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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A Comprehensive Benchmarking Method for the Net Combination of Mobility Enhancement and Density-of-States Bottleneck | In this letter, we propose a comprehensive benchmarking method to simultaneously address mobility enhancement and density-of-states bottleneck in advanced field-effect-transistors (FETs) with novel high-mobility (high-mu) channel materials, where we focused on conventional covalent bonding semiconductors with pure and partially ionic character. This method relies only on the measured extrinsic transconductance of a long-channel FET in the saturation regime together with the source resistance, yielding the product of the effective mobility (mu eff) and effective gate capacitance (C-gₑff). We tested this method in InxGa1-xAs quantum-well high-electron-mobility transistors (HEMTs) with various indium mole fractions, such as 0.53, 0.7, 0.8 and 1, aswell as in Si n-FETs. We found that the InxGa1-xAs HEMTs with mu eff over 10,000 cm(2)/V center dot s at 300 K provided more than 20 times greater mu(eff)x C-gₑff than Si n-FETs. More specifically, the product initially improved as x increased, then showed a peak value of 10,300 mu F center dot V-1 center dot s(-1) at x of around 0.8, and degraded slightly beyond that composition. To verify the validness of the proposed method, we separately measured and analyzed C-gₑff and mu(eff) using the split-CV technique, showing excellent agreement with the ones from the proposed method. | Yun, Seung-Won; Park, Wan-Soo; Jung, Hyun-Jeong; Jeong, Hyeon-Seok; Jo, Hyeon-Bhin; Lee, In-Geun; Kim, Tae-Woo; Lee, Jae-Hak; Tsutsumi, Takuya; Sugiyama, Hiroki; Matsuzaki, Hideaki; Kim, Dae-Hyun | Kyungpook Natl Univ, Elect & Elect Engn Dept, Daegu 41566, South Korea; Univ Ulsan, Elect Engn Dept, Ulsan 41610, South Korea; NTT Device Technol Labs, Atsugi, Kanagawa 2430198, Japan | Sugiyama, Hiroki/P-6476-2019; Jo, Hyeon Bhin/HLW-9536-2023; Kim, Junghwan/AAQ-9204-2021; Kim, Yong/H-6157-2013 | 57221602680; 57222957219; 57222962491; 57200366272; 57202871742; 37016357200; 57203495132; 55690077600; 37007126500; 35417698400; 7202461821; 57212363794 | dae-hyun.kim@ee.knu.ac.kr; | IEEE ELECTRON DEVICE LETTERS | IEEE ELECTR DEVICE L | 0741-3106 | 1558-0563 | 42 | 6 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 4.816 | 24.8 | 0 | 2025-07-30 | 0 | 0 | Effectivemobility (mu(eff)); high-mobility; gate capacitance (C-g_eff); density-of-states (DOS); HEMTs | density-of-states (DOS); Effective mobility (μeff); gate capacitance (Cg_eff); HEMTs; high-mobility | Benchmarking; Gallium alloys; III-V semiconductors; Indium alloys; Semiconductor alloys; Semiconductor quantum wells; Silicon; Transistors; Benchmarking methods; Effective mobilities; Extrinsic transconductance; Field effect transistor (FETs); High electron mobility transistor (HEMTs); Mobility enhancement; Saturation regime; Source resistance; High electron mobility transistors | English | 2021 | 2021-06 | 10.1109/led.2021.3072942 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Interstitial M⁺ (M⁺ = Li⁺ or Sn⁴⁺) Doping at Interfacial BiVO4/WO3 to Promote Photoelectrochemical Hydrogen Production | Doping metals together with heterostructure assemblages is critical to address the challenges encountered while using bismuth vanadate (BVO) to yield improved light-harvesting, charge transfer, and solar-to-hydrogen conversion efficiency. To date, most approaches have focused on substitutional doping using hexavalent metal ions (Mo6+ and W6+) at vanadium or bismuth sites to improve the photoelectrochemical (PEC) performance. Unlike conventional substitution, which produces V-substituted sites that function as hole traps and reduce the activity, herein, we used a simple hydrothermal and metal-organic decomposition approach to introduce interstitial [Li+ or Sn4+]n-doping in BVO (n = 0.25, 0.5, 1.0, 1.5, and 2.0 mM) interfaced with tungsten oxide (WO). The resulting Sn-doped BVO/WO (0.5 mM) shows a reproducible photocurrent density of 1.65 +/- 0.07 mA cm(-2) and 4.28 +/- 0.15 mA cm(-2) at 1.23 VRHE for water oxidation and sulfite oxidation, respectively, with a superior quantum efficiency (60% at 470 nm) and long-term durability (>10000 s) under standard AM 1.5 G light irradiation (1 sun). The results show that the Sn-doped BVO/WO exhibited an enhanced PEC performance approximately three times better than that of pristine BVO/WO, thus enabling continuous H-2 production (similar to 800 mu mol.cm(-2)) and highlighting the beneficial role of strategically controlled interstitial dopant concentration. Mott-Schottky analysis revealed an increase in the donor concentration for Li-BVO/WO (similar to 2.3-fold) and Sn-BVO/WO (3.5-fold), related to the reference BVO/WO photoelectrode. This work highlights the use of low-cost dopants and heterojunction photocatalysts to carry out hydrogen evolution reactions at a significantly