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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | The Effect of Perioral Scan and Artificial Skin Markers on the Accuracy of Virtual Dentofacial Integration: Stereophotogrammetry Versus Smartphone Three-Dimensional Face-Scanning | This study evaluated the effects of different matching methods on the accuracy of dentofacial integration in stereophotogrammetry and smartphone face-scanning systems. The integration was done (N = 30) with different matching areas (n = 10), including teeth image only (TO), perioral area without markers (PN) and with markers (PM). The positional accuracy of the integrated models was assessed by measuring the midline linear deviations and incisal line canting between the experimental groups and laser scanner-based reference standards. Kruskal-Wallis and Mann-Whitney U tests were used for statistical analyses (alpha = 0.05). The PM method exhibited the smallest linear deviations in both systems; while the highest deviations were found in the TO in stereophotogrammetry; and in PN in smartphone. For the incisal line canting; the canting degree was the lowest in the PM method; followed by that in the TO and the PN in both systems. Although stereophotogrammetry generally exhibited higher accuracy than the smartphone; the two systems demonstrated no significant difference when the perioral areas were used for matching. The use of perioral scans with markers enables accurate dentofacial image integration; however; cautions should be given on the accuracy of the perioral image obtained without the use of markers. | Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | Mai, Hang-Nga/Q-9865-2018 | 56964780900; 35770948000 | maihangnga1403@knu.ac.kr;deweylee@knu.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 1 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.63 | 2025-07-30 | 15 | 17 | intraoral scanners; face scanners; perioral scans; skin markers; accuracy; dentofacial integration; stereophotogrammetry; smartphone; three-dimensional face-scanning | DENTAL CASTS; SMILE; VENEERS; DESIGN; IMAGES | Accuracy; Dentofacial in-tegration; Face scanners; Intraoral scanners; Perioral scans; Skin markers; Smartphone; Stereophotogrammetry; Three-dimensional face-scanning | Biomarkers; Computer-Aided Design; Face; Humans; Imaging, Three-Dimensional; Mouth; Photogrammetry; Skin; Smartphone; biological marker; accuracy assessment; dental health; mobile phone; photogrammetry; scanner; software; accuracy; adult; Article; controlled study; digital technology; human; human experiment; image analysis; Kruskal Wallis test; normal human; rank sum test; software; standard; statistical analysis; stereophotogrammetry; virtual dentofacial integration; anatomy and histology; computer aided design; diagnostic imaging; face; mouth; photogrammetry; skin; smartphone; three-dimensional imaging | English | 2021 | 2021-01 | 10.3390/ijerph18010229 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Effects of Orthodontic Brackets on the Time and Accuracy of Digital Impression Taking | Background: The aim of the study was to study how the presence or the type of the orthodontic brackets influence the time measurement and accuracy of impressions using a digital oral scanner. Methods: The same models were divided into the control group (the model without a bracket), MB group (the model with a metal bracket), and CB group (the model with a monocrystalline bracket). Subsequently, scanning was conducted five times for each model using the Trios Pod 2(R). Simultaneously, the duration for taking the digital impression was measured. The degree of accuracy was compared among the three groups. Results: As compared with the control group, scanning took 53.3 s longer in the MB group and 194.23 s longer in the CB group. In the canine and the first molar, the mean values of errors were compared between the left and right sides; in both the canine and the first molar, errors between the control group and the CB group were the greatest. Conclusions: Following a comparison of the duration and accuracy of the impressions between the three groups, our results suggest that its degree was the highest in the CB group where a monocrystalline bracket was attached. | Heo, Hyojin; Kim, Minji | Kyungpook Natl Univ, Dept Prevent Dent, Sch Dent, Daegu 41940, South Korea; Ewha Womans Univ, Sch Med, Dept Orthodont, Seoul 07985, South Korea | kim, minji/GRX-9996-2022 | 57223365314; 57201330607 | hyojin7651@gmail.com;minjikim@ewha.ac.kr; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 10 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.42 | 2025-07-30 | 6 | 6 | digital impression; measuring time; orthodontic brackets; scanner accuracy | OCCLUSAL CONTACT AREAS; IN-VIVO PRECISION; INTRAORAL SCANNERS; MOLAR RELATIONSHIPS; RELIABILITY; REPRODUCIBILITY; VALIDITY; EFFICIENCY; SCANS | Digital impression; Measuring time; Orthodontic brackets; Scanner accuracy | Animals; Dental Impression Technique; Dogs; Molar; Orthodontic Brackets; accuracy assessment; dental health; measurement method; tooth; adult; Article; canine tooth; clinical article; comparative study; controlled study; digital imaging; digital impression; first molar; human; measurement accuracy; measurement error; time; animal; dental impression; dog; molar tooth; orthodontic bracket | English | 2021 | 2021-05 | 10.3390/ijerph18105282 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Feasibility of Cervical Elastography in Predicting Preterm Delivery in Singleton Pregnancy with Short Cervix Following Progesterone Treatment | Previous studies demonstrated an association between cervical strain and risk of spontaneous preterm delivery (sPTD). The present study aimed to assess the efficacy of elastography in predicting sPTD at <32 weeks of gestation in women with singleton pregnancies receiving progesterone for short cervix (<= 2.5 cm) diagnosed between 16 and 28 weeks of gestation Among 115 participants eligible for analysis, nine