controlled the IOP, and there were no complications during or after surgery. This case report may expand the indication for the XEN gel stent, which could be considered a viable option for patients who have undergone scleral buckling and have limited mobile conjunctiva. | Kim, Yuri; Kim, Myungjin; Kim, Dai Woo; Rho, Seungsoo | CHA Univ, Bundang CHA Med Ctr, Dept Ophthalmol, Seongnam 13496, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | Rho, Seungsoo/KCK-2120-2024; Gim, Yuri/JNZ-3445-2023 | 57454549500; 57226324767; 57095192800; 53865302800 | kimyuri0550@gmail.com;brandmjeyes@gmail.com;proector97@gmail.com;harryrho@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 12 | 13 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 3 | 17.8 | 0 | 2025-06-25 | 0 | 0 | MIGS; XEN gel stent; scleral buckling; blebs | IMPLANTATION; GLAUCOMA | blebs; MIGS; scleral buckling; XEN gel stent | bimatoprost; brimonidine; dorzolamide; dorzolamide plus timolol; epinephrine; latanoprost; lidocaine; moxifloxacin; mydriatic agent; prednisolone; timolol; adult; Article; best corrected visual acuity; case report; clinical article; conjunctiva; female; glaucoma; glaucoma surgery; human; intraocular pressure; middle aged; optical coherence tomography; postoperative complication; postoperative period; retina detachment; sclera buckling procedure; surgical technique; trabeculectomy; visual field | English | 2023 | 2023-07 | 10.3390/jcm12134293 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of insulin-like growth factor-1 on the proliferation and apoptosis of stallion testicular cells under normal and heat stress culture conditions | This study investigated the effect of heat stress on stallion testicular cells (TCs) and the effect of insulin-like growth factor (IGF)-1 on TC viability, proliferation, and apoptosis, including different stages of germ cells. TCs were divided into control or treatment groups with 0.01, 0.1, 1, 10, and 100 ng/mL of recombinant human IGF-1 (rhIGF-1) for 24 h at 34 degrees C and 37 degrees C. The population and viability were measured before and after treatment. The effects of rhIGF-1 on TC viability, proliferation, and apoptosis were determined using RT-qPCR. Proliferating cell nuclear antigen (PCNA) and marker of proliferation Ki-67 (MKI-67) were used as proliferation markers. Myeloid leukemia-1 (MCL-1) was used as an antiapoptotic marker. BCL2 antagonist/killer-1 (BAK-1) was used as a proapoptotic marker. The relative abundance of mRNA transcript of undifferentiated cell transcription factor 1 (UTF-1), protein gene product 9.5 (PGP9.5), and deleted in azoospermia-like (DAZL), was measured for spermatogenesis progression. TCs treated with 1 ng/mL rhIGF-1 at 34 degrees C exhibited the highest viability. Significant upregulation of the relative abundance of mRNA transcript of PCNA, MKI-67, and MCL-1 was observed in treated TCs compared with untreated TCs; however, BAK-1 was significantly downregulated in treated TCs. Germ cells treated with 1 ng/mL rhIGF-1 exhibited the highest relative abundance of mRNA transcript of UTF-1 and DAZL, whereas TCs exposed to 0.1 ng/mL showed the highest PGP9.5 level. These data confirm that heat stress in stallions decreases TC viability. These findings may help identify a basal IGF-1 level for TC proliferation and apoptosis during heat stress-induced testicular degeneration in stallions. | Shakeel, Muhammad; Yoon, Minjung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Sangju 37224, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Clin Studies, Rawalpindi 44000, Pakistan | 57209179360; 22137296500 | mjyoon@knu.ac.kr; | ANIMAL REPRODUCTION SCIENCE | ANIM REPROD SCI | 0378-4320 | 1873-2232 | 256 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;REPRODUCTIVE BIOLOGY;VETERINARY SCIENCES | 2023 | 2.2 | 18.1 | 1.31 | 2025-06-25 | 5 | 5 | Spermatogenesis; Germ cell viability; Testicular degeneration; Germ cells molecular markers | SPERMATOGONIAL STEM-CELLS; SCROTAL SURFACE-TEMPERATURE; ORGAN-CULTURE; SELF-RENEWAL; IGF-I; MOUSE; TESTIS; DIFFERENTIATION; TESTOSTERONE; LOCALIZATION | Germ cell viability; Germ cells molecular markers; Spermatogenesis; Testicular degeneration | Animals; Apoptosis; Cell Proliferation; Heat-Shock