improved rate. | Patil, Santosh S.; Lee, Jaewon; Park, Eunoak; Nagappagari, Lakshmana Reddy; Lee, Kiyoung | Kyungpook Natl Univ, Res Inst Environm Sci & Technol, Daegu 41566, South Korea; Inha Univ, Dept Chem & Chem Engn, Incheon 22212, South Korea | Lee, Kiyoung/J-8680-2013; N, Dr. Lakshmana Reddy/K-2238-2019; Nagappagari, Lakshmana Reddy/K-2238-2019 | 57212424760; 58744440600; 57267047800; 56499352000; 57219211501 | kiyoung@inha.ac.kr; | ACS APPLIED ENERGY MATERIALS | ACS APPL ENERG MATER | 2574-0962 | 4 | 12 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 6.959 | 24.8 | 0.49 | 2025-07-30 | 8 | 9 | bismuth vanadate; interstitial metal doping; heterojunction; hydrogen energy; water splitting | CHARGE SEPARATION; FACILE SYNTHESIS; WATER; PHOTOANODES; SURFACE; EFFICIENT; PERFORMANCE; TRANSPORT; INSIGHT; METAL | bismuth vanadate; heterojunction; hydrogen energy; interstitial metal doping; water splitting | Bismuth; Charge transfer; Decomposition; Hydrogen production; Metal ions; Organometallics; Photoelectrochemical cells; Solar power generation; Tungsten compounds; Bismuth vanadates; Hydrogen Energy; Interstitial metal doping; Interstitial metals; Interstitials; Li +; Metal-doping; Photoelectrochemical performance; Tungsten oxide; Water splitting; Heterojunctions | English | 2021 | 2021-12-27 | 10.1021/acsaem.1c02294 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | CORM-2-Solid Lipid Nanoparticles Maintain Integrity of Blood-Spinal Cord Barrier After Spinal Cord Injury in Rats (vol 57, pg 2671, 2020) | Joshi, Hari Prasad; Kumar, Hemant; Choi, Un Yong; Lim, Yong Cheol; Choi, Hyemin; Kim, Juri; Kyung, Jae Won; Sohn, Seil; Kim, Kyoung-Tae; Kim, Jin-Ki; Han, Inbo | CHA Univ, Sch Med, Dept Neurosurg, CHA Bundang Med Ctr, 59 Yaptap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea; Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad, Dept Pharmacol & Toxicol, Gandhinagar, Gujarat, India; Ajou Univ Hosp, Dept Neurosurg, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Hanyang Univ, Coll Pharm, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 15588, Gyeonggi Do, South Korea | Kumar, Hemant/G-4576-2018 | 57201974279; 54949405700; 57209540640; 57212613160; 57193951350; 57205440229; 56895826800; 55047974500; 57201369790; 50061383600; 9338449900 | hanib@cha.ac.kr; | MOLECULAR NEUROBIOLOGY | MOL NEUROBIOL | 0893-7648 | 1559-1182 | 58 | 4 | SCIE | NEUROSCIENCES | 2021 | 5.686 | 24.9 | 0 | 2025-07-30 | 0 | 0 | erratum | English | 2021 | 2021-04 | 10.1007/s12035-020-02233-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Resolvin D3 Promotes Inflammatory Resolution, Neuroprotection, and Functional Recovery After Spinal Cord Injury | Resolvins, a new family from the endogenous specialized pro-resolving mediators (SPMs), promote the resolution of the inflammatory response. Resolvin D3 (RvD3), a docosahexaenoic acid (DHA) product, has been known to suppress the inflammatory response. However, the anti-inflammatory and neuroprotective effects of RvD3 are not known in a model of spinal cord injury (SCI). Here, we investigated the anti-inflammatory and neuroprotective effect of RvD3 in a mouse model of SCI. Processes associated with anti-inflammation and angiogenesis were studied in RAW 264.7 cells and the human brain endothelial cell line hCMEC/D3, respectively. Additionally, female C57BL/6 mice were subjected to moderate compression SCI (20-g weight compression for 1 min) followed by intrathecal injection of vehicle or RvD3 (1 mu g/20 mu L) at 1 h post-SCI. RvD3 decreased the lipopolysaccharide (LPS)-induced production of inflammatory mediators and nitric oxide (NO) in RAW 264.7 cells and promoted an angiogenic effect in the hCMEC/D3 cell line. Treatment with RvD3 improved locomotor recovery and reduced thermal hyperalgesia in SCI mice compared with vehicle treatment at 14 days post-SCI. Remarkably, RvD3-treated mice exhibited reduced expression of inflammatory cytokines (TNF-alpha, IL6, IL1 beta) and chemokines (CCL2, CCL3). Also, RvD3-treated mice exhibited increased expression of tight junction proteins such as zonula occludens (ZO)-1 and occludin. Furthermore, immunohistochemistry showed a decreased level of gliosis (GFAP, Iba-1) and neuroinflammation (CD68, TGF-beta) and enhanced neuroprotection. These data provide evidence that intrathecal injection of RvD3 represents a promising therapeutic strategy to promote inflammatory resolution, neuroprotection, and neurological functional recovery following SCI. | Kim, Juri; Joshi, Hari Prasad; Sheen, Seung Hun; Kim, Kyoung-Tae; Kyung, Jae Won; Choi, Hyemin; Kim, Ye Won; Kwon, Su Yeon; Roh, Eun Ji; Choi, Un Yong; Sohn, Seil; Kim, Yong Ho; Park, Chul-Kyu; Kumar, Hemant; Han, In-Bo | CHA Univ, Dept Neurosurg, CHA Bundang Med Ctr, Sch Med, Seongnam Si 13496, Gyeonggi Do, South Korea; CHA Univ, Sch Med, Dept Biomed Sci, Seongnam Si, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Gachon Univ, Coll Med, Gachon Pain Ctr, Incheon, South