had sPTD at <32 weeks. Preprogesterone (PP0) mean internal os strain (IOS), elasticity contrast index (ECI), hardness ratio (HR), one-week postprogesterone (PP1) IOS, mean external os strain (EOS), ECI, and HR were significantly different between groups. Higher PP0 IOS, PP1 IOS, and PP1 EOS were associated with a 2.92, 4.39 and 3.65-fold increase in the risk of sPTD at <32 weeks, respectively (adjusted for cervical length (CL) at diagnosis; p = 0.04, 0.012 and 0.026, respectively). A combination of CL at diagnosis, PP0 IOS and PP1 EOS showed a significantly higher area under the receiver operating characteristic curve (0.858) than that of CL alone (p = 0.041). In women with singleton pregnancies receiving progesterone for short cervix, cervical elastography performed before and one week after progesterone treatment may be useful in predicting sPTD at <32 weeks of gestation. | Jung, Yun Ji; Kwon, Hayan; Shin, Jeongeun; Park, Yejin; Heo, Seok-Jae; Park, Hyun Soo; Oh, Soo-young; Sung, Ji-Hee; Seol, Hyun-Joo; Kim, Hyun Mi; Seong, Won Joon; Hwang, Han Sung; Jung, Inkyung; Kwon, Ja-Young | Yonsei Univ Hlth Syst, Yonsei Univ, Inst Womens Med Life Sci,Coll Med, Div Maternal Fetal Med,Dept Obstet & Gynecol, Seoul 03722, South Korea; Yonsei Univ, Coll Med, Dept Biomed Syst Informat, Div Biostat, Seoul 03722, South Korea; Dongguk Univ, Ilsan Hosp, Dept Obstet & Gynecol, Goyang 10326, South Korea; Sungkyunkwan Univ, Sch Med, Dept Obstet & Gynecol, Samsung Med Ctr, Seoul 06351, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Sch Med, Dept Obstet & Gynecol, Seoul 05278, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Konkuk Univ, Sch Med, Dept Obstet & Gynecol, Seoul 05030, South Korea | ; Kim, Soo/P-7880-2016; Jung, Inkyung/Q-2018-2016 | 56581000200; 36865684900; 59873739900; 57200651484; 57203964055; 57201459522; 55601514300; 56347330000; 15924081200; 57219838830; 26656946000; 17345595900; 16039030000; 8656241100 | ccstty@yuhs.ac;whitekwon@yuhs.ac;jeshin84@yuhs.ac;drsweetrain@gmail.com;sjheo@yuhs.ac;hsparkmd@gmail.com;ohsymd@skku.edu;obgysung@gmail.com;seolhj@khu.ac.kr;hyunmik@gmail.com;wjseong@knu.ac.kr;hwanghs@kuh.ac.kr;IJUNG@yuhs.ac;jaykwon@yuhs.ac; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 4 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.77 | 2025-07-30 | 13 | 12 | short cervix; elastography; progesterone; prediction; preterm delivery | Elastography; Prediction; Preterm delivery; Progesterone; Short cervix | Cervix Uteri; Elasticity Imaging Techniques; Feasibility Studies; Female; Humans; Infant, Newborn; Pregnancy; Premature Birth; Progesterone; progesterone; progesterone; feasibility study; hormone; prediction; pregnancy; public health; risk factor; adult; Article; cervical length; clinical effectiveness; cohort analysis; elastography; feasibility study; female; female genital tract parameters; gestational age; high risk pregnancy; human; image analysis; image processing; Korean (people); major clinical study; multicenter study; observational study; premature labor; prospective study; uterine cervix incompetence; diagnostic imaging; feasibility study; newborn; pregnancy; prematurity; uterine cervix | English | 2021 | 2021-02 | 10.3390/ijerph18042026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Influencing Factors of Gender Differences on Mental Burdens in Young Physiotherapists and Occupational Therapist | Background: Gender differences in personal discrimination experience, burnout, and job stress among physiotherapists and occupational therapists are considered as associated factors of job loss, poor job quality, high turnover, and economic losses due to the outflow of medical personnel. Thus, the purpose of this study is to analyze the level of burnout, personal discrimination experience, and job stress according to gender differences for young physiotherapists and occupational therapists. Furthermore, we used regression analyses to determine the contribution of gender differences in personal discrimination experience and job stress to self-reported burnout, considering gender and two age groups (younger than 30 years old vs. 30 years old and over). Methods: A total of 325 professional physiotherapists and occupational therapists were part of this study (n = 325; male n = 131; female n = 194. Age: 20-29 years old, n = 178; >= 30 years old, n = 147). Data were collected using a questionnaire including our three study variables (scales: the Maslach Burnout Inventory (MBI), a modified version of the gender section of the Medical School Graduation Questionnaire from the Association of American Medical Colleges; and the Korean version of the Job Content Questionnaire (JCQ)). Further, data on socio-demographic factors, job-related factors, health-related factors, and subjective job satisfaction were also collected. Results: There were significant positive correlations between job stress and gender differences in personal discrimination experience and job stress and burnout in women 30 years old and over. Personal experience of gender discrimination (beta = 0.179, p = 0.015) and job stress (beta = 0.162, p = 0.028) explained a significant 42.4% of the variance in burnout in the case of younger female participants (20-29 years old). However, this model did not explain a significant amount of the variance in burnout in the case of younger male participants (R-2 = 0.156, p = 0.072). Regarding participants aged 30 years and over, our results showed that only job stress (but no personal experience of gender discrimination) was a relevant predictor for both males (beta = 0.471, p < 0.001) and females (beta = 0.373, p = 0.001). Conclusion: In this study, female therapists showed higher levels of burnout than male therapists. In particular, personal discrimination experience and job stress significantly contributed to burnout in younger female therapists while job stress was the most relevant predictor variable of burnout for both males (under 30 years old and 30 years old and over) and females in