Response; Horses; Humans; Insulin-Like Growth Factor I; Male; Myeloid Cell Leukemia Sequence 1 Protein; Proliferating Cell Nuclear Antigen; Recombinant Proteins; RNA, Messenger; cycline; messenger RNA; protein mcl 1; recombinant protein; somatomedin C; animal; apoptosis; cell proliferation; genetics; heat shock response; horse; human; male; metabolism; physiology | English | 2023 | 2023-09 | 10.1016/j.anireprosci.2023.107319 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ultralow Fe instigated defect engineering of hierarchical N-Porous carbon for highly efficient electrocatalysis | Multifunctional electrocatalysts with excellent performance are highly desirable for new energy technologies. An electrocatalyst is synthesized using a straightforward two-step approach, whereby ultralow doping (0.06 wt%, Fe) and a heteroatom (N) generate defects. A defect-induced active sites accompanied by porous channels enables high catalytic activity and durability for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Experiments show that such defects enhance reaction kinetics and promote electrochemical activity with an OER overpotential of 248 mV at 10 mA cm-2 and a Tafel value of 85 mV dec-1. Through density functional theory, carbon matrix defects are observed to be beneficial for OER intermediates adsorption-desorption process. Thus, an avenue for engineering defects has opened for highly efficient multifunctional electrocatalysts by incorporating non-noble metal atoms into a carbon matrix at ultralow loading levels.& COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Shejale, Kiran P.; Krishnan, Yogeshwaran; Dharman, Ranjith Kumar; Jeong, Yeon Uk; Kim, Sung Yeol | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Tech Univ Denmark, Dept Energy Convers & Storage, Atom Scale Mat Modelling, DK-2800 Lyngby, Denmark; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | ; Shejale, Kiran/G-3183-2019; kim, sung/D-1412-2013; Krishnan, Yogeshwaran/AAQ-2140-2021 | 57063450100; 57194274577; 57287207100; 35324325200; 19337822900 | sykimknu@knu.ac.kr; | MATERIALS & DESIGN | MATER DESIGN | 0264-1275 | 1873-4197 | 227 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2023 | 7.6 | 18.1 | 1.27 | 2025-06-25 | 10 | 12 | Oxygen evolution reaction; Hydrogen evolution reaction; Porous carbon; Ultralow doping; Electrocatalysis | OXYGEN REDUCTION REACTION; TOTAL-ENERGY CALCULATIONS; ACTIVE-SITES; EVOLUTION; CATALYSIS; TRANSPORT; GRAPHENE; SPHERES; ARRAYS | Electrocatalysis; Hydrogen evolution reaction; Oxygen evolution reaction; Porous carbon; Ultralow doping | Carbon; Catalyst activity; Defect engineering; Density functional theory; Electrocatalysis; Hydrogen; Oxygen; Porous materials; Precious metals; Reaction kinetics; Carbon matrix; Defect engineering; Heteroatoms; Hydrogen evolution reactions; New energy technologies; Performance; Porous carbons; Synthesised; Two-step approach; Ultralow doping; Electrocatalysts | English | 2023 | 2023-03 | 10.1016/j.matdes.2023.111782 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cardiovascular risk of Janus kinase inhibitors compared with biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis without underlying cardiovascular diseases: a nationwide cohort study | Objectives: Despite the ethnic differences in cardiovascular (CV) risks and recent increase in the prescription of Janus kinase (JAK) inhibitors, limited evidence is available for their CV outcomes in Asian patients with rheumatoid arthritis (RA). We aimed to compare the major adverse CV events (MACEs) of JAK inhibitors to those of biologic disease-modifying antirheumatic drugs (bDMARDs) in Korean patients with RA without baseline CV disease (CVD).Methods: In a nationwide retrospective cohort study, patients newly diagnosed with RA without a history of CVD between 2013 and 2018 were identified using the National Health Insurance Service database. The cohort was followed up until the end of 2019 for the development of MACEs. Hazard ratios (HRs) for MACEs such as myocardial infarction, stroke, coronary revascularization, or all-cause death, were estimated using Cox proportional hazard regression in a propensity score-matched cohort.Results: In total, 4,230 