Korea; Gachon Univ, Coll Med, Dept Physiol, Incheon, South Korea; Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad, Dept Pharmacol & Toxicol, Gandhinagar, Gujarat, India | Kumar, Hemant/G-4576-2018 | 57205440229; 57201974279; 57523864600; 57201369790; 56895826800; 57193951350; 57218609855; 57219127846; 57219129044; 57209540640; 55047974500; 35314300700; 55821963900; 54949405700; 9338449900 | hanib@cha.ac.kr; | MOLECULAR NEUROBIOLOGY | MOL NEUROBIOL | 0893-7648 | 1559-1182 | 58 | 1 | SCIE | NEUROSCIENCES | 2021 | 5.686 | 24.9 | 1.04 | 2025-07-30 | 15 | 14 | Spinal cord injury; Secondary injury; Inflammatory response; Resolvins; Resolvin D3; Pain | LIPID MEDIATORS; GROWTH-FACTOR; THERAPY; BARRIER; BRAIN; PAIN; D2; METHYLPREDNISOLONE; REVASCULARIZATION; EXPRESSION | Inflammatory response; Pain; Resolvin D3; Resolvins; Secondary injury; Spinal cord injury | Animals; Anti-Inflammatory Agents; Cell Movement; Cicatrix; Endothelial Cells; Fatty Acids, Unsaturated; Female; Fibrosis; Inflammation; Locomotion; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Neuroglia; Neuroprotection; Neuroprotective Agents; Nitric Oxide; Pain; Phenotype; RAW 264.7 Cells; Recovery of Function; Spinal Cord Injuries; Tight Junction Proteins; antiinflammatory agent; interleukin 1beta; interleukin 6; macrophage inflammatory protein 1alpha; monocyte chemotactic protein 1; neuroprotective agent; occludin; protein ZO1; resolvin D3; tight junction protein; transforming growth factor beta; tumor necrosis factor; unclassified drug; antiinflammatory agent; neuroprotective agent; nitric oxide; resolvin D3; tight junction protein; unsaturated fatty acid; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; controlled study; convalescence; drug determination; drug effect; female; functional assessment; gene sequence; human; human cell; mouse; neuroprotection; nonhuman; protein expression; RAW 264.7 cell line; spinal cord injury; angiogenesis; animal; biosynthesis; C57BL mouse; cell motion; complication; convalescence; endothelium cell; fibrosis; glia; inflammation; locomotion; metabolism; pain; pathology; pathophysiology; phenotype; scar; spinal cord injury | English | 2021 | 2021-01 | 10.1007/s12035-020-02118-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A 3D-CNN model with CT-based parametric response mapping for classifying COPD subjects | Chronic obstructive pulmonary disease (COPD) is a respiratory disorder involving abnormalities of lung parenchymal morphology with different severities. COPD is assessed by pulmonary-function tests and computed tomography-based approaches. We introduce a new classification method for COPD grouping based on deep learning and a parametric-response mapping (PRM) method. We extracted parenchymal functional variables of functional small airway disease percentage (fSAD%) and emphysema percentage (Emph%) with an image registration technique, being provided as input parameters of 3D convolutional neural network (CNN). The integrated 3D-CNN and PRM (3D-cPRM) achieved a classification accuracy of 89.3% and a sensitivity of 88.3% in five-fold cross-validation. The prediction accuracy of the proposed 3D-cPRM exceeded those of the 2D model and traditional 3D CNNs with the same neural network, and was comparable to that of 2D pretrained PRM models. We then applied a gradient-weighted class activation mapping (Grad-CAM) that highlights the key features in the CNN learning process. Most of the class-discriminative regions appeared in the upper and middle lobes of the lung, consistent with the regions of elevated fSAD% and Emph% in COPD subjects. The 3D-cPRM successfully represented the parenchymal abnormalities in COPD and matched the CT-based diagnosis of COPD. | Ho, Thao Thi; Kim, Taewoo; Kim, Woo Jin; Lee, Chang Hyun; Chae, Kum Ju; Bak, So Hyeon; Kwon, Sung Ok; Jin, Gong Yong; Park, Eun-Kee; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Internal Med, Chunchon, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Environm Hlth Ctr, Chunchon, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Radiol, Seoul, South Korea; Univ Iowa, Coll Med, Dept Radiol, Iowa City, IA 52242 USA; Jeonbuk Natl Univ, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Dept Radiol,Res Inst Clin Med, Jeonju, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Dept Radiol, Sch Med, Chunchon, South Korea; Kosin Univ, Coll Med, Dept Med Humanities & Social Med, Busan, South Korea | Kim, Woo/A-8216-2019; Choi, Sanghun/AGS-7430-2022; Lee, Chang-Hoon/AAC-7650-2021 | 57221374670; 57192910015; 56560422500; 57196253438; 57195310676; 57192422019; 55548156100; 55663719500; 57216814178; 55847101000 | s-choi@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 3.24 | 2025-07-30 | 51 | 72 | OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION; REGISTRATION; QUANTIFICATION; AIRWAYS; IMAGES | Aged; Case-Control Studies; Deep Learning; Female; Humans; Imaging, Three-Dimensional; Lung; Male; Middle Aged; Neural