their thirties and beyond. For young female physiotherapists and occupational therapists, safe working environments should be created to reduce work-related mental burdens. It is also necessary to consider policies and regulations that can prevent job stress for therapists and measures that can positively resolve the unavoidable job stress. | Lee, Su-Jin; Jung, Sang In; Kim, Myung-Gwan; Park, Eunhee; Kim, Ae-Ryoung; Kim, Chul Hyun; Hwang, Jong-Moon; Jung, Tae-Du | Kyungpook Natl Univ, Grad Sch Publ Hlth, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Unit Rehabil Therapy, Daegu 41404, South Korea; Kyungpook Natl Univ, Clin Omics Inst, Sch Med, Hakjungdong Campus, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea | 57207933350; 57022688600; 57217987383; 56107216400; 57196257330; 59603554500; 56367634000; 36622364500 | sujin89898@gmail.com;normalman80@gmail.com;curein@naver.com;ehmdpark@naver.com;ryoung20@hanmail.net;chgim@knu.ac.kr;hti82@hanmail.net;teeed0522@hanmail.net; | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | INT J ENV RES PUB HE | 1660-4601 | 18 | 6 | SCIE;SSCI | ENVIRONMENTAL SCIENCES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 4.614 | 24.5 | 0.91 | 2025-07-30 | 16 | 14 | physiotherapist; occupational therapist; burnout syndrome; gender; job stress; job satisfaction | WORK-RELATED STRESS; PHYSICAL-THERAPISTS; BURNOUT; SATISFACTION; PROFESSIONALS; UNIVERSITY; VERSION; HEAD; CARE | Burnout syndrome; Gender; Job satisfaction; Job stress; Occupational therapist; Physiotherapist | Adult; Burnout, Professional; Cross-Sectional Studies; Female; Humans; Job Satisfaction; Male; Occupational Therapists; Physical Therapists; Sex Characteristics; Surveys and Questionnaires; Young Adult; age; demography; gender discrimination; gender issue; mental health; policy approach; questionnaire survey; regulatory framework; adult; article; burnout; demography; female; groups by age; human; job satisfaction; job stress; major clinical study; male; Maslach Burnout Inventory; medical school; occupational therapist; personal experience; physiotherapist; predictor variable; questionnaire; sex difference; sexism; work environment; young adult; cross-sectional study; epidemiology; job satisfaction; occupational therapist; sexual characteristics | English | 2021 | 2021-03 | 10.3390/ijerph18062858 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of Non-Ethoxypropanoic Acid Type Cryptochrome Inhibitors with Circadian Molecular Clock-Enhancing Activity by Bioisosteric Replacement | Circadian dysfunction is closely associated with an increased risk of various diseases. Considering that molecular clock machinery serves as an intrinsic time-keeping system underlying the circadian rhythm of biological processes, the modulation of the molecular clock machinery is an attractive therapeutic target with novel mechanisms of action. Based on the previous structure-activity relationship study of small molecule cryptochrome (CRY) inhibitors possessing an ethoxypropanoic acid moiety, non-ethoxypropanoic acid-type inhibitors have been developed by bioisosteric replacement. They were evaluated as potent and effective enhancers of E-box-mediated transcription, and, in particular, ester 5d and its hydrolysis product 2d exhibited desirable metabolic and pharmacokinetic profiles as promising drug candidates. Compound 2d directly bound to both CRY1 and 2 in surface plasmon resonance analyses, suggesting that the molecular target is CRY. Effects of compound 5d and 2d on suppressive action of CRY1 on CLOCK:BMAL1-activated E-box-LUC reporter activity revealed that both compounds inhibited the negative feedback actions of CRY on CLOCK:BMAL1. Most importantly, compounds 5d and 2d exhibited significant effects on molecular circadian rhythmicity to be considered circadian clock-enhancers, distinct from the previously developed CRY inhibitors possessing an ethoxypropanoic acid moiety. | Jeong, Yong Uk; Jin, Hyo-Eon; Lim, Hye Young; Choi, Goyeong; Joo, Hansol; Kang, Bohun; Lee, Ga-Hyun; Liu, Kwang-Hyeon; Maeng, Han-Joo; Chung, Sooyoung; Son, Gi Hoon; Jung, Jong-Wha | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Vessel Organ Interact Res Ctr, Daegu 41566, South Korea; Ajou Univ, Coll Pharm, Suwon 16499, South Korea; Korea Univ, Coll Med, Dept Biomed Sci, Seoul 02841, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul 03760, South Korea | 57212274749; 55920163800; 57201758401; 57212278640; 57651840300; 57224409767; 57202873792; 55768214700; 6603632250; 7404292716; 7003374073; 26032128600 | nemo946@naver.com;hjin@ajou.ac.kr;yeppi0905@naver.com;qlgudtmfkqmf@naver.com;wnthf0518@naver.com;bohun0609@gmail.com;leegh2710@naver.com;dstlkh@knu.ac.kr;hjmaeng@gachon.ac.kr;csooy@ewha.ac.kr;songh@korea.ac.kr;jungj@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 14 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2021 | 5.215 | 24.6 | 0.43 | 2025-07-30 | 4 | 6 | circadian rhythm; circadian clock; cryptochrome inhibitor; bioisosteric replacement | IDENTIFICATION; MODULATORS | Bioisosteric replacement; Circadian clock; Circadian rhythm; Cryptochrome inhibitor | 2 (3 (1 (((4 nitrobenzyl)oxy)imino)ethyl)phenoxy)acetic acid; 2 [3 [1 [[(3 trifluoromethylbenzyl)oxy]imino]ethyl]phenoxy]acetic acid; 2 [3 [1 [[(4 methoxybenzyl)oxy]imino]ethyl]phenoxy]acetic acid; 2 [3 [1 [[(4 methylsulfonylbenzyl)oxy]imino]ethyl]phenoxy]acetic acid; 2 [3 [1 [[(4 nitrobenzyl)oxy]imino]ethyl]phenoxy]acetic acid; ethoxypropanoic acid; methyl 2 [3 [1 [[(3 trifluoromethylbenzyl)oxy]imino]ethyl]phenoxy]acetate; methyl 2 [3 [1 [[(4 methoxybenzyl)oxy]imino]ethyl]phenoxy]acetate; methyl 2 [3 [1 [[(4 methylsulfonylbenzyl)oxy]imino]ethyl]phenoxy]acetate; methyl 2 [3[1 [[(4 nitrobenzyl)oxy]imino]ethyl]phenoxy]acetate; propionic acid; protein inhibitor; transcription factor ARNTL; transcription factor CLOCK; unclassified drug; Article; circadian rhythm; controlled study; drug potency; drug structure; human; human cell; hydrolysis; negative feedback; oligomerization; process