matched patients with RA were included (846 JAK inhibitor users and 3,384 bDMARD users). The crude incidence rate (95% confidence intervals, CI) per 100 patient-years for MACEs was 0.83 (0.31-1.81) and 0.74 (0.53-1.02) in the JAK inhibitor and bDMARD groups, respectively. The risk of MACEs was not significantly different between JAK inhibitor and bDMARD users with an adjusted HR (95% CI) of 1.28 (0.53-3.11). There were no significant differences in the risk of MACEs between JAK inhibitors and bDMARDs in each subgroup according to the types of bDMARDs, age, sex, Charlson comorbidity index score, and comorbidities.Conclusion: Compared to bDMARDs, JAK inhibitors were not associated with the occurrence of MACEs in Korean patients with RA without a history of CVD. | Song, Yun-Kyoung; Lee, Gaeun; Hwang, Jinseub; Kim, Ji-Won; Kwon, Jin-Won | Daegu Catholic Univ, Coll Pharm, Gyongsan, Gyeongsangbuk D, South Korea; Daegu Univ, Dept Stat, Gyongsan, Gyeongsangbuk D, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Based Intelligent Novel Drug Discovery Educ Unit, BK21 Community 4, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | Kim, Eun/AAS-6706-2020 | 56136407200; 58692232500; 57189231296; 57251295000; 16202951700 | jwkwon@knu.ac.kr; | FRONTIERS IN PHARMACOLOGY | FRONT PHARMACOL | 1663-9812 | 14 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.4 | 18.2 | 1.36 | 2025-06-25 | 6 | 7 | janus kinase inhibitors; biologic DMARDs; cardiovascular risk; asian; rheumatoid arthritis | ETHNIC-DIFFERENCES; MORTALITY; TOFACITINIB; EVENTS | asian; biologic DMARDs; cardiovascular risk; janus kinase inhibitors; rheumatoid arthritis | abatacept; adalimumab; anakinra; baricitinib; certolizumab pegol; corticosteroid; disease modifying antirheumatic drug; etanercept; golimumab; hydroxychloroquine; infliximab; Janus kinase inhibitor; leflunomide; methotrexate; rituximab; salazosulfapyridine; tocilizumab; tofacitinib; tramadol; upadacitinib; adult; aged; all cause mortality; anemia; ankylosing spondylitis; Article; cardiovascular disease; cardiovascular risk; cerebrovascular accident; Charlson Comorbidity Index; cohort analysis; computer assisted tomography; dyslipidemia; female; heart infarction; heart muscle revascularization; human; hypertension; Korean (people); major clinical study; male; nuclear magnetic resonance imaging; propensity score; retrospective study; rheumatoid arthritis; ulcerative colitis | English | 2023 | 2023-10-30 | 10.3389/fphar.2023.1165711 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Liquid phase IR detector based on the photothermal effect of reduced graphene oxide-doped liquid crystals | Owing to the additional functionalities endowed by nanoparticle dopants, liquid crystals doped with nanoparticles are promising optical materials in a wide range of applications. In this study, we exploited the photothermal effect of reduced graphene oxide (rGO)-doped 5CB nematic liquid crystals (LC-rGO) to develop an infrared (IR) detector that is not only sensitive to IR but also measures the temperature and energy deposited in the detector. We demonstrate that rGO doping in LCs significantly enhances the IR absorption and transforms the light energy into thermal energy through the photothermal effect. The changes in the orientational order and birefringence of the LC-rGO induced by the photothermal effect under IR irradiation were manifested as an instantaneous color change in the white light probe beam. The change in the probe beam intensity was further translated into a temperature change and energy deposited in the detector. We also demonstrated that the external voltage applied to the detector significantly amplifies the photothermal responsivity by compensating for the anchoring energy of the LC. This study proposes a novel technology for detecting IR, temperature, and energy deposited in the detector by means of visible light, which has significant potential for developing large-area and high-resolution IR detectors by exploiting mature liquid crystal display technologies. | Adeshina, Mohammad A.; Lee, Hakseon; Mareddi, BharathKumar; Kang, Daekyung; Ogunleye, Abdulazeez M.; Kim, Hyunmin; Kim, Taewan; Choi, Muhan; Park, Hongsik; Park, Jonghoo | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Katholieke Univ Leuven, IMEC, Dept Elect Engn, B-3001 Leuven, Belgium; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; DGIST, Dept Interdisciplinary Engn, Daegu 42988, South Korea; Jeonbuk Natl Univ, Dept Elect Engn, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Smart Grid Res Ctr, Jeonju 54896, South Korea | ; Kim, Hyunmin/D-2875-2011; Mareddi, Bharathkumar/HSA-7535-2023; mareddi, bharathkumar/HSA-7535-2023 | 57216582237; 57734054800; 57190606826; 57211869035; 57933554600; 57192552925; 57199878285; 7402093793; 35366976200; 57196408322 | jonghoopark@knu.ac.kr; | NANOSCALE | NANOSCALE | 2040-3364 | 2040-3372 | 15 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2023 | 5.8 | 18.2 | 0.41 | 2025-06-25 | 4 | 4 | ACTUATION; TRANSITION | Infrared detectors; Liquid crystal displays; Nanoparticles; Nematic liquid crystals; Probes; Energy; Light energy; Liquid Phase; Liquid phasis; Liquid-crystals; Orientational birefringences; Orientational orders; Photothermal effects; Probe beam; Reduced graphene oxides; Graphene | English | 2023 | 2023-02-02 | 10.1039/d2nr06220h | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Mitochondrial redox system: A key target of antioxidant therapy to prevent acquired sensorineural hearing loss | Noise (noise-induced hearing loss), and ototoxic drugs (drug-induced ototoxicity), and aging (age-related hearing loss) are the major environmental factors that lead to acquired sensorineural hearing loss. So far, there have been numerous efforts to develop protective or therapeutic agents for acquired hearing loss by investigating the pathological mechanisms of each types of hearing loss, especially in cochlear hair cells and auditory nerves. Although there is still a lack of information on the underlying mechanisms of redox homeostasis and molecular redox networks in hair cells, an imbalance in mitochondrial reactive oxygen species (ROS) levels that enhance oxidative stress has been suggested as a key pathological factor eventually causing acquired sensorineural hearing loss. Thus, various types of antioxidants have been investigated for their abilities to support auditory cells in maintenance of the hearing function against ototoxic stimuli. In this review, we will discuss the scientific possibility of developing drugs that target particular key elements of the mitochondrial redox network in prevention or treatment of noise- and ototoxic drug-induced hearing loss. | Baek, Jeong-In; Kim, Ye-Ri; Lee, Kyu-Yup; Kim, Un-Kyung | Daegu Haany Univ, Coll Rehabil & Hlth, Dept Compan Anim Hlth, Gyongsan, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, KNU Creat Biores Grp BK21 Plus Project, Daegu, South Korea | Kim, Ji-Youn/A-5779-2017; Lee, Doh Young/GLR-9586-2022; Baek, Jeong-In/AAD-2164-2019 | 25651687700; 56048344100; 22135779500; 7102248968 | kimuk@knu.ac.kr; | FRONTIERS IN PHARMACOLOGY | FRONT PHARMACOL | 1663-9812 | 14 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.4 | 18.2 | 1.7 | 2025-06-25 | 11 | 11 | acquired hearing loss; noise; ototoxic drugs; ROS; mitochondria; drug development | CISPLATIN-INDUCED OTOTOXICITY; SODIUM THIOSULFATE; OXIDATIVE STRESS; N-ACETYLCYSTEINE; FREE-RADICALS; NOISE; GENTAMICIN; ROS; MECHANISMS; APOPTOSIS | acquired hearing loss; drug development; mitochondria; noise; ototoxic drugs; ROS | aminoglycoside; catalase; glutathione peroxidase; glutathione reductase; mitochondrial DNA; superoxide dismutase; apoptosis; cell death; citric acid cycle; DNA damage; endoplasmic reticulum stress; enzyme activity; hair cell (inner ear); hearing impairment; human; membrane permeability; mitochondrial membrane potential; mitochondrial redox; mitochondrial respiration; ototoxicity; oxidation reduction reaction; oxidative phosphorylation; oxidative stress; perception deafness; Short Survey; therapy effect | English | 2023 | 2023-03-31 | 10.3389/fphar.2023.1176881 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Optimizing tylosin dosage for co-infection of Actinobacillus pleuropneumoniae and Pasteurella multocida in pigs using pharmacokinetic/pharmacodynamic modeling | Formulating a therapeutic strategy that can effectively combat concurrent infections of Actinobacillus