Networks, Computer; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Tomography, X-Ray Computed; aged; case control study; chronic obstructive lung disease; classification; diagnostic imaging; female; human; lung; lung function test; male; middle aged; procedures; three-dimensional imaging; x-ray computed tomography | English | 2021 | 2021-01-08 | 10.1038/s41598-020-79336-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A nationwide cohort study on growth impairment by cleft lip with or without palate | There are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children's Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66-71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries. | Ryu, Jeong Yeop; Park, Tae Hyun; Lee, Joon Seok; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae; Choi, Kang Young | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, 680 Gukchaebosanro, Daegu 41405, South Korea | Ryu, Jeong Yeop/GLQ-9419-2022; LEE, JIN/Q-3108-2018; Yang, Jung/R-7806-2019 | 56366349400; 57223690181; 56496041000; 55171704700; 7404007181; 55662871100; 57203745682 | kychoi@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.38 | 2025-07-30 | 8 | 9 | WEIGHT; CHILDREN; LENGTH; BIRTH | Anthropometry; Case-Control Studies; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cohort Studies; Female; Growth; Humans; Male; Republic of Korea; anthropometry; case control study; child; cleft lip; cleft palate; cohort analysis; female; growth; human; male; pathology; preschool child; South Korea | English | 2021 | 2021-12-08 | 10.1038/s41598-021-03052-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A novel immune prognostic index for stratification of high-risk patients with early breast cancer | The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated into most multigene assays. Here, using public gene expression microarray datasets, we classified breast cancer patients into three risk groups according to clinical risk and proliferation risk. We then developed the immune prognostic index based on expression of five immune response-related genes (TRAT1, IL2RB, CTLA4, IGHM and IL21R) and lymph node status to predict the risk of recurrence in the clinical and proliferation high-risk (CPH) group. The 10-year probability of disease-free survival (DFS) or distant metastasis-free survival (DMFS) of patients classified as high risk according to the immune prognostic index was significantly lower than those of patients classified as intermediate or low risk. Multivariate analysis revealed that the index is an independent prognostic factor for DFS or DMFS. Moreover, the C-index revealed that it is superior to clinicopathological variables for predicting prognosis. Its prognostic significance was also validated in independent datasets. The immune prognostic index identified low-risk patients among patients classified as CPH, regardless of the molecular subtype of breast cancer, and may overcome the limitations of current multigene assays. | Lee, Hannah; Kwon, Mi Jeong; Koo, Beom-Mo; Park, Hee Geon; Han, Jinil; Shin, Young Kee | Seoul Natl Univ, Coll Nat Sci, Interdisciplinary Program Bioinformat, Seoul 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul 08826, South Korea; Gencurix Inc, Seoul 08394, South Korea; Seoul Natl Univ, Coll Pharm, Dept Pharm, Lab Mol Pathol & Canc Genom, 1 Gwanak Ro, Seoul 08826, South Korea | Shin, Young/C-8929-2011 | 55634905800; 35278164800; 57221371907; 57221379713; 56982070700; 26428533000 | ykeeshin@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.27 | 2025-07-30 | 7 | 7 | GENE-EXPRESSION; PREDICTOR; SIGNATURE; THERAPY; RECURRENCE; BIOMARKERS; DECISIONS; WOMEN | Adaptor Proteins, Signal Transducing; Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; CTLA-4 Antigen; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Heavy Chain Disease; Humans; Immunoglobulin mu-Chains; Interleukin-2 Receptor beta Subunit; Interleukin-21 Receptor alpha Subunit; Membrane Proteins; Middle Aged; Prognosis; CTLA4 protein, human; cytotoxic T lymphocyte antigen 4; IGHM protein, human; IL21R protein, human; IL2RB protein, human; immunoglobulin mu chain; interleukin 2 receptor beta; interleukin 21 receptor alpha; membrane protein; signal transducing adaptor protein; TRAT1 protein, human; tumor marker; adult; aged; breast tumor; disease free survival; female; gene expression regulation; genetics; heavy chain disease; human; immunology; middle aged; mortality; prognosis | English | 2021 | 2021-01-08 | 10.1038/s41598-020-80274-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A preliminary study of post-progressive nail-art effects on in vivo nail plate using optical coherence tomography-based intensity profiling assessment | Nail beautification is a widely applied gender independent practice. Excessive nail beautifications and nail-arts have a direct impact on the nail structure and can cause nail disorders. Therefore, the assessment of post-progressive nail-art effects on the nail is