development; protein function; protein processing; protein targeting; structure activity relation; surface plasmon resonance | English | 2021 | 2021-06 | 10.3390/ph14060496 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan | Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispersion (TEL pH(M)-SD) using hot-melt extrusion (HME) technology. We prepared different TEL pH(M)-SD formulations by varying the ratio of the drug (TEL, 10-60% w/w), the hydrophilic polymer (Soluplus(R), 30-90% w/w), and pH-modifier (sodium carbonate, 0-10% w/w). More so, the tablets prepared from an optimized formulation (F8) showed a strikingly improved in vitro dissolution profile (similar to 30-fold) compared to the free drug tablets. The conversion of crystalline TEL to its amorphous state is observed through solid-state characterizations. During the stability study, F8 tablets had a better stability profile compared to the commercial product with F8, showing higher drug content, low moisture content, and negligible physical changes. Moreover, compared to the TEL powder, in vivo pharmacokinetic studies in rats showed superior pharmacokinetic parameters, with maximum serum concentration (C-max) and area under the drug concentration-time curve (AUC(0)-(infinity)) of the TEL pH(M)-SD formulation increasing by 6.61- and 5.37-fold, respectively. Collectively, the results from the current study showed that the inclusion of a hydrophilic polymer, pH modulator, and the amorphization of crystalline drugs in solid dispersion prepared by HME can be an effective strategy to improve the solubility and bioavailability of hydrophobic drugs without compromising the drug's physical stability. | Giri, Bhupendra Raj; Kwon, Jaewook; Vo, Anh Q.; Bhagurkar, Ajinkya M.; Bandari, Suresh; Kim, Dong Wuk | Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Vessel Organ Interact Res Ctr, Coll Pharm,Res Inst Pharmaceut Sci,VOICE,MRC, Daegu 41566, South Korea; Univ Mississippi, Sch Pharm, Dept Pharmaceut & Drug Delivery, University, MS 38677 USA; Hanoi Univ Pharm, Dept Phys Chem & Phys, Hanoi 100000, Vietnam | ; Giri, Bhupendra/GRR-3256-2022 | 57210211620; 57210209641; 56971019500; 56997413100; 24463204900; 57193445049 | bhupendra@knu.ac.kr;kjw11156@naver.com;anhvq@hup.edu.vn;ajinkya.bhagurkar@allergan.com;sbandari@olemiss.edu;dkim17@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 14 | 1 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2021 | 5.215 | 24.6 | 3.09 | 2025-07-30 | 40 | 41 | telmisartan; pH-modifier; solid dispersion; hot-melt extrusion (HME); solubility; bioavailability; stability | Bioavail-ability; Hot-melt extrusion (HME); PH-modifier; Solid dispersion; Solubility; Stability; Telmisartan | English | 2021 | 2021-01 | 10.3390/ph14010073 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Osteogenic and Chondrogenic Potential of Periosteum-Derived Mesenchymal Stromal Cells: Do They Hold the Key to the Future? | The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic environment with a niche of pluripotent stem cells for their reparative needs. The inner cambium layer is rich in mesenchymal progenitors, osteogenic progenitors, osteoblasts, and fibroblasts in a scant collagen matrix environment. Their role in union and remodeling of fracture is well known. However, the periosteum as a source of mesenchymal stem cells has not been explored in detail. Moreover, with the continuous expansion of techniques, newer insights have been acquired into the roles and regulation of these periosteal cells. From a therapeutic standpoint, the periosteum as a source of tissue engineering has gained much attraction. Apart from its role in bone repair, analysis of the bone-forming potential of periosteum-derived stem cells is lacking. Hence, this article elucidates the role of the periosteum as a potential source of mesenchymal stem cells along with their capacity for osteogenic and chondrogenic differentiation for therapeutic application in the future. | Jeyaraman, Madhan; Muthu, Sathish; Gangadaran, Prakash; Ranjan, Rajni; Jeyaraman, Naveen; Prajwal, Gollahalli Shivashankar; Mishra, Prabhu Chandra; Rajendran, Ramya Lakshmi; Ahn, Byeong-Cheol | Sharda Univ, Sch Med Sci & Res, Dept Orthpaed, Greater Noida 201306, Uttar Pradesh, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India; Int Assoc Stem Cell & Regenerat Med IASRM, New Delhi 110048, Uttar Pradesh, India; Govt Med Coll & Hosp, Dept Orthopaed, Dindigul 624304, Tamil Nadu, India; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program BK21,Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Atlas Hosp, Dept Orthpaed, Trichy 620002, Tamil Nadu, India; Mallika Spine Ctr, Dept Orthpaed, Guntur 522001, Andhra Pradesh, India | ; Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021; Muthu, Sathish/G-5756-2018; Jeyaraman, Madhan/ABB-8464-2020 | 57216926503; 57217850874; 54393130400; 56661828600; 57219306833; 57226062500; 57219332018; 57195318729; 7202791511 | madhanjeyaraman@gmail.com;drsathishmuthu@gmail.com;prakashg@knu.ac.kr;rajni.ranjan@sharda.ac.in;naveenjeyaraman@yahoo.com;prajwalgs1894@gmail.com;info@iasrmglobal.org;ramyag@knu.ac.kr;abc2000@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 14 | 11 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2021 | 5.215 | 24.6 | 0.46 | 2025-07-30 | 15 | 16 | periosteum; mesenchymal stromal cells; chondrogenesis; osteogenesis | STEM-CELLS; BONE-MARROW; IN-VITRO; ARTICULAR-CARTILAGE; OSTEOBLASTIC DIFFERENTIATION; EXPRESSION; PROMOTES; GROWTH; EXPANSION; RUNX2 | Chondrogenesis; Mesenchymal stromal cells; Osteogenesis; Periosteum | bone development; cell adhesion; cell differentiation; cell engineering; cell function; cell isolation; cell maturation; cell migration; cell proliferation; cell regeneration; chondrocyte; chondrogenesis; chondrogenic cell; chondrogenicity; histogenesis; human; intracellular signaling; mesenchymal stroma cell; nonhuman; ossification; osteoblast; osteogenicity; periosteum; periosteum derived mesenchymal