pleuropneumoniae (A. pleuropneumoniae) and Pasteurella multocida (P. multocida) can be challenging. This study aimed to 1) establish minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time kill curve, and post-antibiotic effect (PAE) of tylosin against A. pleuropneumoniae and P. multocida pig isolates and employ the MIC data for the development of epidemiological cutoff (ECOFF) values; 2) estimate the pharmacokinetics (PKs) of tylosin following its intramuscular (IM) administration (20 mg/kg) in healthy and infected pigs; and 3) establish a PK-pharmacodynamic (PD) integrated model and predict optimal dosing regimens and PK/PD cutoff values for tylosin in healthy and infected pigs. The MIC of tylosin against both 89 and 363 isolates of A. pleuropneumoniae and P. multocida strains spread widely, ranging from 1 to 256 mu g/mL and from 0.5 to 128 mu g/mL, respectively. According to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) ECOFFinder analysis ECOFF value (<= 64 mu g/mL), 97.75% (87 strains) of the A. pleuropnumoniae isolates were wild-type, whereas with the same ECOFF value (<= 64 mu g/mL), 99.72% (363 strains) of the P. multicoda isolates were considered wild-type to tylosin. Area under the concentration time curve (AUC), T-1/2, and C-max values were significantly greater in healthy pigs than those in infected pigs (13.33 h x mu g/mL, 1.99 h, and 5.79 mu g/mL vs. 10.46 h x mu g/mL, 1.83 h, and 3.59 mu g/mL, respectively) (p < 0.05). In healthy pigs, AUC(24 h)/MIC values for the bacteriostatic activity were 0.98 and 1.10 h; for the bactericidal activity, AUC(24 h)/MIC values were 1.97 and 1.99 h for A. pleuropneumoniae and P. multocida, respectively. In infected pigs, AUC(24 h)/MIC values for the bacteriostatic activity were 1.03 and 1.12 h; for bactericidal activity, AUC(24 h)/MIC values were 2.54 and 2.36 h for A. pleuropneumoniae and P. multocida, respectively. Monte Carlo simulation lead to a 2 mu g/mL calculated PK/PD cutoff. Managing co-infections can present challenges, as it often demands the administration of multiple antibiotics to address diverse pathogens. However, using tylosin, which effectively targets both A. pleuropneumoniae and P. multocida in pigs, may enhance the control of bacterial burden. By employing an optimized dosage of 11.94-15.37 mg/kg and 25.17-27.79 mg/kg of tylosin can result in achieving bacteriostatic and bactericidal effects in 90% of co-infected pigs. | Lee, Eon-Bee; Abbas, Muhammad Aleem; Park, Jonghyun; Tassew, Dereje D.; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; DIVA Bio Inc, Daegu, South Korea; Quest Pharmaceut Serv QPS, Newark, DE 19711 USA; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu, South Korea | ; Lee, Jung Bok/HHZ-3200-2022; Park, Seung-Chun/AAV-3388-2021; Abbas, Muhammad Aleem/GLT-8362-2022 | 57216526135; 57216531374; 57210160562; 55070706300; 7501832396 | derejedamte@yahoo.com;parksch@knu.ac.kr; | FRONTIERS IN PHARMACOLOGY | FRONT PHARMACOL | 1663-9812 | 14 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 4.4 | 18.2 | 0.91 | 2025-06-25 | 3 | 4 | dosage optimization; Actinobacillus pleuropneumoniae; Pasteurella multocida; pharmacokinetic/pharmacodynamic modeling; Monte Carlo simulation | DISEASE COMPLEX PRDC; ANTIMICROBIAL RESISTANCE; PHARMACOKINETICS; SUSCEPTIBILITY; CHLORAMPHENICOL; PATHOGENS; MACROLIDE; TISSUE; AGENTS; PHARMACODYNAMICS | Actinobacillus pleuropneumoniae; dosage optimization; Monte Carlo simulation; Pasteurella multocida; pharmacokinetic/pharmacodynamic modeling | antibiotic agent; tylosin; Actinobacillus pleuropneumoniae; animal experiment; animal model; antibiotic sensitivity; Article; bacterial count; bacterial growth; bacterial load; bacterial strain; bactericidal activity; bacteriostatic activity; broth dilution; coinfection; colony forming unit; controlled study; high performance liquid chromatography; liquid chromatography-mass spectrometry; male; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; nose smear; Pasteurella multocida; pharmacokinetics; pig; polymerase chain reaction | English | 2023 | 2023-09-22 | 10.3389/fphar.2023.1258403 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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