essential to maintain optimal nail health and to avoid any undesirable disorders. In this study, in vivo nails were examined in control stage, with a nail-art stage, and after removing the nail-art stage using a 1310 nm spectral-domain optical coherence tomography (SD-OCT) system. The acquired cross-sectional OCT images were analyzed by a laboratory customized signal processing algorithm to obtain scattered intensity profiling assessments that could reveal the effects of nail beautification on the nail plate. The formation and progression of cracks on the nail plate surface were detected as an effect of nail beautification after 72 h of nail-art removal. Changes in backscattered light intensity and nail plate thickness of control and art-removed nails were quantitatively compared. The results revealed the potential feasibility of the developed OCT-based inspection procedure to diagnose post-progressive nail-art effects on in vivo nail plate, which can be helpful to prevent nail plate damages during art removal through real-time monitoring of the boundary between the nail plate and nail-art. Besides nail-art effects, the developed method can also be used for the investigation of nail plate abnormalities by examining the inconsistency of internal and external nail plate structure, which can be diagnosed with both qualitative and quantitative assessments from a clinical perspective. | Abu Saleah, Sm; Kim, Pilun; Seong, Daewoon; Wijesinghe, Ruchire Eranga; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; LG Elect, Prod Engn Res Inst, 222 LG Ro Jinwi Myeon, Pyeongtaek Si 17790, Gyeonggi Do, South Korea; Univ Sri Jayewardenepura, Fac Technol, Dept Mat & Mech Technol, Pitipana 10200, Homagama, Sri Lanka | Wijesinghe, Ruchire/K-3797-2016 | 57218499446; 56967482800; 57212512353; 56018152300; 24171094000; 7601373350 | msjeon@knu.ac.kr;jeehk@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.49 | 2025-07-30 | 5 | 9 | HIGH-FREQUENCY ULTRASOUND; IMAGING MODALITY; DRUG-DELIVERY; PSORIASIS; MICROSCOPY; DERMOSCOPY; THICKNESS; DIAGNOSIS; DISEASE; TUMORS | Adult; Cross-Sectional Studies; Female; Humans; Nail Diseases; Nails; Tomography, Optical Coherence; adult; cross-sectional study; diagnostic imaging; female; human; nail; nail disease; optical coherence tomography; pathophysiology; procedures | English | 2021 | 2021-01-12 | 10.1038/s41598-020-79497-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A robust approach for industrial small-object detection using an improved faster regional convolutional neural network | With the increasing pace in the industrial sector, the need for a smart environment is also increasing and the production of industrial products in terms of quality always matters. There is a strong burden on the industrial environment to continue to reduce impulsive downtime, concert deprivation, and safety risks, which needs an efficient solution to detect and improve potential obligations as soon as possible. The systems working in industrial environments for generating industrial products are very fast and generate products rapidly, sometimes leading to faulty products. Therefore, this problem needs to be solved efficiently. Considering this problem in terms of faulty small-object detection, this study proposed an improved faster regional convolutional neural network-based model to detect the faults in the product images. We introduced a novel data-augmentation method along with a bi-cubic interpolation-based feature amplification method. A center loss is also introduced in the loss function to decrease the inter-class similarity issue. The experimental results show that the proposed improved model achieved better classification accuracy for detecting our small faulty objects. The proposed model performs better than the state-of-the-art methods. | Saeed, Faisal; Ahmed, Muhammad Jamal; Gul, Malik Junaid; Hong, Kim Jeong; Paul, Anand; Kavitha, Muthu Subash | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Nagasaki Univ, Sch Informat & Data Sci, Nagasaki, Japan | Ahmed, Muhammad Jamal/LRC-8144-2024; Kavitha, M.S./AAI-6438-2020; Gul, Malik junaid jami/O-1392-2018; Gul, Malik/O-1392-2018; Paul, Anand/V-6724-2017; Saeed, Faisal/HNT-0710-2023 | 54892561900; 57222549949; 57203752948; 55138548100; 56650522400; 57218147465 | paul.editor@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 1.14 | 2025-07-30 | 25 | 25 | article; convolutional neural network; loss of function mutation | English | 2021 | 2021-12-03 | 10.1038/s41598-021-02805-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Arsenic hexoxide has differential effects on cell proliferation and genome-wide gene expression in human primary mammary epithelial and MCF7 cells | Arsenic is reportedly a biphasic inorganic compound for its toxicity and anticancer effects in humans. Recent studies have shown that certain arsenic compounds including arsenic hexoxide (AS(4)O(6); hereafter, AS6) induce programmed cell death and cell