stroma cell; Review; stem cell transplantation | English | 2021 | 2021-11 | 10.3390/ph14111133 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Prospects of Therapeutic Target and Directions for Ischemic Stroke | Stroke is a serious, adverse neurological event and the third leading cause of death and disability worldwide. Most strokes are caused by a block in cerebral blood flow, resulting in neurological deficits through the death of brain tissue. Recombinant tissue plasminogen activator (rt-PA) is currently the only immediate treatment medication for stroke. The goal of rt-PA administration is to reduce the thrombus and/or embolism via thrombolysis; however, the administration of rt-PA must occur within a very short therapeutic timeframe (3 h to 6 h) after symptom onset. Components of the pathological mechanisms involved in ischemic stroke can be used as potential biomarkers in current treatment. However, none are currently under investigation in clinical trials; thus, further studies investigating biomarkers are needed. After ischemic stroke, microglial cells can be activated and release inflammatory cytokines. These cytokines lead to severe neurotoxicity via the overactivation of microglia in prolonged and lasting insults such as stroke. Thus, the balanced regulation of microglial activation may be necessary for therapy. Stem cell therapy is a promising clinical treatment strategy for ischemic stroke. Stem cells can increase the functional recovery of damaged tissue after post-ischemic stroke through various mechanisms including the secretion of neurotrophic factors, immunomodulation, the stimulation of endogenous neurogenesis, and neovascularization. To investigate the use of stem cell therapy for neurological diseases in preclinical studies, however, it is important to develop imaging technologies that are able to evaluate disease progression and to "chase" (i.e., track or monitor) transplanted stem cells in recipients. Imaging technology development is rapidly advancing, and more sensitive techniques, such as the invasive and non-invasive multimodal techniques, are under development. Here, we summarize the potential risk factors and biomarker treatment strategies, stem cell-based therapy and emerging multimodal imaging techniques in the context of stroke. This current review provides a conceptual framework for considering the therapeutic targets and directions for the treatment of brain dysfunctions, with a particular focus on ischemic stroke. | Kim, Jung Hak; Kim, So Young; Kim, Bokyung; Lee, Sang Rae; Cha, Sang Hoon; Lee, Dong Seok; Lee, Hong Jun | E Biogen Inc, Res Inst, Seoul 07282, South Korea; Chung Ang Univ, Coll Med, Seoul 06974, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 KNU Creat BioRes Grp 4, Daegu 41566, South Korea; Ajou Univ, Lab Anim Res Ctr, Sch Med, Dept Pharmacol, Suwon 16499, South Korea; Chungbuk Natl Univ, Coll Med & Med Res Inst, Cheongju 28644, South Korea; Chungbuk Natl Univ Hosp, Dept Radiol, Cheongju 28644, South Korea | lee, wj/JNR-4926-2023 | 55671187300; 57196227409; 57205869587; 16026266200; 57200982237; 57210068061; 35215736300 | jnhkim1116@gmail.com;biochemcau@naver.com;mideun@knu.ac.kr;lsr21@ajou.ac.kr;shcha@chungbuk.ac.kr;lee1@knu.ac.kr;leehj71@gmail.com; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 14 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2021 | 5.215 | 24.6 | 1.12 | 2025-07-30 | 15 | 15 | ischemic stroke; biomarkers; microglia activation; stem cell therapy; multimodal imaging | NEURAL STEM-CELLS; TISSUE-PLASMINOGEN ACTIVATOR; AGGREGATION-INDUCED EMISSION; FIBRILLARY ACIDIC PROTEIN; VON-WILLEBRAND-FACTOR; FUNCTIONAL RECOVERY; STROMAL CELLS; RISK-FACTORS; INTRAARTERIAL TRANSPLANTATION; HEMORRHAGIC TRANSFORMATION | Biomarkers; Ischemic stroke; Microglia activation; Multimodal imaging; Stem cell therapy | alteplase; biological marker; glial fibrillary acidic protein; interleukin 10; interleukin 12; interleukin 1beta; interleukin 23; interleukin 6; neurotrophic factor; tumor necrosis factor; Article; brain ischemia; computer assisted tomography; cytokine release; fluorescence imaging; human; immunohistochemistry; immunomodulation; mesenchymal stem cell transplantation; microglia; neovascularization (pathology); nervous system inflammation; nonhuman; nuclear magnetic resonance imaging; pathogenesis; protein expression; risk assessment; risk factor; stem cell transplantation | English | 2021 | 2021-04 | 10.3390/ph14040321 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis, Characterization, and Anticancer Activity of Benzothiazole Aniline Derivatives and Their Platinum (II) Complexes as New Chemotherapy Agents | We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) complexes. We designed the compounds based on the selective antitumor properties of BTA, along with three types of metallic centers, aiming to take advantage of the distinctive and synergistic activity of the complexes to develop anticancer agents. The compounds were characterized using nuclear magnetic resonance spectrometry, Fourier transform infrared spectroscopy, mass spectrometry, elemental analysis, and tested for antiproliferative activity against multiple normal and cancerous cell lines. L1, L2, and L1Pt had better cytotoxicity in the liver, breast, lung, prostate, kidney, and brain cells than clinically used cisplatin. Especially, L1 and L1Pt demonstrated selective inhibitory activities against liver cancer cells. Therefore, these compounds can be a promising alternative to the present chemotherapy drugs. | Islam, Md. Kamrul; Baek, Ah-Rum; Sung, Bokyung; Yang, Byeong-Woo; Choi, Garam; Park, Hyun-Jin; Kim, Yeoun-Hee; Kim, Minsup; Ha, Seongmin; Lee, Gang-Ho; Kim, Hee-Kyung; Chang, Yongmin | Kyungpook Natl Univ, Inst Biomed Engn Res, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, 80 Daehak Ro, Daegu 41566, South Korea; Mirae BioPharm Co, R&D Ctr, 124 Sagimakgol Ro, Seongnam Si 13207, South Korea; InCerebro Drug Discovery Inst, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, 88 Dongnae Ro, Daegu 41061, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Islam, Md. Kamrul/AAE-3221-2021; Choi, Garam/NHP-2919-2025; Park, Hyun-Jin/HPE-8152-2023; Islam, Md Kamrul/AAE-3221-2021; Yang, Byeong Woo/HII-8624-2022 | 57193930944; 57194601711; 58929528400; 57195807615; 56013903700; 57203526784; 57576538700; 56122945800; 57239556900; 7404851841; 56014729400; 7501840633 | mkislam2008@yahoo.com;baxun@naver.com;xxgzxz4@naver.com;byungwoo1128@naver.com;garam1458@naver.com;phj0808@naver.com;bigeye38@naver.com;minsupkim.bio@gmail.com;zx996574@gmail.com;ghlee@knu.ac.kr;hkkim@dgmif.re.kr;ychang@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 14 | 8 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2021 | 5.215 | 24.6 | 1.72 | 2025-07-30 | 21 | 22 | benzothiazole aniline (BTA); platinum (II); anticancer; DNA; liver; docking | CELLS IN-VITRO; BIOLOGICAL EVALUATION; ANTITUMOR BENZOTHIAZOLES; CISPLATIN RESISTANCE; MOLECULAR DOCKING; 2-(4-AMINOPHENYL)BENZOTHIAZOLES; 2-(4'-AMINOPHENYL)BENZOTHIAZOLE; DELIVERY; PRODRUG; DESIGN | Anticancer; Benzothiazole aniline (BTA); DNA; Docking; Liver; Platinum (II) | 2 pyridin 2 yl 4,5 dihydro 1h imidazole 4 carboxylic acid (4 benzothiazol 2 ylphenyl)amide derivative; 2,3 diamino n (4 benzothiazol 2 yl phenyl) propionamide derivative; aniline derivative; antineoplastic agent; carboplatin; cisplatin; lobaplatin; n (4 benzothiazol 2 yl phenyl) 2,3 bis [(2 hydroxy benzylidene)amino] propionamide derivative; nedaplatin; oxaliplatin; unclassified drug; animal cell; antineoplastic activity; antiproliferative activity; Article; brain cancer cell line; breast cancer cell line; cancer chemotherapy; controlled study; cytotoxicity; drug screening; drug structure; drug synthesis; elemental analysis; Fourier transform infrared spectroscopy; human; human cell; human tissue; in vitro study; liver cancer cell line; lung cancer cell line; mass spectrometry; molecular model; mouse; nonhuman; nuclear magnetic resonance spectroscopy; prostate cancer cell line; renal cancer cell line; synergistic effect | English | 2021 | 2021-08 | 10.3390/ph14080832 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-glycation effects of brown algae extracts and its phenolic compounds | In this study, 50% (v/v) ethanolic extracts from 12 brown algae species were investigated for their antiglycation effects. Three glycation models, namely (bovine serum albumin with fructose [Fru-BSA], glyoxal [BSA-GO], and methylglyoxal [BSA-MGO]) were used for screening. Ecklonia cava (Ec), Leathesia difformis (Ld), and Dictyota dichotoma (Dd) exhibited the highest levels of advanced glycation end-product (AGE) inhibition in the Fru-BSA model. Ec exhibited the highest levels of advanced glycation end-product (AGE) inhibition in the BSA-MGO and BSA-GO models. Further, Ec extract exhibited the highest total antioxidant activity and phenolic content. The phenolic compounds in the extracts were identified using high-performance liquid chromatography. The AGE inhibition effects of the identified phenolic compounds (dieckol, phlorofucofuroeckol-A, gallic acid, catechin, and quercetin) were measured to evaluate the predominant AGE inhibitor among the phenolic compounds. Among the standard phenolic compounds, phlorofucofuroeckol-A and dieckol exhibited lower IC50 values in the BSA-GO and BSA-MGO models. Pearson's correlation analyses showed that dieckol, phlorofucofuroeckol-A, and quercetin in the extracts were positively correlated with BSA-MGO (r > 0.90, p 0.84, p < 0.001), whereas no significant correlation was observed between other phenolic compounds (gallic acid and catethin) and AGE inhibition effects. The findings of this study suggest that Ec extract is a suitable natural source of antiglycation agents, and that dieckol is its predominant AGE inhibitor. | Park, Jong Jin; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 41566, South Korea | Lee, Wonyoung/AAL-2780-2021; Park, Jongjin/AAL-3484-2021 | 58602432200; 57195940408 | wonyoung@knu.ac.kr; | FOOD BIOSCIENCE | FOOD BIOSCI | 2212-4292 | 2212-4306 | 41 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.318 | 24.7 | 1.03 | 2025-07-30 | 17 | 16 | Advanced glycation end products; Antioxidant; Brown algae; Phenolic compound | LACTIC-ACID FERMENTATION; ANTIOXIDANT ACTIVITY; END-PRODUCTS; PHLOROTANNINS; METHYLGLYOXAL; SEAWEEDS | Advanced glycation end products; Antioxidant; Brown algae; Phenolic compound | English | 2021 | 2021-06 | 10.1016/j.fbio.2021.101042 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of Extrusion Temperature on Mechanical Properties of AZ91 Alloy in Terms of Microstructure and Texture Development | This study investigates the effect of extrusion temperature on room temperature tensile properties of as-extruded AZ91 plates regarding microstructure and texture development. Forward extrusion was performed at 300, 350 and 400 degrees C with an extrusion ratio of 25:1. Yield strength rather increases from 212 to 224 MPa as extrusion temperature rises, despite grain growth from 11.9 to 41.2 mu m. To understand the underlying mechanisms of this unusual hardening, the effects of microstructural features are discussed with emphasis on grain size, precipitates, stored strain energy and texture. Microscopic analyses and simulation results reveal that grain refinement, continuous precipitates and stored strain have no decisive effect on yield strength. Development of stronger basal texture leads to an increase in yield strength. Texture strengthening makes basal slip more difficult to be activated when loading along the extrusion direction. Based on this, stronger basal texture plays a more dominant role in increasing yield strength. Graphic | Suh, Joung Sik; Suh, Byeong-Chan; Choi, Jae Ok; Kim, Young Min; You, Bong Sun | Korea Inst Mat Sci, Adv Met Div, Chang Won 51508, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | ; Suh, Joung/V-6760-2017; Kim, Young Min/HCH-5414-2022 | 36953311800; 56865568100; 57196004671; 58795669000; 55664007600 | jssuh@kims.re.