cycle arrest in human cancer cells and murine cancer models. However, the mechanisms by which AS6 suppresses cancer cells are incompletely understood. In this study, we report the mechanisms of AS6 through transcriptome analyses. In particular, the cytotoxicity and global gene expression regulation by AS6 were compared in human normal and cancer breast epithelial cells. Using RNA-sequencing and bioinformatics analyses, differentially expressed genes in significantly affected biological pathways in these cell types were validated by real-time quantitative polymerase chain reaction and immunoblotting assays. Our data show markedly differential effects of AS6 on cytotoxicity and gene expression in human mammary epithelial normal cells (HUMEC) and Michigan Cancer Foundation 7 (MCF7), a human mammary epithelial cancer cell line. AS6 selectively arrests cell growth and induces cell death in MCF7 cells without affecting the growth of HUMEC in a dose-dependent manner. AS6 alters the transcription of a large number of genes in MCF7 cells, but much fewer genes in HUMEC. Importantly, we found that the cell proliferation, cell cycle, and DNA repair pathways are significantly suppressed whereas cellular stress response and apoptotic pathways increase in AS6-treated MCF7 cells. Together, we provide the first evidence of differential effects of AS6 on normal and cancerous breast epithelial cells, suggesting that AS6 at moderate concentrations induces cell cycle arrest and apoptosis through modulating genome-wide gene expression, leading to compromised DNA repair and increased genome instability selectively in human breast cancer cells. | Kim, Donguk; Park, Na Yeon; Kang, Keunsoo; Calderwood, Stuart K.; Cho, Dong-Hyung; Bae, Ill Ju; Bunch, Heeyoun | Kyungpook Natl Univ, Sch Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Four KNU Creat Biores Grp, Daegu 41566, South Korea; Dankook Univ, Dept Microbiol, Coll Nat Sci, Cheonan 31116, South Korea; Harvard Med Sch, Dept Radiat Oncol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA; Chemas Pharmaceut, Dept Drug Dev, Seoul 06163, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea | Bunch, Heeyoun/JAX-3215-2023; Choi, Hye Rin/JDV-9065-2023; Kang, Keunsoo/AFM-7746-2022 | 58732007900; 57190609826; 19934117300; 7103094191; 35093684400; 7004882619; 56336812200 | cjsbij@gmail.com;heeyounbunch@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.54 | 2025-07-30 | 8 | 11 | ACUTE PROMYELOCYTIC LEUKEMIA; KAPPA-B ACTIVITY; TETRAARSENIC OXIDE; DNA-DAMAGE; RETINOIC ACID; INDUCED APOPTOSIS; CANCER-TREATMENT; ATM MUTATIONS; TRIOXIDE; BREAST | Apoptosis; Arsenic; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Cycle; Cell Cycle Checkpoints; Cell Differentiation; Cell Proliferation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; MCF-7 Cells; Primary Cell Culture; Tumor Cells, Cultured; arsenic; arsenic trioxide; organoarsenic derivative; apoptosis; breast tumor; cell cycle; cell cycle checkpoint; cell differentiation; cell proliferation; drug effect; female; gene expression; gene expression regulation; genetics; human; mammary gland; MCF-7 cell line; metabolism; primary cell culture; tumor cell culture | English | 2021 | 2021-02-12 | 10.1038/s41598-021-82551-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Erratum | Author Correction: Automated rotator cuff tear classification using 3D convolutional neural network (Scientific Reports, (2020), 10, 1, (15632), 10.1038/s41598-020-72357-0) | The original version of this Article contained errors in the Abstract. “The VRN-based 3D CNN outperformed orthopedists specialized in shoulder and general orthopedists in binary accuracy (92.5% vs. 76.4% and 68.2%), top-1 accuracy (69.0% vs. 45.8% and 30.5%), top-1±1 accuracy (87.5% vs. 79.8% and 71.0%), sensitivity (0.94 vs. 0.86 and 0.90), and specificity (0.90 vs. 0.58 and 0.29).” now reads: “The VRN-based 3D CNN outperformed orthopedists specialized in shoulder and general orthopedists in binary accuracy (92.5% vs. 76.4% and 68.2%), top-1 accuracy (69.0% vs. 45.8% and 30.5%), top-1±1 accuracy (87.5% vs. 79.8% and 71.0%), sensitivity (0.92 vs. 0.89 and 0.93), and specificity (0.86 vs. 0.61 and 0.26).” The original Article has been corrected. © The Author(s) 2021 | Shim, Eungjune; Kim, Joon Yub; Yoon, Jong Pil; Ki, Se‑Young; Lho, Taewoo; Kim, Youngjun; Chung, Seok Won | Center for Bionics, Korea Institute of Science and Technology, Seoul, 02792, South Korea; Department of Orthopedic Surgery, Yeson Hospital, Bucheon, 14555, South Korea; Department of Orthopaedic Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Orthopaedic Surgery, Center for Shoulder and Elbow Surgery, Konkuk University School of Medicine, Seoul, 143‑729, South Korea; Department of Orthopaedic Surgery, Center for Shoulder and Elbow Surgery, Konkuk University School of Medicine, Seoul, 143‑729, South Korea; Center for Bionics, Korea Institute of Science and Technology, Seoul, 02792, South Korea; Department