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 27 | 8 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 3.451 | 24.7 | 1.44 | 2025-07-30 | 22 | 19 | Magnesium alloy; Extrusion; Microstructure; Texture; Mechanical properties | AL-ZN ALLOY; MAGNESIUM ALLOY; HIGH-SPEED; MG ALLOY; STRENGTH; EVOLUTION | Extrusion; Magnesium alloy; Mechanical properties; Microstructure; Texture | Extrusion; Grain growth; Grain refinement; Grain size and shape; Strain energy; Textures; Yield stress; As-extruded; Basal textures; Extrusion ratio; Extrusion temperatures; Forward extrusion; Microscopic analysis; Microstructural features; Texture development; Tensile strength | English | 2021 | 2021-08 | 10.1007/s12540-020-00642-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of Extrusion Speed on the Microstructure and Mechanical Properties of Mg-9Al-0.8Zn-0.9Ca-0.6Y-0.5MM Alloy | The effects of extrusion speed on the microstructure and tensile properties of a recently developed Mg-9Al-0.8Zn-0.9Ca-0.6Y-0.5MM (AZXWMM91100) alloy are investigated by extruding at various ram speeds of 1, 4, 7, 10, and 13 mm/s. Direct extrusion results reveal that numerous small edge cracks form in the sheets extruded at ram speeds between 4 and 10 mm/s, whereas severe hot cracking occurs during extrusion at 13 mm/s. All extruded sheets show a fully recrystallized grain structure containing second-phase particles aligned along the extrusion direction. The average size of the recrystallized grains gradually increases with the increasing ram speed, because a higher extrusion speed generates more deformation heat. However, the size, morphology, amount, and distribution of the second-phase particles are nearly identical in all the extruded sheets. As the ram speed increases from 1 to 10 mm/s, the tensile yield strength of the extruded material decreases from 205 to 125 MPa, which is attributed to the decrease in the grain-boundary hardening effect caused by the grain coarsening. The tensile elongation increases from 13.0% at 1 mm/s to 15.1% at 4 mm/s, and then greatly decreases to 2.9% at 10 mm/s. The drastic ductility degradation of the sheets extruded at the ram speeds larger than 7 mm/s is due to the formation of relatively coarse internal cracks in the material during extrusion. Graphic | Lee, Dong Hee; Kim, Sang-Hoon; Kim, Hyun Ji; Moon, Byoung Gi; Kim, Young Min; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Implementat Res Div, Chang Won 51508, South Korea | Park, Sung-Hyuk/AAE-6726-2022; Kim, Hyunjin/MDS-5282-2025; Kim, Sang-Hoon/AAD-8797-2021; Kim, Young Min/HCH-5414-2022 | 57218922670; 57206878833; 59866513600; 7101878674; 58795669000; 54786002500 | sh.park@knu.ac.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 27 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 3.451 | 24.7 | 2 | 2025-07-30 | 28 | 26 | Magnesium; Extrusion; Microstructure; Strength; Elongation | YIELD ASYMMETRY; ZN ALLOY; STRENGTH; TEMPERATURE; MAGNESIUM | Elongation; Extrusion; Magnesium; Microstructure; Strength | Coarsening; Cracks; Extrusion; Grain boundaries; Morphology; Recrystallization (metallurgy); Speed; Direct extrusion; Extruded materials; Grain boundary hardening; Microstructure and mechanical properties; Recrystallized grains; Second phase particles; Tensile elongation; Tensile yield strength; Tensile strength | English | 2021 | 2021-03 | 10.1007/s12540-020-00867-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evolution of Microstructure and Mechanical Properties of Graphitized Fe-0.55C-2.3Si Steel During Quenching and Tempering Treatment | This study investigates the variations in the microstructure and mechanical properties of a medium-carbon high-Si steel (Fe-0.55C-2.3Si) during graphitization heat treatment and subsequent quenching and tempering heat treatment. The microstructure comprising ferrite and pearlite of the as-rolled sample changes to a more ductile microstructure with fine graphites uniformly dispersed in the ferrite matrix after graphitization treatment. These formed graphites are completely dissolved into the ferrite matrix after austenitizing treatment at 900 degrees C, but preexisting graphite positions remains as voids. The average size and number density of voids are nearly identical to those of the pre-existed graphites. The subsequent tempering treatments at 300 degrees C and 500 degrees C cause little changes in the size and number of the voids. Therefore, the formation of voids in the quenched-and-tempered samples is directly related to the graphites of the initial graphitized sample. The average size of graphites and voids is inversely proportional to the logarithm of their number density. When the as-rolled sample is completely graphitized, its ultimate tensile strength decreases from 928 to 494 MPa and its tensile elongation increases from 20.7 to 34.0%, indicating that the medium-carbon high-Si steel is substantially softened through graphitization treatment. Moreover, subsequent quenching and tempering treatment at 500 degrees C increases its ultimate tensile strength to 1168 MPa. The drastic softening through graphitization and significant strengthening through subsequent quenching and tempering exhibit the possibility of the application of medium-carbon, high-Si steels as cold heading quality steels for manufacturing fastener components. | Kim, Ye Jin; Bae, Sang Woo; Lim, Nam Suk; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; POSCO, POSCO Tech Res Labs, Pohang 37859, South Korea | Park, Sung-Hyuk/AAE-6726-2022 | 59052467200; 57192585983; 50161768100; 54786002500 | sh.park@knu.ac.