of Orthopaedic Surgery, Center for Shoulder and Elbow Surgery, Konkuk University School of Medicine, Seoul, 143‑729, South Korea | 57195289654; 57219148839; 36098548400; 57191984084; 57219146100; 57211346021; 37065938600 | junekim@kist.re.kr;smilecsw@gmail.com; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 3.01 | 2025-07-30 | 3 | erratum | English | Final | 2021 | 10.1038/s41598-021-95469-7 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Erratum | Author Correction: Boundary integral equation method for resonances in gradient index cavities designed by conformal transformation optics (Scientific Reports, (2019), 9, 1, (19684), 10.1038/s41598-019-55572-2) | The Author Contributions section in this Article is incorrect. “The late S.-Y.L. conceived the original idea. J.-W.R., S.-Y.L., M.C. and I.K. formulated the method. J.-W.R., J.C., Y.K. and S.-J.P. performed numerical calculation. J.-W.R., J.C., S.R., M.C. and I.K. wrote the manuscript. All authors analyzed the data, discussed the results and provided feedback for the manuscript.” should read: “The late S.-Y.L. conceived the original idea for this BEM. J.-W.R., S.-Y.L., M.C. and I.K. formulated the method. J.-W.R., J.C., Y.K. and S.-J.P. performed numerical calculation. J.-W.R., J.C., S.R., M.C. and I.K. wrote the manuscript. All authors analyzed the data, discussed the results and provided feedback for the manuscript.” Also, this Article contains an error in the Conclusion section. “In order to obtain the resonant mode functions in TCs designed by conformal TO, we have developed a pure BEM based on the fact that the Green’s functions of interior and exterior regions are known in the RV and the physical spaces, respectively, which are connected by a conformal mapping. For the verification of our BEM, we have respectively, which are connected by a conformal mapping. For the verification of our BEM, we have calculated resonant modes in limaçon-shaped TCs and compared those with the corresponding results from FEM.” should read: “In order to obtain the resonant mode functions in TCs designed by conformal TO, we have developed a pure BEM based on the fact that the Green’s functions of interior and exterior regions are known in the RV space and the physical space, respectively, which are connected by a conformal mapping. For the verification of our BEM, we have calculated resonant modes in limaçon-shaped TCs and compared those with the corresponding results from FEM.” © 2021, The Author(s). | Ryu, Jung-Wan; Cho, Jinhang; Lee, Soo-Young; Kim, Yushin; Park, Sang-Jun; Rim, Sunghwan; Choi, Muhan; Kim, Inbo | Center for Theoretical Physics of Complex Systems, Institute for Basic Science (IBS), Daejeon, 34126, South Korea; Digital Technology Research Center, Kyungpook National University, Daegu, 41566, South Korea; School of Electronics Engineering, Kyungpook National University, Daegu, 41566, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, South Korea; School of Electronics Engineering, Kyungpook National University, Daegu, 41566, South Korea; Digital Technology Research Center, Kyungpook National University, Daegu, 41566, South Korea; Digital Technology Research Center, Kyungpook National University, Daegu, 41566, South Korea, School of Electronics Engineering, Kyungpook National University, Daegu, 41566, South Korea; Digital Technology Research Center, Kyungpook National University, Daegu, 41566, South Korea | 12768616200; 18933904800; 57202327368; 57196173536; 58969718200; 7005692465; 7402093793; 56278391800 | mhchoi@ee.knu.ac.kr;ibkim@ee.knu.ac.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0 | 2025-07-30 | 0 | erratum | English | Final | 2021 | 10.1038/s41598-021-81203-w | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Erratum | Author Correction: Clinical application of the experimental ADL test for patients with cognitive impairment: pilot study (Scientific Reports, (2021), 11, 1, (356), 10.1038/s41598-020-78289-z) | This Article contains errors in Reference 16 which is incorrectly given as: Al-Jumaily, A. et al. Ambient assisted living technologies for older adults with cognitive and physical impairments: a review. Eur. Rev. Med. Pharmaco. 23, 10470–10481 (2019). The correct Reference 16 appears below as Reference [1]. © 2021, The Author(s). | Lim, Yong-Hyun; Baek, Yookyeong; Kang, Soon Ju; Kang, Kyunghun; Lee, Ho-Won | Center of Self-Organizing Software-Platform, Kyungpook National University, Daegu, South Korea, Department of Neurology, School of Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea; Department of Neurology, School of Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea; School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South Korea; Department of Neurology, School of Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea; Department of Neurology, School of Medicine, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea, Brain Science and Engineering Institute, Kyungpook National University, Daegu, South Korea | 57202416711; 57221468229; 55666313900; 55365592200; 35337240700 | neuromd@knu.ac.