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 27 | 10 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 3.451 | 24.7 | 0.32 | 2025-07-30 | 6 | 5 | High-silicon steel; Microstructure; Graphite; Void; Mechanical properties | PARTICLES; AUSTENITE; KINETICS; VANADIUM | Graphite; High-silicon steel; Mechanical properties; Microstructure; Void | Cold heading; Ferrite; Graphitization; Matrix algebra; Microstructural evolution; Quenching; Silicon steel; Tempering; Tensile strength; Ferrite matrix; High Si steel; Microstructure and mechanical properties; Number density; Quenching and tempering; Tempering treatments; Tensile elongation; Ultimate tensile strength; Graphite | English | 2021 | 2021-10 | 10.1007/s12540-020-00743-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification and improvement of volatile profiles of Allomyrina dichotoma larvae by fermentation with lactic acid bacteria | The larva of Allomyrina dichotoma is an edible insect that is widely consumed in Asia. A. dichotoma larvae are reported to be beneficial to human health. They have a high nutritional value, so consumer demand is increasing. However, A. dichotoma larvae have a unique off-flavor that adversely affects consumer preference. In this study, HS-SPME/GC-MS was used to identify the unique volatile profiles and potential off-flavor volatiles in A. dichotoma larvae. Also, fermentation process of A. dichotoma larvae with various lactic acid bacteria was applied to improve their safety and overall flavor. As a result, a total of 36 volatiles were identified from A. dichotoma larvae. Lactic acid fermentation showed a decrease in indole, pyrazines, 1-octen-3-ol, and 3-octanol and an increase of propanol, ethanol, and acetone. These changes in volatiles may improve overall flavor of the larvae by reducing a fecal, roasted, earthy, mushroom, and animal odors and by enhancing sweet or bitter flavors. The volatile profiles of A. dichotoma larvae provide useful information for further studies focusing on reducing their off-flavor. | Lee, Ha Eun; Kim, Jungyeon; Kim, Yeojin; Bang, Won Yeong; Yang, Jungwoo; Lee, Sung-Joon; Jung, Young Hoon | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul 02841, South Korea; Ildong Biosci, 17 Poseunggongdan Ro, Pyeongtaek Si 17957, Gyeonggi Do, South Korea | Jung, Young Hoon/F-1703-2013; Jung, Young/F-1703-2013; Lee, Ha-Eun/HWQ-6568-2023; Kim, Jinkwon/AAR-6729-2021 | 58601955500; 57214338692; 56045514100; 57208701768; 56076383700; 23065729100; 55550063700 | younghoonjung@knu.ac.kr; | FOOD BIOSCIENCE | FOOD BIOSCI | 2212-4292 | 2212-4306 | 43 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 5.318 | 24.7 | 0.52 | 2025-07-30 | 8 | 9 | Allomyrina dichotoma; Off-flavor control; Edible insects; Fermentation; Lactic acid bacteria | NUTRITIONAL COMPOSITION; FLAVOR COMPOUNDS; EDIBLE INSECTS; INHIBITION; SAFETY; FOODS | Allomyrina dichotoma; Edible insects; Fermentation; Lactic acid bacteria; Off-flavor control | English | 2021 | 2021-10 | 10.1016/j.fbio.2021.101257 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Significant Improvement in Extrudability of Mg-9Al-0.8Zn-0.9Ca-0.6Y Alloy Through Mischmetal Addition | The combined addition of small amounts of Ca and Y to Mg-Al-Zn alloys has recently been found to greatly improve the ignition resistance, corrosion resistance, and mechanical properties of these alloys. However, Mg-Al-Zn-Ca-Y alloys with high Al content show poor extrudability, which is an obstacle to their use as extruded components in industrial applications. This study aims to improve the extrudability of a Mg-Al-Zn-Ca-Y alloy through the addition of a small amount of mischmetal (MM). To this end, a trace amount (0.5 wt%) of Ce-rich MM is added to a Mg-9Al-0.8Zn-0.9Ca-0.6Y (AZXW9110) alloy. MM addition leads to significant grain refinement of the homogenized billet, from 326 to 180 mu m. When the MM-added alloy is extruded into a sheet at 350 degrees C with an extrusion ratio of 22.9, the maximum ram speed at which it is extrudable without the occurrence of hot cracking is 12 mm/s, substantially higher than the 2 mm/s possible without MM addition. The Ce and La atoms decomposed from the MM are dissolved in the Mg17Al12, Al8Mn4Y, Al2Ca, and Al2Y phases, apparently leading to an increase in the thermal stability of the phases and, consequently, to an improvement in the AZXW9110 alloy's extrudability. At ram speeds above 2 mm/s, many small-sized cracks form at the edges of the extruded AZXW9110-0.5MM sheets. As the ram speed increases up to 6 mm/s, the number density of edge cracks gradually increases while their average spacing decreases, but beyond 6 mm/s both remain almost unchanged. | Kim, Hyun Ji; Kim, Sang-Hoon; Lee, Sang Won; Moon, Byoung Gi; Kim, Young Min; Lee, Jeong Hun; Yoon, Jonghun; Yu, Hui; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Daejeon 34141, South Korea; Korea Inst Mat Sci, Implementat Res Div, Chang Won 51508, South Korea; Korea Inst Ind Technol, Ulsan Reg Div, Ulsan 44413, South Korea; Hanyang Univ, Dept Mech Engn, Ansan 15588, South Korea; Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China | yu, hui/H-8481-2012; Lee, Sangwon/AAJ-7850-2020; Kim, Young Min/HCH-5414-2022; Yu, Hui/H-8481-2012; Park, Sung-Hyuk/AAE-6726-2022; Kim, Sang-Hoon/AAD-8797-2021; Lee, Jeong Hun/KFS-8195-2024; Kim, Hyunjin/MDS-5282-2025 | 59866513600; 57206878833; 57201375104; 7101878674; 58795669000; 54785958500; 56449838900; 7405855938; 54786002500 | sh.park@knu.ac.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 27 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2021 | 3.451 | 24.7 | 1.76 | 2025-07-30 | 28 | 27 | Magnesium; Mischmetal; Extrusion; Hot cracking; Microstructure | MECHANICAL-PROPERTIES; HIGH-SPEED; GRAIN-SIZE; MICROSTRUCTURE; EXTRUSION; STRENGTH; CA; MAGNESIUM | Extrusion; Hot cracking; Magnesium; Microstructure; Mischmetal | Aluminum corrosion; Binary alloys; Calcium alloys; Corrosion resistance; Corrosion resistant alloys; Cracks; Grain refinement; Magnesium alloys; Manganese alloys; Rare earth alloys; Thermodynamic stability; Zinc alloys; Average spacing; Extrudability; Extrusion ratio; High Al content; Hot cracking; Ignition resistances; Number density; Trace amounts; Aluminum alloys | English | 2021 | 2021-03 | 10.1007/s12540-020-00822-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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