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0 | 2025-07-30 | 0 | erratum | English | Final | 2021 | 10.1038/s41598-021-88216-5 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Erratum | Author Correction: Genome insight and description of antibiotic producing Massilia antibiotica sp. nov., isolated from oil-contaminated soil (Scientific Reports, (2021), 11, 1, (6695), 10.1038/s41598-021-86232-z) | The original version of this Article contained an error in the Result and discussions section, under the subheading ‘Description of Massilia antibiotica sp. nov.’, where, “The type strain, TW-1T 1T (= KACC 21627T = NBRC 114363T), was isolated from oil-contaminated experimental soil in Kyonggi University, Republic of Korea.” now reads: “The type strain, TW-1T (= KACC 21627T = NBRC 114363T), was isolated from oil-contaminated experimental soil in Kyonggi University, Republic of Korea.” The original Article has been corrected. © 2021 The Author(s). | Dahal, Ram Hari; Chaudhary, Dhiraj Kumar; Kim, Jaisoo | Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, 16227, Kyonggi‑Do, South Korea, Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, 16227, Kyonggi‑Do, South Korea, Department of Environmental Engineering, Korea University Sejong Campus, Sejong City, 30019, South Korea; Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, 16227, Kyonggi‑Do, South Korea | 57110097800; 57191257432; 8718834500 | jkimtamu@kgu.ac.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 1.51 | 2025-07-30 | 1 | erratum | English | Final | 2021 | 10.1038/s41598-021-92164-5 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis | Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive function was evaluated between April 2010 and August 2015 using the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment in 1,240 Korean PICASSO participants. Patients for whom baseline and follow-up cognitive test results and at least five valid BP readings were available were included. A restricted maximum likelihood-based Mixed Model for Repeated Measures was used to compare changes in cognitive function over time. Among a total of 746 participants (64.6 +/- 10.8 years; 35.9% female). Baseline mean-MMSE score was 24.9 +/- 4.7. The median number of BP readings was 11. During a mean follow-up of 2.6 years, mean baseline and last follow-up MMSE scores were 25.4 +/- 4.8 vs. 27.8 +/- 4.4 (the lowest BPV group) and 23.9 +/- 5.2 vs. 23.2 +/- 5.9 (the highest BPV group). After adjusting for multiple variables, higher BPV was independently associated with faster cognitive decline over time. However, no significant intergroup difference in cognitive changes associated with mean systolic BP was observed. Further research is needed to elucidate how BPV might affect cognitive function. | Kim, Yerim; Lim, Jae-Sung; Oh, Mi Sun; Yu, Kyung-Ho; Lee, Ji Sung; Park, Jong-Ho; Kim, Yong-Jae; Rha, Joung-Ho; Hwang, Yang-Ha; Heo, Sung Hyuk; Ahn, Seong Hwan; Lee, Ju-Hun; Kwon, Sun U. | Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurol, Seoul, South Korea; Hallym Univ, Sacred Heart Hosp, Coll Med, Dept Neurol, Anyang, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Clin Res Ctr,Asan Inst Life Sci, Seoul, South Korea; Hanyang Univ, Coll Med, Myongji Hosp, Dept Neurol, Goyang, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Inha Univ Hosp, Dept Neurol, Incheon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyung Hee Univ, Med Ctr, Dept Neurol, Seoul, South Korea; Chosun Univ Hosp, Dept Neurol, Gwangju, South Korea | Kim, Yong-Jae/JQW-5758-2023; Heo, Sung/P-3529-2019; Lim, Jae-Sung/D-5555-2012; HWANG, Yang-Ha/F-3068-2013 | 56553796100; 55729369300; 24492191600; 8858398400; 57212925539; 55716977200; 55865497600; 6701393879; 7402311308; 18835720200; 57200401172; 36243671200; 7402624264 | leejuhun@kdh.or.kr;sukwon@amc.seoul.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.92 | 2025-07-30 | 20 | 20 | VISIT-TO-VISIT; CEREBRAL-HEMORRHAGE PICASSO; HIGH-RISK; INDEPENDENT DETERMINANTS; CARDIOVASCULAR EVENTS; BRAIN ATROPHY; AMYLOID-BETA; HEART-RATE; DEMENTIA; PREVENTION | Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Cognition; Cognitive Dysfunction; Comorbidity; Female; Follow-Up Studies; Humans; Hypertension; Ischemic Stroke; Likelihood Functions; Longitudinal Studies; Male; Mental Status and Dementia Tests; Middle Aged; Republic of Korea; Risk Factors; aged; blood pressure; brain ischemia; clinical trial; cognition; cognitive defect; comorbidity; controlled study; dementia assessment; female; follow up; human; hypertension; longitudinal study; male; middle aged; multicenter study; randomized controlled trial; risk factor; South Korea; statistical model; very elderly | English | 2021 | 2021-03-03 | 10.1038/s41598-021-83945-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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